Assessing the contribution of interferon antagonism to the virulence of West African Ebola viruses

scientific article published on 5 August 2015

Assessing the contribution of interferon antagonism to the virulence of West African Ebola viruses is …
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scholarly articleQ13442814

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P819ADS bibcode2015NatCo...6.8000D
P6179Dimensions Publication ID1051541768
P356DOI10.1038/NCOMMS9000
P932PMC publication ID4527089
P698PubMed publication ID26242723
P5875ResearchGate publication ID280872411

P50authorHideki EbiharaQ54008242
Eric C DunhamQ55464663
Heinz FeldmannQ60059378
Thomas HoenenQ37378587
P2093author name stringSonja M Best
Allison Groseth
Abhilash I Chiramel
Logan Banadyga
P2860cites workThe Ebola virus glycoprotein contributes to but is not sufficient for virulence in vivoQ21131393
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Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreakQ23000449
Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcomeQ24310145
Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1Q24318342
Ebola haemorrhagic feverQ24629338
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The evolution and genetics of virus host shiftsQ27004307
Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonistQ27472136
Structure of the Ebola VP35 interferon inhibitory domainQ27653329
Mutations Abrogating VP35 Interaction with Double-Stranded RNA Render Ebola Virus Avirulent in Guinea PigsQ27658947
Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35Q27659023
The Ebola Virus Interferon Antagonist VP24 Directly Binds STAT1 and Has a Novel, Pyramidal FoldQ27677595
The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathwayQ27682227
Efficient selection for high-expression transfectants with a novel eukaryotic vectorQ27860810
Ebola virus disease in West Africa--the first 9 months of the epidemic and forward projectionsQ28248431
Myxomatosis in Australia and Europe: a model for emerging infectious diseasesQ28259735
Ebolavirus VP24 binding to karyopherins is required for inhibition of interferon signalingQ33558506
Comparison of the transcription and replication strategies of marburg virus and Ebola virus by using artificial replication systemsQ33653597
The Ebola virus VP24 protein prevents hnRNP C1/C2 binding to karyopherin α1 and partially alters its nuclear import.Q34222991
A novel life cycle modeling system for Ebola virus shows a genome length-dependent role of VP24 in virus infectivityQ34262347
Hiding the evidence: two strategies for innate immune evasion by hemorrhagic fever virusesQ34266468
Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.Q34300832
Global suppression of the host antiviral response by Ebola- and Marburgviruses: increased antagonism of the type I interferon response is associated with enhanced virulenceQ34434866
The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.Q34457606
Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signalingQ34648134
Ebola virus VP24 binds karyopherin alpha1 and blocks STAT1 nuclear accumulationQ34648461
Infection of naive target cells with virus-like particles: implications for the function of ebola virus VP24.Q34717930
Complete genome sequences of three ebola virus isolates from the 2014 outbreak in west AfricaQ34737428
The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3.Q35105093
The Ebolavirus VP24 protein blocks phosphorylation of p38 mitogen-activated protein kinaseQ35299892
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Minigenomes, transcription and replication competent virus-like particles and beyond: reverse genetics systems for filoviruses and other negative stranded hemorrhagic fever virusesQ36650409
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The lack of maturation of Ebola virus-infected dendritic cells results from the cooperative effect of at least two viral domainsQ36978855
Ebolavirus VP35 interacts with the cytoplasmic dynein light chain 8Q37232776
Ebola virus VP35 antagonizes PKR activity through its C-terminal interferon inhibitory domainQ37333731
Evasion of interferon responses by Ebola and Marburg virusesQ37582945
Homo-oligomerization facilitates the interferon-antagonist activity of the ebolavirus VP35 protein.Q38287391
The role of oligomerization for the biological functions of the arenavirus nucleoproteinQ39171988
Basic residues within the ebolavirus VP35 protein are required for its viral polymerase cofactor functionQ39671255
Both matrix proteins of Ebola virus contribute to the regulation of viral genome replication and transcriptionQ39707380
Ebola virus VP35 interaction with dynein LC8 regulates viral RNA synthesis.Q39796673
Ebola virus (EBOV) VP24 inhibits transcription and replication of the EBOV genomeQ40042116
Regions in Ebola virus VP24 that are important for nucleocapsid formationQ40042130
Genetic diversity and evolutionary dynamics of Ebola virus in Sierra LeoneQ40156229
Virology. Mutation rate and genotype variation of Ebola virus from Mali case sequencesQ40163432
The ebolavirus VP24 interferon antagonist: know your enemyQ40271104
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectOrthoebolavirus zairenseQ10538943
P304page(s)8000
P577publication date2015-08-05
P1433published inNature CommunicationsQ573880
P1476titleAssessing the contribution of interferon antagonism to the virulence of West African Ebola viruses
P478volume6