Adalimumab alone and in combination with disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis in clinical practice: the Research in Active Rheumatoid Arthritis (ReAct) trial

scientific article

Adalimumab alone and in combination with disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis in clinical practice: the Research in Active Rheumatoid Arthritis (ReAct) trial is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1136/ARD.2006.066761
P932PMC publication ID1954645
P698PubMed publication ID17329305
P5875ResearchGate publication ID6477890

P50authorKristina UnnebrinkQ42572520
Gerd-Rüdiger BurmesterQ47261275
Carlomaurizio MontecuccoQ47265945
Athanasios George TzioufasQ92673448
Xavier MarietteQ93104907
P2093author name stringMichel Malaise
Johannes W J Bijlsma
Hartmut Kupper
Sonja Kary
Kristina Unnebrink
Indalecio Monteagudo-Sáez
P2860cites workThe american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisQ27860872
Classic disease modifying anti-rheumatic drugs (DMARDs) in combination with infliximab. The Finnish experience.Q30351543
Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trialsQ33243658
Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritisQ34315745
Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritisQ34498486
Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trialQ34530459
Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: a randomized, placebo-contQ34547981
Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis. Comparison with the preliminary American College of Rheumatology and the World Health Organization/International League Against RheumatiQ34662758
Frequency of infection in patients with rheumatoid arthritis compared with controls: a population-based studyQ34923104
Infliximab treatment in combination with cyclosporin A in patients with severe refractory rheumatoid arthritisQ35551880
Efficacy and safety of adalimumab as monotherapy in patients with rheumatoid arthritis for whom previous disease modifying antirheumatic drug treatment has failedQ35554130
Haematopoietic malignancies in rheumatoid arthritis: lymphoma risk and characteristics after exposure to tumour necrosis factor antagonistsQ35554823
Risks of solid cancers in patients with rheumatoid arthritis and after treatment with tumour necrosis factor antagonistsQ35554865
Tumour necrosis factor blockers do not increase overall tumour risk in patients with rheumatoid arthritis, but may be associated with an increased risk of lymphomasQ35555527
Safety analyses of adalimumab (HUMIRA) in global clinical trials and US postmarketing surveillance of patients with rheumatoid arthritisQ35637322
Etanercept and sulfasalazine, alone and combined, in patients with active rheumatoid arthritis despite receiving sulfasalazine: a double-blind comparisonQ35637985
Efficacy and safety of combination etanercept and methotrexate versus etanercept alone in patients with rheumatoid arthritis with an inadequate response to methotrexate: the ADORE studyQ35638208
The benefit/risk profile of TNF-blocking agents: findings of a consensus panelQ36155477
Use of combination of leflunomide with biological agents in treatment of rheumatoid arthritisQ36217646
A Norwegian DMARD register: prescriptions of DMARDs and biological agents to patients with inflammatory rheumatic diseases.Q40374563
Predictors of infection in rheumatoid arthritisQ40629895
Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine, or a combination of the three medications: results of a two-year, randomized, double-blind, placebo-controlled trialQ41917264
Etanercept in combination with sulfasalazine, hydroxychloroquine, or gold in the treatment of rheumatoid arthritis.Q41946251
Longterm safety, efficacy, and radiographic outcome with etanercept treatment in patients with early rheumatoid arthritisQ44003346
The rheumatoid arthritis patient in the clinic: comparing more than 1,300 consecutive DMARD coursesQ44240544
Safety of leflunomide plus infliximab combination therapy in rheumatoid arthritis.Q44896512
Infections in patients with rheumatoid arthritis treated with biologic agentsQ44952372
The influence of previous and concomitant leflunomide on the efficacy and safety of infliximab therapy in patients with rheumatoid arthritis; a longitudinal observational studyQ45187063
Effectiveness of recommendations to prevent reactivation of latent tuberculosis infection in patients treated with tumor necrosis factor antagonistsQ46525959
Treatment for rheumatoid arthritis and the risk of hospitalization for pneumonia: associations with prednisone, disease-modifying antirheumatic drugs, and anti-tumor necrosis factor therapyQ46919825
American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritisQ47643186
Sustained improvement over two years in physical function, structural damage, and signs and symptoms among patients with rheumatoid arthritis treated with infliximab and methotrexateQ47784405
Death rates and causes of death in patients with rheumatoid arthritis: a population-based studyQ47926341
Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis: two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized trial.Q50779374
Risk and case characteristics of tuberculosis in rheumatoid arthritis associated with tumor necrosis factor antagonists in SwedenQ57350007
Comparison of the response to infliximab or etanercept monotherapy with the response to cotherapy with methotrexate or another disease-modifying antirheumatic drug in patients with rheumatoid arthritis: Results from the British Society for RheumatoloQ57751349
The dimensions of health outcomes: the health assessment questionnaire, disability and pain scalesQ70606503
Remission in rheumatoid arthritis: agreement of the disease activity score (DAS28) with the ARA preliminary remission criteriaQ80298150
The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not hadQ82132610
Cyclosporine in addition to infliximab and methotrexate in refractory rheumatoid arthritisQ82190685
Safety of infliximab used in combination with leflunomide or azathioprine in daily clinical practiceQ83230837
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectrheumatoid arthritisQ187255
adalimumabQ348260
P304page(s)732-739
P577publication date2007-02-28
P1433published inAnnals of the Rheumatic DiseasesQ4767876
P1476titleAdalimumab alone and in combination with disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis in clinical practice: the Research in Active Rheumatoid Arthritis (ReAct) trial
P478volume66

