IQGAP1 and IQGAP3 Serve Individually Essential Roles in Normal Epidermal Homeostasis and Tumor Progression

scientific article

IQGAP1 and IQGAP3 Serve Individually Essential Roles in Normal Epidermal Homeostasis and Tumor Progression is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/JID.2015.140
P932PMC publication ID4537348
P698PubMed publication ID25848980

P50authorTodd W RidkyQ42882487
Emily F SchapiraQ87635231
P2093author name stringSeung J Oh
Elizabeth K Duperret
Andrew McNeal
Christine L Monteleon
P2860cites workMAPK scaffold IQGAP1 binds the EGF receptor and modulates its activationQ24294200
IQGAP proteins are integral components of cytoskeletal regulationQ24535739
Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1Q24554337
IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesisQ24655426
Genomic analysis of metastasis reveals an essential role for RhoCQ28144278
Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170Q28213976
Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: its overexpression in carcinomas and association with invasion frontsQ28215481
Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathwayQ28237113
IQGAP1 regulation and roles in cancerQ28237517
IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascadeQ28510385
Use of human tissue to assess the oncogenic activity of melanoma-associated mutationsQ34716087
IQGAP1 and its binding proteins control diverse biological functionsQ35713259
Protein scaffolds in MAP kinase signallingQ37156628
A genecentric Human Protein Atlas for expression profiles based on antibodiesQ37231349
Metalloproteinase-mediated, context-dependent function of amphiregulin and HB-EGF in human keratinocytes and skin.Q37480932
IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors.Q39163078
Rapid production of retroviruses for efficient gene delivery to mammalian cells using 293T cell-based systemsQ39989137
Activating FGFR3 mutations cause mild hyperplasia in human skin, but are insufficient to drive benign or malignant skin tumors.Q40465847
Invasive three-dimensional organotypic neoplasia from multiple normal human epitheliaQ41681817
Targeted disruption of the epidermal growth factor receptor impairs growth of squamous papillomas expressing the v-ras(Ha) oncogene but does not block in vitro keratinocyte responses to oncogenic rasQ42442094
CDK4 coexpression with Ras generates malignant human epidermal tumorigenesisQ46492957
P433issue9
P407language of work or nameEnglishQ1860
P921main subjecttumor progressionQ16909647
P304page(s)2258-2265
P577publication date2015-04-07
P1433published inJournal of Investigative DermatologyQ3186921
P1476titleIQGAP1 and IQGAP3 Serve Individually Essential Roles in Normal Epidermal Homeostasis and Tumor Progression
P478volume135

Reverse relations

cites work (P2860)
Q90615917A PI3K/AKT Scaffolding Protein, IQ Motif-Containing GTPase Associating Protein 1 (IQGAP1), Promotes Head and Neck Carcinogenesis
Q38729859Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases.
Q48337840Circular RNAs are abundantly expressed and upregulated during human epidermal stem cell differentiation
Q64938888Clinical value of detecting IQGAP3, B7-H4 and cyclooxygenase-2 in the diagnosis and prognostic evaluation of colorectal cancer.
Q36285709Focal-adhesion-independent integrin-αv regulation of FAK and c-Myc is necessary for 3D skin formation and tumor invasion
Q38723812IQ-domain GTPase-activating protein 1 promotes the malignant phenotype of invasive ductal breast carcinoma via canonical Wnt pathway
Q37553772Overexpression and biological function of IQGAP3 in human pancreatic cancer
Q38372346Role of IQGAP3 in metastasis and epithelial-mesenchymal transition in human hepatocellular carcinoma
Q36892005Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors
Q42389141The integrin αv-TGFβ signaling axis is necessary for epidermal proliferation during cutaneous wound healing

Search more.