Phase II trial of the mTOR inhibitor, temsirolimus and evaluation of circulating tumor cells and tumor biomarkers in persistent and recurrent epithelial ovarian and primary peritoneal malignancies: a Gynecologic Oncology Group study.

scientific article published on 12 July 2011

Phase II trial of the mTOR inhibitor, temsirolimus and evaluation of circulating tumor cells and tumor biomarkers in persistent and recurrent epithelial ovarian and primary peritoneal malignancies: a Gynecologic Oncology Group study. is …
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scholarly articleQ13442814

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P356DOI10.1016/J.YGYNO.2011.06.022
P932PMC publication ID3336961
P698PubMed publication ID21752435
P5875ResearchGate publication ID51488802

P50authorKian BehbakhtQ56332429
R Katherine AlpaughQ88903151
P2093author name stringAndrew K Godwin
Michael W Sill
Robert S Mannel
Kathleen M Darcy
Russell J Schilder
Kathy Q Cai
Stephen C Rubin
Steven Waggoner
P2860cites workActive-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2Q21145847
Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapyQ21198871
Quantitation of circulating tumor cells in blood samples from ovarian and prostate cancer patients using tumor-specific fluorescent ligandsQ24655544
Nonparametric Estimation from Incomplete ObservationsQ25938997
Cancer statistics, 2008Q27860585
TOR, a central controller of cell growthQ27933354
Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group StudyQ28258045
Upstream and downstream of mTORQ28277365
Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseasesQ28289395
Ras, PI(3)K and mTOR signalling controls tumour cell growthQ29614734
Detection of mutations in EGFR in circulating lung-cancer cellsQ29615033
Circulating tumor cells, disease progression, and survival in metastatic breast cancerQ29619276
Detection of circulating tumor cells from renal carcinoma patients: experiences of a two-center study.Q30320163
Activity of sorafenib in recurrent ovarian cancer and primary peritoneal carcinomatosis: a gynecologic oncology group trialQ30429122
Isolation and characterization of circulating tumor cells in patients with metastatic colorectal cancerQ33255975
Lack of efficacy of 24-h infusional topotecan in platinum-refractory ovarian cancer: A Gynecologic Oncology Group trialQ33330937
Phase II evaluation of 24-h continuous infusion topotecan in recurrent, potentially platinum-sensitive ovarian cancer: A Gynecologic Oncology Group studyQ33331940
Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancerQ33360724
In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft modelQ33362103
Treatment Options in Metastatic Renal Cell Carcinoma: Focus on mTOR InhibitorsQ33985467
Altretamine (hexamethylmelamine) in platinum-resistant and platinum-refractory ovarian cancer: a Gynecologic Oncology Group phase II trialQ34748619
Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancerQ34790678
A Gynecologic Oncology Group phase II trial of the protein kinase C-beta inhibitor, enzastaurin and evaluation of markers with potential predictive and prognostic value in persistent or recurrent epithelial ovarian and primary peritoneal malignancieQ35000494
Clinical development of mammalian target of rapamycin inhibitorsQ35038759
A phase II trial of CI-958 in recurrent platinum-sensitive ovarian carcinoma: a Gynecologic Oncology Group study.Q54008322
A Network Algorithm for Performing Fisher's Exact Test in r × c Contingency TablesQ56432190
Association of disease progression and poor overall survival with detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancerQ57756474
Circulating Tumor Cell Analysis in Patients with Progressive Castration-Resistant Prostate CancerQ63965940
Circulating Tumor Cell Number and Prognosis in Progressive Castration-Resistant Prostate CancerQ63965942
Phase II trial of CI-958 in recurrent platinum-refractory ovarian carcinoma. A Gynecologic Oncology Group StudyQ73265209
Tomudex (ZD1694, NSC 639186) in platinum-pretreated recurrent epithelial ovarian cancer: a phase II study by the Gynecologic Oncology GroupQ74628247
Monitoring expression of HER-2 on circulating epithelial cells in patients with advanced breast cancerQ78347889
Evaluation of monoclonal humanized anti-HER2 antibody, trastuzumab, in patients with recurrent or refractory ovarian or primary peritoneal carcinoma with overexpression of HER2: a phase II trial of the Gynecologic Oncology GroupQ78785334
