Comprehensive Screening for Naturally Occurring Hepatitis C Virus Resistance to Direct-Acting Antivirals in the NS3, NS5A, and NS5B Genes in Worldwide Isolates of Viral Genotypes 1 to 6

scientific article published on 8 February 2016

Comprehensive Screening for Naturally Occurring Hepatitis C Virus Resistance to Direct-Acting Antivirals in the NS3, NS5A, and NS5B Genes in Worldwide Isolates of Viral Genotypes 1 to 6 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.02776-15
P932PMC publication ID4808155
P698PubMed publication ID26856832

P50authorKarina SalvatierraQ61013710
Juan Ángel Patiño-GalindoQ61130863
F X López-LabradorQ71257032
Fernando González-CandelasQ28322701
P2093author name stringFernando González-Candelas
Juan Ángel Patiño-Galindo
Karina Salvatierra
P2860cites workPeginterferon alfa-2b and ribavirin for 12 vs. 24 weeks in HCV genotype 2 or 3.Q42993387
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The Evolution of the Major Hepatitis C Genotypes Correlates with Clinical Response to Interferon TherapyQ27489040
New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0Q27860476
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HCV genotypes are differently prone to the development of resistance to linear and macrocyclic protease inhibitorsQ28481038
Similar prevalence of low-abundance drug-resistant variants in treatment-naive patients with genotype 1a and 1b hepatitis C virus infections as determined by ultradeep pyrosequencingQ28542443
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Naturally occurring resistance mutations to inhibitors of HCV NS5A region and NS5B polymerase in DAA treatment-naïve patientsQ37426527
Resistance to direct antiviral agents in patients with hepatitis C virus infectionQ37652739
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Epidemiology and natural history of HCV infection.Q38118578
Importance of HCV genotype 1 subtypes for drug resistance and response to therapyQ38193551
Hepatitis C virus genetic variability and the presence of NS5B resistance-associated mutations as natural polymorphisms in selected genotypes could affect the response to NS5B inhibitorsQ38849307
Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an NS5A inhibitor but not interferon-α.Q39626790
Sensitivity of NS3 serine proteases from hepatitis C virus genotypes 2 and 3 to the inhibitor BILN 2061.Q40967696
Identification of the NS5B S282T resistant variant and two novel amino acid substitutions that affect replication capacity in hepatitis C virus-infected patients treated with mericitabine and danoprevirQ41076434
Global origin and transmission of hepatitis C virus nonstructural protein 3 Q80K polymorphismQ41666553
Protease inhibitor resistance mutations in untreated Brazilian patients infected with HCV: novel insights about targeted genotyping approachesQ42205040
Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: variability and stabilityQ42599975
Signature pattern analysis: a method for assessing viral sequence relatednessQ42605822
Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3.4A protease inhibitors in treatment-naive subjectsQ42980129
Mapping natural polymorphisms of hepatitis C virus NS3/4A protease and antiviral resistance to inhibitors in worldwide isolatesQ42980467
The Los Alamos hepatitis C sequence databaseQ42987686
Resistance analysis of hepatitis C virus genotype 1 prior treatment null responders receiving daclatasvir and asunaprevirQ42990234
Naturally occurring substitutions conferring resistance to hepatitis C virus polymerase inhibitors in treatment-naive patients infected with genotypes 1-5.Q42990352
The presence of resistance mutations to protease and polymerase inhibitors in Hepatitis C virus sequences from the Los Alamos databankQ42991856
P433issue4
P407language of work or nameEnglishQ1860
P921main subjecthepatitis CQ154869
Hepatitis C virusQ708693
P304page(s)2402-2416
P577publication date2016-02-08
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleComprehensive Screening for Naturally Occurring Hepatitis C Virus Resistance to Direct-Acting Antivirals in the NS3, NS5A, and NS5B Genes in Worldwide Isolates of Viral Genotypes 1 to 6
P478volume60

Reverse relations

cites work (P2860)
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Q59358332GP205, a new hepatitis C virus NS3/4A protease inhibitor, displays higher metabolic stability in vitro and drug exposure in vivo
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