Pharmacokinetics of antiretrovirals in pregnant women

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Pharmacokinetics of antiretrovirals in pregnant women is …
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scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1021251857
P356DOI10.2165/00003088-200443150-00002
P698PubMed publication ID15568888

P50authorEdmund CapparelliQ87605095
P2093author name stringMark Mirochnick
P2860cites workThe effect of zidovudine dose on the formation of intracellular phosphorylated metabolitesQ71746290
Review of beta-lactam antibiotics in pregnancy. The need for adjustment of dosage schedulesQ72793341
The maternal-fetal transfer of lamivudine in the ex vivo human placentaQ73143771
Low plasma concentrations of indinavir are related to virological treatment failure in HIV-1-infected patients on indinavir-containing triple therapyQ73464193
Single dose pharmacokinetics and bioavailability of nevirapine in healthy volunteersQ73508511
Oral zidovudine during labor to prevent perinatal HIV transmission, Bangkok: tolerance and zidovudine concentration in cord blood. Bangkok Collaborative Perinatal HIV Transmission Study GroupQ73711293
Induction of CYP2D6 in pregnancyQ73846474
Pharmacokinetics of indinavir in HIV-positive pregnant womenQ73896502
Pharmacological implications of lengthened in-utero exposure to nevirapineQ74023464
Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptaseQ24629039
Management of human immunodeficiency virus infection in pregnancyQ28204446
Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study GroupQ28239283
1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activityQ28378894
Prevention of mother-to-child HIV transmission in resource-poor countries: translating research into policy and practice.Q30326359
Pharmacokinetics during pregnancy: evidence-based maternal dose formulationQ30888520
Clinical pharmacokinetics of zidovudine. An overview of current dataQ31030044
Maternal-fetal transfer and amniotic fluid accumulation of lamivudine in human immunodeficiency virus-infected pregnant womenQ31928400
Elevated alpha-1-acid glycoprotein reduces the volume of distribution and systemic clearance of saquinavirQ31956952
Nelfinavir mesylate: a protease inhibitorQ33592439
Pharmacokinetics and potential interactions amongst antiretroviral agents used to treat patients with HIV infectionQ33631613
Transplacental pharmacokinetics of dideoxyinosine in pigtailed macaquesQ33752846
Pharmacokinetics of zidovudine phosphorylation in peripheral blood mononuclear cells from patients infected with human immunodeficiency virusQ33754634
AntiretroviralsQ33792042
Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trialQ33873955
Combination antiretroviral strategies for the treatment of pregnant HIV-1-infected women and prevention of perinatal HIV-1 transmissionQ33958839
Pharmacokinetics of zidovudine phosphorylation in human immunodeficiency virus-positive thai patients and healthy volunteersQ33980114
Multiple-dose pharmacokinetics and pharmacodynamics of abacavir alone and in combination with zidovudine in human immunodeficiency virus-infected adultsQ33980172
The use of anticonvulsants during pregnancyQ34308706
Antidepressants during pregnancy and lactation: defining exposure and treatment issuesQ34308727
Elective caesarean-section versus vaginal delivery in prevention of vertical HIV-1 transmission: a randomised clinical trialQ34503010
Two-dose intrapartum/newborn nevirapine and standard antiretroviral therapy to reduce perinatal HIV transmission: a randomized trialQ34719306
Disposition of didanosine in HIV-seropositive patients with normal renal function or chronic renal failure: influence of hemodialysis and continuous ambulatory peritoneal dialysisQ34736674
Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerationsQ34738805
Pharmacokinetics of saquinavir plus low-dose ritonavir in human immunodeficiency virus-infected pregnant womenQ35547832
Acute onset lactic acidosis and pancreatitis in the third trimester of pregnancy in HIV-1 positive women taking antiretroviral medicationQ35572889
The ex vivo human placental transfer of the anti-HIV nucleoside inhibitor abacavir and the protease inhibitor amprenavirQ35615609
Pharmacokinetics of nevirapine: initial single-rising-dose study in humansQ35808226
Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012).Q38884920
A phase I/II study of the safety and pharmacokinetics of nevirapine in HIV-1-infected pregnant Ugandan women and their neonates (HIVNET 006).Q38886823
Interactions of various 19-nor steroids with human placental microsomal cytochrome P-450 (P-450hpm)Q39130612
Plasma protein binding of drugs in pregnancyQ40242706
Cellular pharmacology of 2',3'-dideoxy-2',3'-didehydrothymidine, a nucleoside analog active against human immunodeficiency virusQ40283999
Developmental pharmacology and toxicology of anti‐HIV therapeutic agents: dideoxynucleosides 1Q40481228
In vitro models to predict the in vivo mechanism, rate, and extent of placental transfer of dideoxynucleoside drugs against human immunodeficiency virusQ40827877