Comparison of two methods for enumerating circulating tumor cells in carcinoma patientsQ81162598
Circulating tumor cells in metastatic breast cancer: from prognostic stratification to modification of the staging system?Q81952877
Antiangiogenic drugs in ovarian cancerQ84386233
AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cellsQ35747042
In vivo quantitation of rare circulating tumor cells by multiphoton intravital flow cytometryQ35880206
Epithelial ovarian cancer: a review of current managementQ36252039
Mammalian target of rapamycin as a therapeutic target in leukemiaQ36321019
Systemic therapy for ovarian cancer: current status and new treatmentsQ36485315
Integrating circulating tumor cell assays into the management of breast cancerQ36883679
Clinical evaluation of M30 and M65 ELISA cell death assays as circulating biomarkers in a drug-sensitive tumor, testicular cancerQ36897795
Molecular markers detecting circulating melanoma cells by reverse transcription polymerase chain reaction: methodological pitfalls and clinical relevanceQ37340909
mTOR is a promising therapeutic target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovaryQ37346570
Detection of circulating tumor cells in bladder cancer patientsQ37356665
Current status on biologic therapies in the treatment of epithelial ovarian cancerQ37453118
Targeting mTOR globally in cancer: thinking beyond rapamycinQ37630203
Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growthQ37645017
Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motilityQ39804812
Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycinQ39827828
Regulation of D-cyclin translation inhibition in myeloma cells treated with mammalian target of rapamycin inhibitors: rationale for combined treatment with extracellular signal-regulated kinase inhibitors and rapamycin.Q39896259
RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer modelQ40106656
Phase II study of oxaliplatin in platinum-resistant and refractory ovarian cancer: a gynecologic group studyQ40571931
AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growthQ42463490
Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiationQ42504535
mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancerQ42660087
A phase II evaluation of bortezomib in the treatment of recurrent platinum-sensitive ovarian or primary peritoneal cancer: a Gynecologic Oncology Group studyQ43284690
Phase II trial of pyrazoloacridine in recurrent platinum-resistant ovarian cancer: a Gynecologic Oncology Group studyQ44528127
Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinomaQ44551425
Circulating tumor cells in patients with castration-resistant prostate cancer baseline values and correlation with prognostic factors.Q45977867
Prognostic significance of circulating tumor cells in patients with metastatic colorectal cancerQ46090380
Phase II evaluation of imatinib mesylate in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group StudyQ46494607
Phase II study of gefitinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: a Gynecologic Oncology Group StudyQ46630310
Evaluation of cisplatin and cyclosporin A in recurrent platinum-resistant ovarian cancer: a phase II study of the gynecologic oncology groupQ46756927
Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancerQ46892024
Frequent activation of AKT2 kinase in human pancreatic carcinomasQ47251291
The Proof and Measurement of Association between Two ThingsQ50368932
The treatment of ties in ranking problemsQ53055431
Phase II study of paclitaxel and valspodar (PSC 833) in refractory ovarian carcinoma: a gynecologic oncology group study.Q53324757
A phase II trial of dolastatin-10 in recurrent platinum-sensitive ovarian carcinoma: a Gynecologic Oncology Group study.Q53656621
[Rapamycin and CCI-779]Q53805382
A phase I and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancer.Q53984577
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectgynecologic oncologyQ5625186
biomarkerQ864574
phase II clinical trialQ42824440
P304page(s)19-26
P577publication date2011-07-12
P1433published inGynecologic OncologyQ5625182
P1476titlePhase II trial of the mTOR inhibitor, temsirolimus and evaluation of circulating tumor cells and tumor biomarkers in persistent and recurrent epithelial ovarian and primary peritoneal malignancies: a Gynecologic Oncology Group study
P478volume123