Comprehensive review of the detection methods for synthetic cannabinoids and cathinones

scientific article published on 6 March 2015

Comprehensive review of the detection methods for synthetic cannabinoids and cathinones is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S11419-015-0270-0
P932PMC publication ID4525208
P698PubMed publication ID26257831
P5875ResearchGate publication ID276605048

P2093author name stringTakeshi Saito
Akihiro Nakamoto
Akira Namera
Maho Kawamura
Masataka Nagao
P2860cites workMetabolism of the new designer drug α-pyrrolidinopropiophenone (PPP) and the toxicological detection of PPP and 4′-methyl-α-pyrrolidinopropiophenone (MPPP) studied in rat urine using gas chromatography-mass spectrometryQ28212734
Analysis of NRG 'legal highs' in the UK: identification and formation of novel cathinonesQ28249380
Toxicological determination and in vitro metabolism of the designer drug methylenedioxypyrovalerone (MDPV) by gas chromatography/mass spectrometry and liquid chromatography/quadrupole time-of-flight mass spectrometryQ28292326
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Identification and characterization of the new designer drug 4'-methylethcathinone (4-MEC) and elaboration of a novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) screening method for seven different methcathinone analogsQ33874959
Validation of the only commercially available immunoassay for synthetic cathinones in urine: Randox Drugs of Abuse V Biochip Array TechnologyQ33934379
3,4-Methylenedioxypyrovalerone (MDPV) and metabolites quantification in human and rat plasma by liquid chromatography-high resolution mass spectrometryQ34115248
Analyses of second-generation 'legal highs' in the UK: initial findings.Q34129831
Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urineQ34179558
Clinical experience with and analytical confirmation of "bath salts" and "legal highs" (synthetic cathinones) in the United StatesQ34206558
Prevalence of new psychoactive substances: A retrospective study in hairQ34270004
Synthetic cannabinoids in "spice-like" herbal blends: first appearance of JWH-307 and recurrence of JWH-018 on the German marketQ34285144
Analysis of 30 synthetic cannabinoids in serum by liquid chromatography-electrospray ionization tandem mass spectrometry after liquid-liquid extractionQ34287774
Ring positional differentiation of isomeric N-alkylated fluorocathinones by gas chromatography/tandem mass spectrometryQ34297033
Analysis of synthetic cathinones commonly found in bath salts in human performance and postmortem toxicology: method development, drug distribution and interpretation of resultsQ34325173
Four postmortem case reports with quantitative detection of the synthetic cannabinoid, 5F-PB-22Q34421975
3-Naphthoylindazoles and 2-naphthoylbenzoimidazoles as novel chemical groups of synthetic cannabinoids: chemical structure elucidation, analytical characteristics and identification of the first representatives in smoke mixturesQ34429666
Qualitative confirmation of 9 synthetic cannabinoids and 20 metabolites in human urine using LC-MS/MS and library searchQ34607414
New designer drug alpha-pyrrolidinovalerophenone (PVP): studies on its metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniquesQ34951585
K2 toxicity: fatal case of psychiatric complications following AM2201 exposureQ35057032
Solid-phase extraction and quantitative measurement of omega and omega-1 metabolites of JWH-018 and JWH-073 in human urineQ35164115
Death following recreational use of designer drug "bath salts" containing 3,4-Methylenedioxypyrovalerone (MDPV).Q36548946
Use of SPME-HS-GC-MS for the analysis of herbal products containing synthetic cannabinoids.Q36727502
Simultaneous quantification of 20 synthetic cannabinoids and 21 metabolites, and semi-quantification of 12 alkyl hydroxy metabolites in human urine by liquid chromatography-tandem mass spectrometryQ37658304
Mephedrone (4-methylmethcathinone): what is new in our understanding of its use and toxicityQ38008088
New challenges and innovation in forensic toxicology: focus on the "New Psychoactive Substances".Q38075223
Methylenedioxypyrovalerone ("bath salts"), related death: case report and review of the literatureQ38119006
Synthetic cannabinoids: analysis and metabolites.Q38177548
