A Dual-Modality Herpes Simplex Virus 2 Vaccine for Preventing Genital Herpes by Using Glycoprotein C and D Subunit Antigens To Induce Potent Antibody Responses and Adenovirus Vectors Containing Capsid and Tegument Proteins as T Cell Immunogens

scientific article published on 3 June 2015

A Dual-Modality Herpes Simplex Virus 2 Vaccine for Preventing Genital Herpes by Using Glycoprotein C and D Subunit Antigens To Induce Potent Antibody Responses and Adenovirus Vectors Containing Capsid and Tegument Proteins as T Cell Immunogens is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.01089-15
P932PMC publication ID4524253
P698PubMed publication ID26041292

P50authorLawrence CoreyQ6503944
Meei-Li HuangQ61713476
Harvey M. FriedmanQ89912954
David M KoelleQ40734874
P2093author name stringSita Awasthi
Gregory G Mahairas
Christine Posavad
Carolyn E Shaw
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Herpes simplex virus type 1 and 2 glycoprotein C prevents complement-mediated neutralization induced by natural immunoglobulin M antibody.Q34545821
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Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infectionQ35129667
Immunization with a vaccine combining herpes simplex virus 2 (HSV-2) glycoprotein C (gC) and gD subunits improves the protection of dorsal root ganglia in mice and reduces the frequency of recurrent vaginal shedding of HSV-2 DNA in guinea pigs compaQ35275146
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Glycoprotein C of herpes simplex virus 1 is an inhibitor of the complement cascadeQ41367489
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P433issue16
P407language of work or nameEnglishQ1860
P921main subjectAdenoviridaeQ193447
vector-borne diseaseQ2083837
genital herpesQ7476596
sexual transmissionQ45349134
P304page(s)8497-8509
P577publication date2015-06-03
P1433published inJournal of VirologyQ1251128
P1476titleA Dual-Modality Herpes Simplex Virus 2 Vaccine for Preventing Genital Herpes by Using Glycoprotein C and D Subunit Antigens To Induce Potent Antibody Responses and Adenovirus Vectors Containing Capsid and Tegument Proteins as T Cell Immunogens
P478volume89

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cites work (P2860)
Q57072187A new era in cytomegalovirus vaccinology: considerations for rational design of next-generation vaccines to prevent congenital cytomegalovirus infection
Q34501866A novel HSV-2 subunit vaccine induces GLA-dependent CD4 and CD8 T cell responses and protective immunity in mice and guinea pigs.
Q40210971A trivalent subunit antigen glycoprotein vaccine as immunotherapy for genital herpes in the guinea pig genital infection model
Q64114856Duration of protection from live attenuated vs. sub unit HSV-2 vaccines in the guinea pig model of genital herpes: Reassessing efficacy using endpoints from clinical trials
Q30235026Genital Herpes: Insights into Sexually Transmitted Infectious Disease

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