Glutamate carboxypeptidase II gene knockout attenuates oxidative stress and cortical apoptosis after traumatic brain injury

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Glutamate carboxypeptidase II gene knockout attenuates oxidative stress and cortical apoptosis after traumatic brain injury is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1028543016
P356DOI10.1186/S12868-016-0251-1
P8608Fatcat IDrelease_mbqyy2bpzbegzpmyr2jnjlchiu
P932PMC publication ID4836105
P698PubMed publication ID27091009

P2093author name stringYang Gao
Yong Wang
Yang Cao
Joseph H Neale
Jiyao Jiang
Xingguang Luo
Qizhong Luo
Yingying Lin
Chunlong Zhong
Siyi Xu
Jingang Bao
P2860cites workBench-to-bedside review: Apoptosis/programmed cell death triggered by traumatic brain injuryQ24802137
N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous systemQ28141091
The Bcl2 family: regulators of the cellular life-or-death switchQ29614982
NAAG peptidase inhibition in the periaqueductal gray and rostral ventromedial medulla reduces flinching in the formalin model of inflammationQ30459203
Advances in understanding the peptide neurotransmitter NAAG and appearance of a new member of the NAAG neuropeptide familyQ30465259
Edema and brain traumaQ30976996
GCP II (NAALADase) inhibition suppresses mossy fiber-CA3 synaptic neurotransmission by a presynaptic mechanismQ33606875
Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenalQ33790988
Reduced cAMP, Akt activation and p65-c-Rel dimerization: mechanisms involved in the protective effects of mGluR3 agonists in cultured astrocytesQ33968317
Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteinsQ34202874
Glutamate neurotoxicity, oxidative stress and mitochondria.Q34263800
Salidroside improves behavioral and histological outcomes and reduces apoptosis via PI3K/Akt signaling after experimental traumatic brain injuryQ34430013
Oxidative glutamate toxicity involves mitochondrial dysfunction and perturbation of intracellular Ca2+ homeostasisQ34510183
Activation of Group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptakeQ34534415
Glutamate neurotoxicity and diseases of the nervous systemQ34560997
Effects of N-acetylaspartylglutamate (NAAG) peptidase inhibition on release of glutamate and dopamine in prefrontal cortex and nucleus accumbens in phencyclidine model of schizophreniaQ36052391
Blockade of N-acetylaspartylglutamate peptidases: a novel protective strategy for brain injuries and neurological disordersQ38185090
Traumatic brain injury and mitochondrial dysfunctionQ38530295
N-acetylaspartylglutamate is an agonist at mGluR₃ in vivo and in vitroQ38833017
Role of N-methyl-D-aspartate receptors in polychlorinated biphenyl mediated neurotoxicityQ39913970
Enhancement of glutamate uptake mediates the neuroprotection exerted by activating group II or III metabotropic glutamate receptors on astrocytes.Q40462883
Biochemical changes associated with selective neuronal death following short-term cerebral ischaemia.Q40480209
Mice lacking glutamate carboxypeptidase II develop normally, but are less susceptible to traumatic brain injuryQ41074666
Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways.Q43694465
NAAG peptidase inhibitor reduces acute neuronal degeneration and astrocyte damage following lateral fluid percussion TBI in ratsQ45270189
NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat.Q46142561
Neuroprotective effects of nicotinamide and 1-methylnicotinamide in acute excitotoxicity in vitro.Q46680679
Cytochrome c release and caspase activation after traumatic brain injury.Q48493064
Neuroprotective effects of osthole pretreatment against traumatic brain injury in ratsQ48792453
Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cellsQ48856939
Mitochondrial regulation of apoptotic cell death.Q53620895
Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stressQ69378856
Metabotropic glutamate receptor 3 protects neurons from glucose-induced oxidative injury by increasing intracellular glutathione concentrationQ80085089
P921main subjecttraumatic brain injuryQ1995526
traumatic stressQ16920843
P304page(s)15
P577publication date2016-04-18
P1433published inBMC NeuroscienceQ15766477
P1476titleGlutamate carboxypeptidase II gene knockout attenuates oxidative stress and cortical apoptosis after traumatic brain injury
P478volume17

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cites work (P2860)
Q38887993A role for the locus coeruleus in the analgesic efficacy of N-acetylaspartylglutamate peptidase (GCPII) inhibitors ZJ43 and 2-PMPA.
Q36118961Astaxanthin alleviates cerebral edema by modulating NKCC1 and AQP4 expression after traumatic brain injury in mice.
Q48171011Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its γ-Substituted Ester Prodrugs
Q55467314Inhibition of endoplasmic reticulum stress alleviates secondary injury after traumatic brain injury.
Q64883818Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice.
Q59336481Metabolite differences between glutamate carboxypeptidase II gene knockout mice and their wild-type littermates after traumatic brain injury: a 7-tesla H-MRS study
Q60308381N-acetylcysteine amide provides neuroprotection via Nrf2-ARE pathway in a mouse model of traumatic brain injury
Q38912835NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer's, and Ethanol Intoxication.
Q92021977Polydatin prevents the induction of secondary brain injury after traumatic brain injury by protecting neuronal mitochondria
Q41960021Severity of experimental traumatic brain injury modulates changes in concentrations of cerebral free amino acids
Q89496691The Emerging Role of Sestrin2 in Cell Metabolism, and Cardiovascular and Age-Related Diseases
Q38831232The therapeutic and diagnostic potential of the prostate specific membrane antigen/glutamate carboxypeptidase II (PSMA/GCPII) in cancer and neurological disease
Q47815398Traumatic Brain Injury Impairs Myogenic Constriction of Cerebral Arteries: Role of Mitochondria-Derived H2O2 and TRPV4-Dependent Activation of BKca Channels

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