Analysis of Synthetic Cannabinoids in Botanical Material: A Review of Analytical Methods and Findings.Q38557647
Psychoactive substances--some new, some old: a scan of the situation in the U.S.Q39329780
Identification of substituted cathinones: 3,4-Methylenedioxy derivatives by high performance liquid chromatography-quadrupole time of flight mass spectrometryQ39432357
Three fatal intoxications due to methyloneQ40286882
New designer drug of abuse: 3,4-Methylenedioxypyrovalerone (MDPV). Findings from apprehended drivers in FinlandQ42743410
Mephedrone (4-methylmethcathinone)-related deathsQ42744621
A case of extreme agitation and death after the use of mephedrone in The NetherlandsQ42758489
The detection of mephedrone (4-methylmethcathinone) in 4 fatalities in ScotlandQ42946688
Sensitive and rapid quantification of the cannabinoid receptor agonist naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) in human serum by liquid chromatography-tandem mass spectrometryQ43105766
Validation of a novel immunoassay for the detection of synthetic cannabinoids and metabolites in urine specimensQ43575688
Distribution of methylone in four postmortem casesQ43666311
Analysis of 30 synthetic cannabinoids in oral fluid using liquid chromatography-electrospray ionization tandem mass spectrometryQ43891404
Analysis of MDPV in blood--determination and interpretationQ44006688
Urine analysis of 3,4-methylenedioxypyrovalerone in opioid-dependent patients by gas chromatography-mass spectrometryQ44349023
Fragmentation pathways of drugs of abuse and their metabolites based on QTOF MS/MS and MS(E) accurate-mass spectra.Q44453727
Presence and composition of cathinone derivatives in drug samples taken from a drug test service in Spain (2010-2012).Q44665582
Fatal mephedrone intoxication--a case reportQ45067994
Gas and liquid chromatography-mass spectrometry detection of the urinary metabolites of UR-144 and its major pyrolysis product.Q45105082
Deaths involving methylenedioxypyrovalerone (MDPV) in Upper East TennesseeQ45120474
Simultaneous quantification of 28 synthetic cathinones and metabolites in urine by liquid chromatography-high resolution mass spectrometryQ45219952
The stability of four designer drugs: MDPV, mephedrone, BZP and TFMPP in three biological matrices under various storage conditionsQ45764870
Analysis of UR-144 and its pyrolysis product in blood and their metabolites in urine.Q45962466
Postmortem tissue distribution of MDPV following lethal intoxication by "bath salts".Q46004696
Cross-reactivity of designer drugs, including cathinone derivatives, in commercial enzyme-linked immunosorbent assaysQ46187150
Determination of 32 cathinone derivatives and other designer drugs in serum by comprehensive LC-QQQ-MS/MS analysisQ46456473
The emergence and analysis of synthetic cannabinoidsQ47794557
A mixed MDPV and benzodiazepine intoxication in a chronic drug abuser: determination of MDPV metabolites by LC-HRMS and discussion of the caseQ47817715
"Legal highs"--toxicity in the clinical and medico-legal aspect as exemplified by suicide with bk-MBDB administrationQ48670180
Analysis of 4-MEC in biological and non-biological material--three case reportsQ50056262
Detection of buphedrone in biological and non-biological material--two case reportsQ50058343
Forensic investigation of K2, Spice, and "bath salt" commercial preparations: a three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds.Q50467281
Driving under the influence of synthetic cannabinoids ("Spice"): a case series.Q51026124
Quadrupole-time-of-flight mass spectrometry screening for synthetic cannabinoids in herbal blends.Q51808092
Acute toxicity due to the confirmed consumption of synthetic cannabinoids: clinical and laboratory findings.Q52301471
Simultaneous analysis of synthetic cannabinoids in the materials seized during drug trafficking using GC-MS.Q53351420
'Spice' and other herbal blends: harmless incense or cannabinoid designer drugs?Q55051416
Patterns of synthetic cannabinoid use in Australia.Q55056749
Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonistQ55877584
Identification of two new-type synthetic cannabinoids, N-(1-adamantyl)-1-pentyl-1H-indole-3-carboxamide (APICA) and N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide (APINACA), and detection of five synthetic cannabinoids, AM-1220, AM-2233, AM-1241,Q56460366