Lamivudine. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV infectionQ41429010
Drug disposition in mother and foetusQ41639067
Pharmacokinetic changes during pregnancy and their clinical relevanceQ41657026
Phase I/II evaluation of nevirapine alone and in combination with zidovudine for infection with human immunodeficiency virus.Q42275525
Nucleoside transport by perfused human placentaQ42287353
The pharmacokinetics of lamivudine phosphorylation in peripheral blood mononuclear cells from patients infected with HIV-1.Q42613832
Safety and efficacy of saquinavir soft-gelatin capsules + zidovudine + optional lamivudine in pregnancy and prevention of vertical HIV transmissionQ42681152
Nevirapine pharmacokinetics in pregnant women and in their infants after in utero exposureQ43816558
Pharmacokinetics of saquinavir-SGC in HIV-infected pregnant womenQ43822045
Myelomeningocele in a child with intrauterine exposure to efavirenz.Q43864153
Maternal toxicity with continuous nevirapine in pregnancy: results from PACTG 1022.Q43897601
Transplacental passage of protease inhibitors at deliveryQ43937448
Public Health Service Task Force recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV-1 transmission in the United States (revised November 3, 2000).Q43956302
CD4 response is correlated with peak plasma concentrations of indinavir in adults with undetectable human immunodeficiency virus ribonucleic acidQ43961554
Intracellular carbovir triphosphate levels in patients taking abacavir once a day.Q43988883
Concentrations of protease inhibitors in cord blood after in utero exposureQ44157151
Lopinavir protein binding in vivo through the 12-hour dosing intervalQ44746683
A trial of shortened zidovudine regimens to prevent mother-to-child transmission of human immunodeficiency virus type 1. Perinatal HIV Prevention Trial (Thailand) InvestigatorsQ45740341
Systemic pharmacokinetics and cellular pharmacology of zidovudine in human immunodeficiency virus type 1-infected women and newborn infantsQ45746364
Pharmacokinetics of didanosine in antepartum and postpartum human immunodeficiency virus--infected pregnant women and their neonates: an AIDS clinical trials group studyQ45746870
Pharmacokinetics and antiretroviral activity of lamivudine alone or when coadministered with zidovudine in human immunodeficiency virus type 1-infected pregnant women and their offspringQ45753331
Pharmacokinetics of nevirapine in human immunodeficiency virus type 1-infected pregnant women and their neonates. Pediatric AIDS Clinical Trials Group Protocol 250 TeamQ45754372
The pharmacokinetics and safety of zidovudine in the third trimester of pregnancy for women infected with human immunodeficiency virus and their infants: phase I acquired immunodeficiency syndrome clinical trials group study (protocol 082). ZidovudiQ45779956
Zidovudine response relationships in early human immunodeficiency virus infectionQ45783462
High-dose nevirapine: safety, pharmacokinetics, and antiviral effect in patients with human immunodeficiency virus infectionQ45789390
Transplacental pharmacokinetics and fetal distribution of azidothymidine, its glucuronide, and phosphorylated metabolites in late-term rhesus macaques after maternal infusionQ48746218
Serum protein binding of drugs during and after pregnancy in humans.Q51875039
Pharmacokinetics of didanosine in patients with acquired immunodeficiency syndrome or acquired immunodeficiency syndrome-related complex.Q54078500
Short-course zidovudine for perinatal HIV-1 transmission in Bangkok, Thailand: a randomised controlled trial. Bangkok Collaborative Perinatal HIV Transmission Study GroupQ64131586
Placental passage of azathiothymidine (AZT) during the second trimester of pregnancy: study by direct fetal blood sampling under ultrasoundQ67956898
Pharmacokinetic disposition of zidovudine during pregnancyQ68184172
Zidovudine Pharmacokinetics During PregnancyQ68200727
Characterization of theophylline binding to serum proteins in pregnant and nonpregnant womenQ68692669
Azidothymidine (zidovudine) transport by the human placentaQ68696399
Plasma and cerebrospinal fluid pharmacokinetics of 3'-azido-3'-deoxythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseasesQ68942769
Induction of hepatic enzymes during normal human pregnancyQ69563563
Comparative pharmacokinetics of zidovudine (AZT) and its metabolite (G.AZT) in healthy subjects and HIV seropositive patientsQ69720906
Changes in serum albumin and alpha 1-acid glycoprotein concentrations during pregnancy: an analysis of fetal-maternal pairsQ70613187
Pharmacokinetics of lamivudine administered alone and with trimethoprim-sulfamethoxazoleQ71117298
Drug disposition and pharmacokinetics in the maternal-placental-fetal unitQ71314217
Rapid gentamicin elimination in obstetric patientsQ71374460
P433issue15
P921main subjectpharmacokineticsQ323936
pregnant personQ104720811
anti-retroviral agentQ50430310
P304page(s)1071-1087
P577publication date2004-01-01
P1433published inClinical PharmacokineticsQ5133788
P1476titlePharmacokinetics of antiretrovirals in pregnant women
P478volume43