MiR144/451 Expression Is Repressed by RUNX1 During Megakaryopoiesis and Disturbed by RUNX1/ETO.

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MiR144/451 Expression Is Repressed by RUNX1 During Megakaryopoiesis and Disturbed by RUNX1/ETO. is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PGEN.1005946
P932PMC publication ID4798443
P698PubMed publication ID26990877
P5875ResearchGate publication ID298904252

P50authorGabriela Salinas-RiesterQ84916358
Uwe PlatzbeckerQ71792160
P2093author name stringThomas Lingner
Manuel Grez
Erhard Seifried
Olga N Kuvardina
Hind Medyouf
Christian Wichmann
Jörn Lausen
Halvard Bonig
Julia Herglotz
Alexander Piechatzek
Jasmin Yillah
Nicole Kohrs
Stefanie Herkt
Stephan Kolodziej
P2860cites workGATA-1 forms distinct activating and repressive complexes in erythroid cellsQ24303958
Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressorsQ24316983
The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcriptQ24564573
miR-451 protects against erythroid oxidant stress by repressing 14-3-3zetaQ24600133
Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zetaQ24600228
The miR-144/451 locus is required for erythroid homeostasisQ24615624
Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesisQ24621611
miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2Q24648416
MicroRNA 223-dependent expression of LMO2 regulates normal erythropoiesisQ24649761
MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitorsQ24653639
The human genome browser at UCSCQ24672361
MicroRNAs are shaping the hematopoietic landscapeQ27027663
Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runtQ28189555
Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysisQ28265897
A dicer-independent miRNA biogenesis pathway that requires Ago catalysisQ28508177
SCL and associated proteins distinguish active from repressive GATA transcription factor complexesQ28591576
RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiationQ30310497
Erythroid inhibition by the leukemic fusion AML1-ETO is associated with impaired acetylation of the major erythroid transcription factor GATA-1.Q30439786
Histone arginine methylation keeps RUNX1 target genes in an intermediate stateQ32884565
Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse.Q33758222
AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutationsQ33943238
miR-451 enhances erythroid differentiation in K562 cellsQ34103179
miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets.Q34113773
Expression of microRNA-451 in normal and thalassemic erythropoiesis.Q34114838
MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulationQ34212635
Down-regulation of microRNAs 222/221 in acute myelogenous leukemia with deranged core-binding factor subunitsQ34300594
MicroRNA expression in maturing murine megakaryocytesQ34450782
Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expressionQ34543370
RUNX1 repression-independent mechanisms of leukemogenesis by fusion genes CBFB-MYH11 and AML1-ETO (RUNX1-RUNX1T1).Q34621037
Expression patterns of microRNAs 155 and 451 during normal human erythropoiesisQ34707255
Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cellsQ34707310
Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein.Q34712578
miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53.Q34991097
MIR144 and MIR451 regulate human erythropoiesis via RAB14Q35039945
Identification of a dynamic core transcriptional network in t(8;21) AML that regulates differentiation block and self-renewalQ35806108
Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.Q36166902
Overexpression and knockout of miR-126 both promote leukemogenesisQ36193187
RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesisQ36206674
AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiencyQ36371457
Attenuation of miR-126 activity expands HSC in vivo without exhaustion.Q36455274
A GATA-1-regulated microRNA locus essential for erythropoiesisQ36491071
Tal1 regulates osteoclast differentiation through suppression of the master regulator of cell fusion DC-STAMPQ85077877
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.Q52111650
RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription.Q52570374
MicroRNA-451 suppresses tumor cell growth by down-regulating IL6R gene expression.Q53243362
Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse modelQ57615605
Primitive erythropoiesis in the Xenopus embryo: the synergistic role of LMO-2, SCL and GATA-binding proteinsQ74330636
Cell cycle and developmental control of hematopoiesis by Runx1.Q36543603
miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem CellsQ36568466
