The effect of K201 on isolated working rabbit heart mechanical function during pharmacologically induced Ca2+ overload.

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The effect of K201 on isolated working rabbit heart mechanical function during pharmacologically induced Ca2+ overload. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1476-5381.2011.01531.X
P932PMC publication ID3346243
P698PubMed publication ID21658026
P5875ResearchGate publication ID51205541

P50authorChristopher M. LoughreyQ55507536
P2093author name stringA Kelly
G L Smith
R Matsuda
N Kaneko
E B Elliott
P2860cites workEnhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failureQ24530067
Measurement of cardiac function using pressure-volume conductance catheter technique in mice and ratsQ24648818
K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 associationQ24684879
Catecholaminergic polymorphic ventricular tachycardiaQ28287523
Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing heartsQ28300366
In the RyR2(R4496C) mouse model of CPVT, β-adrenergic stimulation induces Ca waves by increasing SR Ca content and not by decreasing the threshold for Ca wavesQ34145105
Guide to Receptors and Channels (GRAC), 5th editionQ34228968
Defective regulation of interdomain interactions within the ryanodine receptor plays a key role in the pathogenesis of heart failureQ34427871
JTV-519, a novel cardioprotective agent, improves the contractile recovery after ischaemia-reperfusion in coronary perfused guinea-pig ventricular musclesQ35042356
What mechanisms underlie diastolic dysfunction in heart failure?Q35817478
Acute beta-adrenergic overload produces myocyte damage through calcium leakage from the ryanodine receptor 2 but spares cardiac stem cellsQ36513042
New cardioprotective agent K201 is natriuretic and glomerular filtration rate enhancingQ37108098
Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.Q43191839
FKBP12.6-mediated stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failureQ44292820
Elevated sarcoplasmic reticulum Ca2+ leak in intact ventricular myocytes from rabbits in heart failureQ44567724
Analysis of ex vivo left ventricular pressure-volume relations in the isolated murine ejecting heartQ44927138
The left ventricular dP/dtmax-end-diastolic volume relation in closed-chest dogsQ45297836
Left ventricular pressure-volume relationship in conscious miceQ46163566
Linearity, load dependence, hysteresis, and clinical associations of systolic and diastolic indices of left ventricular function in man. Multicenter Study of Perioperative Ischemia (McSPI) Research GroupQ46803933
Purification of cardiac annexin V from the beagle dog heart and changes in its localization in the ischemic rat heartQ48212761
Reducing ryanodine receptor open probability as a means to abolish spontaneous Ca2+ release and increase Ca2+ transient amplitude in adult ventricular myocytes.Q48708332
Effects of a novel cardioprotective drug, JTV-519, on membrane currents of guinea pig ventricular myocytes.Q51461343
Effects of JTV-519, a novel anti-ischaemic drug, on the delayed rectifier K+ current in guinea-pig ventricular myocytes.Q54045589
Overexpression of FK-506 binding protein 12.0 modulates excitation contraction coupling in adult rabbit ventricular cardiomyocytesQ64376978
Relation of mitochondrial and cytosolic free calcium to cardiac myocyte recovery after exposure to anoxiaQ68010646
Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibresQ68251468
Consequences of uncontrolled calcium entry and its prevention with calcium antagonistsQ71166713
Effect of pressure development on oxygen consumption by isolated rat heartQ72218889
Effect of a novel cardioprotective agent, JTV-519, on metabolism, contraction and relaxation in the ischemia-reperfused rabbit heartQ73143851
The cardioprotective effects of a new 1,4-benzothiazepine derivative, JTV519, on ischemia/reperfusion-induced Ca2+ overload in isolated rat heartsQ73255225
Inhibition of annexin V-dependent Ca2+ movement in large unilamellar vesicles by K201, a new 1,4-benzothiazepine derivativeQ73893111
Protective effect of JTV519 on prolonged myocardial preservationQ74617146
Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction: implications for systolic and diastolic reserve limitationsQ78961041
K201, a multi-channel blocker, inhibits clofilium-induced torsades de pointes and attenuates an increase in repolarizationQ79368207
K201 modulates excitation-contraction coupling and spontaneous Ca2+ release in normal adult rabbit ventricular cardiomyocytesQ80650258
P433issue4b
P407language of work or nameEnglishQ1860
P304page(s)1068-1083
P577publication date2012-02-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleThe effect of K201 on isolated working rabbit heart mechanical function during pharmacologically induced Ca2+ overload
P478volume165

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cites work (P2860)
Q38195149Heart failure with preserved ejection fraction: a clinical dilemma
Q43965433Heart failure with preserved ejection fraction: future directions in medical treatment
Q36739360Specific nephrotoxicity and cardiotoxicity of BT-CAL®, Sigma Anti-bonding Molecule Calcium Carbonate, in mice

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