New cannabimimetic indazole derivatives, N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide (AB-PINACA) and N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide (AB-FUBINACA) identified as designer drQ56523074
The characterization of some 3,4-methylenedioxycathinone (MDCATH) homologsQ56553418
Structural characterization of cathinone-type designer drugs by EI mass spectrometryQ56607872
Chemical analysis of a benzofuran derivative, 2-(2-ethylaminopropyl)benzofuran (2-EAPB), eight synthetic cannabinoids, five cathinone derivatives, and five other designer drugs newly detected in illegal productsQ56609546
Determination of cathinones and related ephedrines in forensic whole-blood samples by liquid-chromatography–electrospray tandem mass spectrometryQ56767430
Intoxication Delirium following Use of Synthetic Cathinone DerivativesQ58161758
Identification and structural characterization of the synthetic cannabinoid 3-(1-adamantoyl)-1-pentylindole as an additive in ‘herbal incense’Q59179000
Identification of the major urinary metabolites in man of seven synthetic cannabinoids of the aminoalkylindole type present as adulterants in ‘herbal mixtures’ using LC-MS/MS techniquesQ59179004
Development and validation of a liquid chromatography-tandem mass spectrometry method for the quantitation of synthetic cannabinoids of the aminoalkylindole type and methanandamide in serum and its application to forensic samplesQ59179011
In silico and in vitro metabolism studies support identification of designer drugs in human urine by liquid chromatography/quadrupole-time-of-flight mass spectrometryQ61037219
[A new designer drug: methylone related death]Q83409357
Detection of JWH-018 and JWH-073 by UPLC-MS-MS in postmortem whole blood caseworkQ83646003
LC-MS/MS method for the quantitation of metabolites of eight commonly-used synthetic cannabinoids in human urine--an Australian perspectiveQ83947389
Identification of naphthoylindoles acting on cannabinoid receptors based on their fragmentation patterns under ESI-QTOFMSQ84108905
Identification of synthetic cannabinoids in herbal incense blends in the United StatesQ84627915
Determination of 22 synthetic cannabinoids in human hair by liquid chromatography-tandem mass spectrometryQ84629641
Development and validation of a liquid chromatography-tandem mass spectrometry method for the identification and quantification of JWH-018, JWH-073, JWH-019, and JWH-250 in human whole bloodQ84837090
High-throughput bioanalytical method for analysis of synthetic cannabinoid metabolites in urine using salting-out sample preparation and LC-MS/MSQ85444589
Mephedrone (methylmethcathinone) in toxicology casework: a Northern Ireland perspectiveQ85963858
LC/ESI-MS/MS method for quantification of 28 synthetic cannabinoids in neat oral fluid and its application to preliminary studies on their detection windowsQ86499164
Acute intoxication by synthetic cannabinoids--four case reportsQ86838249
Blood synthetic cannabinoid concentrations in cases of suspected impaired drivingQ87290337
A liquid chromatography-mass spectrometry method based on class characteristic fragmentation pathways to detect the class of indole-derivative synthetic cannabinoids in biological samplesQ87360852
Analytical differentiation of 1-alkyl-3-acylindoles and 1-acyl-3-alkylindoles: isomeric synthetic cannabinoidsQ87417464
A structure-reactivity relationship driven approach to the identification of a color test protocol for the presumptive indication of synthetic cannabimimetic drugs of abuseQ87445511
Testing for designer stimulants: metabolic profiles of 16 synthetic cathinones excreted free in human urineQ87518537
Quantitative analysis of 3,4-dimethylmethcathinone in blood and urine by liquid chromatography-tandem mass spectrometry in a fatal caseQ87780354
Postmortem distribution of α-pyrrolidinobutiophenone in body fluids and solid tissues of a human cadaverQ88007735
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectcannabinoidsQ422936
AM-694Q4652501
P304page(s)175-194
P577publication date2015-03-06
P1433published inForensic ToxicologyQ15724497
P1476titleComprehensive review of the detection methods for synthetic cannabinoids and cathinones
P478volume33

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