Mislocalization and degradation of human P23H-rhodopsin-GFP in a knockin mouse model of retinitis pigmentosa

scientific article published on 28 December 2011

Mislocalization and degradation of human P23H-rhodopsin-GFP in a knockin mouse model of retinitis pigmentosa is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1167/IOVS.11-8654
P932PMC publication ID3341127
P698PubMed publication ID22110080
P5875ResearchGate publication ID51823639

P50authorTheodore G. WenselQ42403865
P2093author name stringJohn H Wilson
Samuel M Wu
Fung Chan
Brandee A Price
Ivette M Sandoval
David L Simons
P2860cites workRhodopsin accumulation at abnormal sites in retinas of mice with a human P23H rhodopsin transgeneQ72805174
Retinopathy induced in mice by targeted disruption of the rhodopsin geneQ73040800
Opsin localization and rhodopsin photochemistry in a transgenic mouse model of retinitis pigmentosaQ77363247
Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosaQ28115055
Engineering mouse chromosomes with Cre-loxP: range, efficiency, and somatic applicationsQ28141304
IRE1 signaling affects cell fate during the unfolded protein responseQ29615502
Retinitis pigmentosaQ29616538
Mutant rhodopsin transgene expression on a null backgroundQ32061915
Novel rhodopsin mutations Gly114Val and Gln184Pro in dominant retinitis pigmentosa.Q33916106
The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation.Q34135152
A point mutation of the rhodopsin gene in one form of retinitis pigmentosaQ34168407
Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutationsQ34695879
Preparation and properties of phospholipid bilayers containing rhodopsinQ34729108
Knock-in human rhodopsin-GFP fusions as mouse models for human disease and targets for gene therapyQ34836312
Morphological, physiological, and biochemical changes in rhodopsin knockout miceQ34853562
Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosaQ34951881
AAV delivery of wild-type rhodopsin preserves retinal function in a mouse model of autosomal dominant retinitis pigmentosaQ35092388
Efficient mutagenesis of the rhodopsin gene in rod photoreceptor neurons in miceQ35153494
The nature of dominant mutations of rhodopsin and implications for gene therapyQ35566986
Simulation of human autosomal dominant retinitis pigmentosa in transgenic mice expressing a mutated murine opsin geneQ36361102
Regulation of sorting and post-Golgi trafficking of rhodopsin by its C-terminal sequence QVS(A)PA.Q37478322
Characterization of rhodopsin P23H-induced retinal degeneration in a Xenopus laevis model of retinitis pigmentosaQ40249918
Structure and function in rhodopsin. 7. Point mutations associated with autosomal dominant retinitis pigmentosaQ41467175
Defective phototransductive disk membrane morphogenesis in transgenic mice expressing opsin with a mutated N-terminal domain.Q42447195
A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome systemQ44045954
Retinoids assist the cellular folding of the autosomal dominant retinitis pigmentosa opsin mutant P23H.Q44760460
Differential oocyte-specific expression of Cre recombinase activity in GDF-9-iCre, Zp3cre, and Msx2Cre transgenic mice.Q44950379
Mouse opsin. Gene structure and molecular basis of multiple transcriptsQ48247850
Defective development of photoreceptor membranes in a mouse model of recessive retinal degeneration.Q50715249
Structural and functional rescue of murine rod photoreceptors by human rhodopsin transgene.Q52535368
Light-induced acceleration of photoreceptor degeneration in transgenic mice expressing mutant rhodopsinQ71007252
Functional abnormalities in transgenic mice expressing a mutant rhodopsin geneQ72410745
P4510describes a project that usesImageJQ1659584
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectretinitis pigmentosaQ847057
P304page(s)9728-9736
P577publication date2011-12-28
P1433published inInvestigative Ophthalmology Visual ScienceQ6060707
P1476titleMislocalization and degradation of human P23H-rhodopsin-GFP in a knockin mouse model of retinitis pigmentosa
P478volume52

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cites work (P2860)
Q91866889A Novel Mouse Model of MYO7A USH1B Reveals Auditory and Visual System Haploinsufficiencies
Q39052548A Pro23His mutation alters prenatal rod photoreceptor morphology in a transgenic swine model of retinitis pigmentosa.
Q59330365ADP-Ribosylation Factor-Like 2 (ARL2) regulates cilia stability and development of outer segments in rod photoreceptor neurons
Q34267941Abrupt onset of mutations in a developmentally regulated gene during terminal differentiation of post-mitotic photoreceptor neurons in mice
Q41941697Assessing the correlation between mutant rhodopsin stability and the severity of retinitis pigmentosa
Q43116400Can fly photoreceptors lead to treatments for rho ((P23H)) -linked retinitis pigmentosa?
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Q53611722Dominant and recessive mutations in rhodopsin activate different cell death pathways.
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Q38327842Fluorescent knock-in mice to decipher the physiopathological role of G protein-coupled receptors
Q35968065Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development
Q36271072Misfolded opsin mutants display elevated β-sheet structure
Q89064003Misfolded rhodopsin mutants display variable aggregation properties
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Q37619284P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis
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Q40511870Prenatal Exposure to Curcumin Protects Rod Photoreceptors in a Transgenic Pro23His Swine Model of Retinitis Pigmentosa
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Q55333805Tissue inhibitor of metalloproteinases 1 enhances rod survival in the rd1 mouse retina.
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Q36803227Two-Step Reactivation of Dormant Cones in Retinitis Pigmentosa
Q41881511Wild-type opsin does not aggregate with a misfolded opsin mutant

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