Distinct microRNA expression profiles in acute myeloid leukemia with common translocations.Q36926841
A regulatory interplay between miR-27a and Runx1 during megakaryopoiesisQ37032568
AML1/RUNX1 works as a negative regulator of c-Mpl in hematopoietic stem cellsQ37142554
Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.Q37589404
t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1Q37627380
Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia developmentQ37704913
Molecular targeting of aberrant transcription factors in leukemia: strategies for RUNX1/ETO.Q37768185
Hematopoietic stem cell emergence in the conceptus and the role of Runx1.Q37780164
AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approachesQ38033116
RUNX1: A microRNA hub in normal and malignant hematopoiesisQ38076281
A role for RUNX1 in hematopoiesis and myeloid leukemia.Q38101285
Contributions of the histone arginine methyltransferase PRMT6 to the epigenetic function of RUNX1.Q38123541
microRNAs in hematopoiesis.Q38246372
Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemiaQ38287713
A novel complex, RUNX1-MYEF2, represses hematopoietic genes in erythroid cellsQ38323565
A multicolor panel of novel lentiviral "gene ontology" (LeGO) vectors for functional gene analysis.Q38514169
miR-17 deregulates a core RUNX1-miRNA mechanism of CBF acute myeloid leukemiaQ38917442
miRNAs: a new method for erythroid differentiation of hematopoietic stem cells without the presence of growth factors.Q39044656
Addiction of t(8;21) and inv(16) acute myeloid leukemia to native RUNX1.Q39093568
MicroRNA-34a inhibits cell proliferation by repressing mitogen-activated protein kinase kinase 1 during megakaryocytic differentiation of K562 cellsQ39726018
Thrombopoietin regulates c-Myb expression by modulating micro RNA 150 expressionQ39936227
A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesisQ40246641
Histone deacetylase inhibitors induce the degradation of the t(8;21) fusion oncoproteinQ40262839
The nuclear receptor co-repressor (N-CoR) utilizes repression domains I and III for interaction and co-repression with ETO.Q40514072
RUNX1 represses the erythroid gene expression program during megakaryocytic differentiationQ41015953
Dynamics of alpha-globin locus chromatin structure and gene expression during erythroid differentiation of human CD34(+) cells in cultureQ41194034
A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activityQ41845562
Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cellsQ42025646
The truncated RUNX1/ETO activates VLA-4-dependent adhesion and migration of hematopoietic progenitor cellsQ43057950
A genetic strategy for single and combinatorial analysis of miRNA function in mammalian hematopoietic stem cellsQ43242908
The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cellsQ44189646
AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cellsQ44248072
Using TESS to predict transcription factor binding sites in DNA sequenceQ44375395
Runx1 is expressed in adult mouse hematopoietic stem cells and differentiating myeloid and lymphoid cells, but not in maturing erythroid cellsQ44780658
AML1/ETO promotes the maintenance of early hematopoietic progenitors in NOD/SCID mice but does not abrogate their lineage specific differentiationQ45204173
High-level transduction and gene expression in hematopoietic repopulating cells using a human immunodeficiency [correction of imunodeficiency] virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoterQ45732758
In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemiaQ46139535
AML1-ETO9a is correlated with C-KIT overexpression/mutations and indicates poor disease outcome in t(8;21) acute myeloid leukemia-M2.Q47754436
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P304page(s)e1005946
P577publication date2016-03-18
P1433published inPLOS GeneticsQ1893441
P1476titleMiR144/451 Expression Is Repressed by RUNX1 During Megakaryopoiesis and Disturbed by RUNX1/ETO.
P478volume12

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cites work (P2860)
Q90859356Compatibility of RUNX1/ETO fusion protein modules driving CD34+ human progenitor cell expansion
Q42700903Hematopoietic transcription factors and differential cofactor binding regulate PRKACB isoform expression
Q42696672Protein arginine methyltransferase 6 controls erythroid gene expression and differentiation of human CD34+ progenitor cells
Q91813308RUNX1 inhibits proliferation and induces apoptosis of t(8;21) leukemia cells via KLF4-mediated transactivation of P57
Q47097926RUNX1 promote invasiveness in pancreatic ductal adenocarcinoma through regulating miR-93.

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