Reverse relations

cites work (P2860)
Q432809062-Acylaminopyridin-4-ylimidazoles as p38 MAP kinase inhibitors: Design, synthesis, and biological and metabolic evaluations
Q48252129Abatacept used in combination with non-methotrexate disease-modifying antirheumatic drugs: a descriptive analysis of data from interventional trials and the real-world setting.
Q28282655Adalimumab for the treatment of rheumatoid arthritis
Q38192659Adalimumab in the treatment of rheumatoid arthritis
Q27691822Advances in the treatment of rheumatoid arthritis.
Q44518151Analysis of infections and all-cause mortality in phase II, phase III, and long-term extension studies of tofacitinib in patients with rheumatoid arthritis
Q38096206Biological therapies for rheumatoid arthritis: progress to date
Q82332974CD11c as a transcriptional biomarker to predict response to anti-TNF monotherapy with adalimumab in patients with rheumatoid arthritis
Q37728019Clinical application and evaluation of anti-TNF-alpha agents for the treatment of rheumatoid arthritis
Q37157407Clinical investigation in highly disease-affected rheumatoid arthritis patients in Japan with adalimumab applying standard and general evaluation: the CHANGE study
Q38236144Clinical parameters and biomarkers for anti-TNF treatment prognosis in rheumatoid arthritis patients
Q43191366Comparison of combination therapies in the treatment of rheumatoid arthritis: leflunomide-anti-TNF-alpha versus methotrexate-anti-TNF-alpha
Q35143956Comparison of tocilizumab as monotherapy or with add-on disease-modifying antirheumatic drugs in patients with rheumatoid arthritis and inadequate responses to previous treatments: an open-label study close to clinical practice.
Q33486150DAS-28-based EULAR response and HAQ improvement in rheumatoid arthritis patients switching between TNF antagonists
Q57177877Decreased IgG4 ACPA levels in responders and increased CD1c classical dendritic cells in non-responders of patients with rheumatoid arthritis under therapy
Q36577308Do patients with active RA have differences in disease activity and perceptions if anti-TNF naïve versus anti-TNF experienced? Baseline results of the optimization of adalimumab trial
Q34081925Drug-specific risk of tuberculosis in patients with rheumatoid arthritis treated with anti-TNF therapy: results from the British Society for Rheumatology Biologics Register (BSRBR).
Q26859134EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update
Q33566374Effectiveness of adalimumab in treating patients with active psoriatic arthritis and predictors of good clinical responses for arthritis, skin and nail lesions
Q90334891Effectiveness, Tolerability, and Safety of Tofacitinib in Rheumatoid Arthritis: A Retrospective Analysis of Real-World Data from the St. Gallen and Aarau Cohorts
Q48282725Efficacy and safety of adalimumab in Chinese adults with active ankylosing spondylitis: results of a randomised, controlled trial
Q33573112Efficacy and safety of anakinra for the treatment of rheumatoid arthritis: an update of the Oregon Drug Effectiveness Review Project
Q33956485Efficacy and safety of golimumab as add-on therapy to disease-modifying antirheumatic drugs: results of the GO-MORE study
Q42597675Efficacy and safety of leflunomide or methotrexate plus subcutaneous tumour necrosis factor-alpha blocking agents in rheumatoid arthritis
Q37210207Efficacy, safety and patient-reported outcomes of combination etanercept and sulfasalazine versus etanercept alone in patients with rheumatoid arthritis: a double-blind randomised 2-year study
Q38108468Endemic fungal infections in inflammatory bowel disease associated with anti-TNF antibody therapy
Q35620336Evaluating the efficacy of sequential biologic therapies for rheumatoid arthritis patients with an inadequate response to tumor necrosis factor-α inhibitors
Q90911152Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility
Q37206996Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis
Q37786627Golimumab: a new anti-TNF-α agent for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis
Q60919444IRF4 and IRGs Delineate Clinically Relevant Gene Expression Signatures in Systemic Lupus Erythematosus and Rheumatoid Arthritis
Q33984823Impact of patient and disease characteristics on therapeutic success during adalimumab treatment of patients with rheumatoid arthritis: data from a German noninterventional observational study
Q37358271Incidence density of serious infection, opportunistic infection, and tuberculosis associated with biologic treatment in patients with rheumatoid arthritis - a systematic evaluation of the literature
