Strontium ranelate: a novel mode of action leading to renewed bone quality

scientific article

Strontium ranelate: a novel mode of action leading to renewed bone quality is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S00198-004-1809-9
P698PubMed publication ID15578157

P2093author name stringPatrick Ammann
P2860cites workThe effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosisQ28241336
Importance of preclinical studies in the development of drugs for treatment of osteoporosis: a review related to the 1998 WHO guidelinesQ33767974
Sex steroids and the construction and conservation of the adult skeletonQ34131889
Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosisQ34374271
Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research GroupQ34409983
The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitroQ34734649
The effect on vertebral bone mass and strength of long term treatment with antiresorptive agents (estrogen and calcitonin), human parathyroid hormone-(1-38), and combination therapy, assessed in aged ovariectomized ratsQ36747279
Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosisQ37372546
New developments in biochemical markers for osteoporosisQ41282498
Bone mineral density reflects bone mass but also the degree of mineralization of bone: therapeutic implicationsQ41632573
S 12911-2 inhibits osteoclastic bone resorption in vitroQ42443380
Recovery of proximal tibia bone mineral density and strength, but not cancellous bone architecture, after long-term bisphosphonate or selective estrogen receptor modulator therapy in aged ratsQ43855557
Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) InvestigatorsQ43988923
Long-term treatment with strontium ranelate increases vertebral bone mass without deleterious effect in miceQ44037465
In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiationQ44100791
S12911-2 reduces bone loss induced by short-term immobilization in ratsQ44550191
Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female ratsQ45146640
Strontium increases vertebral bone volume in rats at a low dose that does not induce detectable mineralization defectQ46293746
Bone fragility of the peripheral skeleton during fluoride therapy for osteoporosis.Q46398557
Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study GroupQ48527134
Age, gender, and bone lamellae elastic moduli.Q54433580
An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats.Q55066319
Mechanical properties and biochemical composition of rat cortical femur and tibia after long-term treatment with biosynthetic human growth hormoneQ67840012
Fluoride therapy in postmenopausal osteopenic women: Effect on vertebral and femoral bone density and prediction of bone responseQ67857369
Increased incidence of hip fracture in osteoporotic women treated with sodium fluorideQ69623286
Safe and effective treatment of osteoporosis with intermittent slow release sodium fluoride: augmentation of vertebral bone mass and inhibition of fracturesQ69934630
Bone density and shape as determinants of bone strength in IGF-I and/or pamidronate-treated ovariectomized ratsQ71474639
Growth hormone stimulates bone formation and strength of cortical bone in aged ratsQ71549016
Strontium distribution and interactions with bone mineral in monkey iliac bone after strontium salt (S 12911) administrationQ71670564
High fluoride intakes cause osteomalacia and diminished bone strength in rats with renal deficiencyQ71899873
Human parathyroid hormone (1-34) and (1-84) increase the mechanical strength and thickness of cortical bone in ratsQ72600102
IGF-I and pamidronate increase bone mineral density in ovariectomized adult ratsQ72603230
PTH has a more pronounced effect on vertebral bone mass and biomechanical competence than antiresorptive agents (estrogen and bisphosphonate)--assessed in sexually mature, ovariectomized ratsQ72694705
Parathyroid hormone (1-34) and (1-84) stimulate cortical bone formation both from periosteum and endosteumQ72736598
Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic womenQ73150132
The influence of combined parathyroid hormone and growth hormone treatment on cortical bone in aged ovariectomized ratsQ73226238
Heterogeneity of bone lamellar-level elastic moduliQ73835333
Elastic properties of human cortical and trabecular lamellar bone measured by nanoindentationQ73860814
Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal womenQ73911971
Early effects of short-term parathyroid hormone administration on bone mass, mineral content, and strength in female ratsQ74350822
Fluoride salts are no better at preventing new vertebral fractures than calcium-vitamin D in postmenopausal osteoporosis: the FAVOStudyQ74841216
Gain in bone mineral mass in prepubertal girls 3.5 years after discontinuation of calcium supplementation: a follow-up studyQ77053463
Changes in bone density and turnover explain the reductions in incidence of nonvertebral fractures that occur during treatment with antiresorptive agentsQ77878009
Mechanical and morphological variation of the human lumbar vertebral cortical and trabecular boneQ77975436
Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femurQ78222157
P407language of work or nameEnglishQ1860
P921main subjectstrontiumQ938
P304page(s)S11-5
P577publication date2005-01-01
P1433published inOsteoporosis InternationalQ7107640
P1476titleStrontium ranelate: a novel mode of action leading to renewed bone quality
P478volume16 Suppl 1

Reverse relations

cites work (P2860)
Q43159591A novel method for local administration of strontium from implant surfaces
Q39442485A physiologically based pharmacokinetic model for strontium exposure in rat.
Q36752277Anabolic agents and the bone morphogenetic protein pathway
Q51734259Applications of Metals for Bone Regeneration.
Q63991062Cylindrical Layered Bone Scaffolds with Anisotropic Mechanical Properties as Potential Drug Delivery Systems
Q34727815Efficacy of strontium ranelate in combination with a D-hormone analog for the treatment of postmenopausal osteoporosis
Q64237704In vitro cellular testing of strontium/calcium substituted phosphate glass discs and microspheres shows potential for bone regeneration
Q83348229In vitro study in stimulating the secretion of angiogenic growth factors of strontium-doped calcium polyphosphate for bone tissue engineering
Q39737232Osteopenic bone cell response to strontium-substituted hydroxyapatite
Q34340868Strontium is incorporated in different levels into bones and teeth of rats treated with strontium ranelate
Q57162867Strontium ranelate changes the composition and crystal structure of the biological bone-like apatite produced in osteoblast cell cultures
Q37300106Strontium ranelate improves the interaction of osteoblastic cells with titanium substrates: Increase in cell proliferation, differentiation and matrix mineralization
Q39138461Strontium ranelate increases the formation of bone-like mineralized nodules in osteoblast cell cultures and leads to Sr incorporation into the intact nodules
Q31033939Strontium ranelate--data on vertebral and nonvertebral fracture efficacy and safety: mechanism of action
Q39437837Study on bio-corrosion and cytotoxicity of a sr-based bulk metallic glass as potential biodegradable metal.
Q35651890The changes in bone organic and inorganic matrix in newborn rats after maternal application of antiretroviral agents: Indinavir and zidovudine
Q34067224The differences of femoral neck geometric parameters: effects of age, gender and race.

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