The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity

scientific article

The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FMICB.2015.00878
P932PMC publication ID4548080
P698PubMed publication ID26379653
P5875ResearchGate publication ID281240506

P2093author name stringYuri Persidsky
Holly Dykstra
Slava Rom
Nancy L Reichenbach
P2860cites workToll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE.Q37352700
CD4 nadir is a predictor of HIV neurocognitive impairment in the era of combination antiretroviral therapyQ37402458
Effects of PARP-1 deficiency on airway inflammatory cell recruitment in response to LPS or TNF: differential effects on CXCR2 ligands and Duffy Antigen Receptor for ChemokinesQ37429317
The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targetsQ37770152
Gallotannin inhibits the expression of chemokines and inflammatory cytokines in A549 cellsQ38324533
Sera from HIV-1 infected individuals in all stages of disease preferentially recognize the V3 loop of the prototypic macrophage-tropic glycoprotein gp120 ADA.Q38981659
Activation of Cannabinoid Type Two Receptors (CB2) Diminish Inflammatory Responses in Macrophages and Brain EndotheliumQ39077826
Lipopolysaccharide activates ERK-PARP-1-RelA pathway and promotes nuclear factor-κB transcription in murine macrophages.Q39385263
Regulation of CXCR4 conformation by the small GTPase Rac1: implications for HIV infectionQ39413410
Poly(ADP-ribose)polymerase-1 is required for integration of the human immunodeficiency virus type 1 genome near centromeric alphoid DNA in human and murine cellsQ40400793
Poly(ADP-ribose) polymerase-1 is a negative regulator of HIV-1 transcription through competitive binding to TAR RNA with Tat.positive transcription elongation factor b (p-TEFb) complexQ40501267
Evidence for regulation of NF-kappaB by poly(ADP-ribose) polymeraseQ40896649
Poly (ADP-ribose) polymerase is involved in PMA-induced activation of HIV-1 in U1 cells by modulating the LTR function.Q40935198
Nuclear expression of the 50- and 65-kD Rel-related subunits of nuclear factor-kappa B is differentially regulated in human monocytic cellsQ41020142
PARP-1: Friend or Foe of DNA Damage and Repair in Tumorigenesis?Q42107975
Activation of HIV-1 LTR by Rad51 in microglial cellsQ42182598
Attenuation of neointima formation through the inhibition of DNA repair enzyme PARP-1 in balloon-injured rat carotid arteryQ44814390
Contribution of poly(ADP-ribose) polymerase to postischemic blood-brain barrier damage in ratsQ48314697
HIV-1 Tat protein is poly(ADP-ribosyl)ated in vitroQ77998845
PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severityQ83461986
The parp-1 inhibitor ino-1001 facilitates hemodynamic stabilization without affecting DNA repair in porcine thoracic aortic cross-clamping-induced ischemia/reperfusionQ83834120
HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled ReceptorQ22242268
How HIV takes advantage of the cytoskeleton in entry and replicationQ27021639
Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditionsQ27321704
Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cellsQ28270680
Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinaseQ29614246
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brainQ29618472
PARP inhibition: PARP1 and beyondQ29619617
HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interactionQ30010274
Effect of acute poly(ADP-ribose) polymerase inhibition by 3-AB on blood-brain barrier permeability and edema formation after focal traumatic brain injury in rats.Q33551352
Role of CXCR4 in cell-cell fusion and infection of monocyte-derived macrophages by primary human immunodeficiency virus type 1 (HIV-1) strains: two distinct mechanisms of HIV-1 dual tropism.Q33648601
Morphine enhances HIV infection of human blood mononuclear phagocytes through modulation of beta-chemokines and CCR5 receptorQ33683180
HIV-1 neuroimmunity in the era of antiretroviral therapy.Q33733529
Brain cell reservoirs of latent virus in presymptomatic HIV-infected individualsQ34003966
Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulationQ34023297
A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Delta32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4.Q34333673
Chemokines in cerebrospinal fluid correlate with cerebral metabolite patterns in HIV-infected individualsQ34544836
Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integrationQ34730830
The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disordersQ35003250
PARP goes transcriptionQ35155777
Viral exploitation of actin: force-generation and scaffolding functions in viral infectionQ35216851
NF-κB signaling mediates acquired resistance after PARP inhibitionQ35551882
Modulation of HIV-1 replication by a novel RhoA effector activityQ35619856
Cannabinoid receptor 2-mediated attenuation of CXCR4-tropic HIV infection in primary CD4+ T cellsQ35842577
Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration of HIV-1 infected monocytesQ36062880
The trinity of the cortical actin in the initiation of HIV-1 infectionQ36156531
Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells.Q36559702
Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonistsQ36775401
Mechanisms of neuroimmunity and neurodegeneration associated with HIV-1 infection and AIDS.Q37015360
P304page(s)878
P577publication date2015-08-25
P1433published inFrontiers in MicrobiologyQ27723481
P1476titleThe dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity
P478volume6

Reverse relations

cites work (P2860)
Q90512417Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide
Q91639383Human immunodeficiency virus type 1 transcription is regulated by thieno[3,4- d ]pyrimidine
Q27303034PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier
Q59137850Structure-based mechanism of action of a viral poly(ADP-ribose) polymerase 1-interacting protein facilitating virus replication
Q89291574The PARP1-Siah1 Axis Controls HIV-1 Transcription and Expression of Siah1 Substrates

Search more.