Q37156636Infectious complications associated with monoclonal antibodies and related small molecules
Q46153168Leflunomide in combination with TNF-blockers for Methotrexate intolerance
Q35110153Lipid peroxidation-mediated inflammation promotes cell apoptosis through activation of NF-κB pathway in rheumatoid arthritis synovial cells
Q37358124Long-term use of adalimumab in the treatment of rheumatic diseases.
Q42442252Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis
Q37832130Monoclonal antibody therapy-associated neurological disorders
Q36633367Monocyte populations as markers of response to adalimumab plus MTX in rheumatoid arthritis.
Q88239772Origins of Discordant Responses among 3 Rheumatoid Arthritis Improvement Criteria
Q86934388Patterns of use and dosing of tocilizumab in the treatment of patients with rheumatoid arthritis in routine clinical practice: the ACT-LIFE study
Q47136253Predictor of the Simplified Disease Activity Index 50 (SDAI 50) at Month 3 of bDMARD Treatment in Patients with Long-Established Rheumatoid Arthritis
Q34413310Rapid and sustained improvements in health-related quality of life, fatigue, and other patient-reported outcomes in rheumatoid arthritis patients treated with certolizumab pegol plus methotrexate over 1 year: results from the RAPID 1 randomized cont
Q37358239Reappraisal of the clinical use of leflunomide in rheumatoid arthritis and psoriatic arthritis
Q34114195Reduction in sickness absence in patients with rheumatoid arthritis receiving adalimumab: data from a German noninterventional study
Q40315731Rheumatoid arthritis complicated with immunodeficiency-associated lymphoproliferative disorders during treatment with adalimumab
Q37294842Rheumatoid arthritis synovial fibroblasts produce a soluble form of the interleukin-7 receptor in response to pro-inflammatory cytokines
Q30244019Rheumatoid arthritis.
Q26991673Risk of tuberculosis in patients with chronic immune-mediated inflammatory diseases treated with biologics and tofacitinib: a systematic review and meta-analysis of randomized controlled trials and long-term extension studies
Q34065405Risk of tuberculosis is higher with anti-tumor necrosis factor monoclonal antibody therapy than with soluble tumor necrosis factor receptor therapy: The three-year prospective French Research Axed on Tolerance of Biotherapies registry
Q37691205Safety and effectiveness of adalimumab in patients with rheumatoid arthritis over 5 years of therapy in a phase 3b and subsequent postmarketing observational study
Q37894193TNF alpha antagonist therapy and safety monitoring
Q35617753The association between systemic glucocorticoid therapy and the risk of infection in patients with rheumatoid arthritis: systematic review and meta-analyses
Q37728840The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease
Q37804483The effect of immunomodulators on the immunogenicity of TNF-blocking therapeutic monoclonal antibodies: a review
Q38129037The role of DMARDs in reducing the immunogenicity of TNF inhibitors in chronic inflammatory diseases.
Q38173669The safety of biologic therapies in RA-associated interstitial lung disease
Q92627208The use of biological disease-modifying antirheumatic drugs for inflammatory arthritis in Korea: results of a Korean Expert Consensus
Q36679764Tocilizumab in patients with active rheumatoid arthritis and inadequate responses to DMARDs and/or TNF inhibitors: a large, open-label study close to clinical practice
Q50703895Tocilizumab is clinically, functionally, and radiographically effective and safe either with or without low-dose methotrexate in active rheumatoid arthritis patients with inadequate responses to DMARDs and/or TNF inhibitors: a single-center retrospe
Q54978346Tofacitinib 5 mg Twice Daily in Patients with Rheumatoid Arthritis and Inadequate Response to Disease-Modifying Antirheumatic Drugs: A Comprehensive Review of Phase 3 Efficacy and Safety.
Q36823592Treating psoriasis with adalimumab.
Q47132835Treatment with Biologicals in Rheumatoid Arthritis: An Overview.
Q37802766Tuberculosis and anti-TNF treatment: experience of a central London hospital
Q30799235Tuberculosis risk and anti-tumour necrosis factor agents in rheumatoid arthritis: a critical appraisal of national registry data
Q34818636Update on the safety profile of certolizumab pegol in rheumatoid arthritis: an integrated analysis from clinical trials
Q37207061Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA study
Q82719630[Infectious complications of biologic therapy in patients with rheumatoid arthritis]
Q38207759anti-TNF agents as therapeutic choice in immune-mediated inflammatory diseases: focus on adalimumab.

Search more.