High-dose tamoxifen as an enhancer of etoposide cytotoxicity. Clinical effects and in vitro assessment in p-glycoprotein expressing cell lines

scientific article

High-dose tamoxifen as an enhancer of etoposide cytotoxicity. Clinical effects and in vitro assessment in p-glycoprotein expressing cell lines is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1046150997
P356DOI10.1038/BJC.1992.369
P932PMC publication ID1977984
P698PubMed publication ID1358168
P5875ResearchGate publication ID21797878

P2093author name stringPhilip P
Carmichael J
Harris AL
Stuart NS
Kirk J
Houlbrook S
Tonkin K
Lien EA
P2860cites workEffect of tamoxifen on cell lines displaying the multidrug-resistant phenotypeQ30909909
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Analysis of P-glycoprotein phosphorylation in HL60 cells isolated for resistance to vincristineQ41690863
Reversal of acquired resistance to adriamycin in CHO cells by tamoxifen and 4-hydroxy tamoxifen: role of drug interaction with alpha 1 acid glycoproteinQ41715788
Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell lineQ41724047
Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells.Q41734532
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Multidrug resistance phenotype of human BRO melanoma cells transfected with a wild-type human mdr1 complementary DNA.Q41740564
P-glycoprotein-independent mechanism of resistance to VP-16 in multidrug-resistant tumor cell lines: pharmacokinetic and photoaffinity labeling studiesQ41881467
Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by tamoxifen and other triparanol analogues.Q42249927
Role of differential drug uptake, efflux, and binding of etoposide in sensitive and resistant human tumor cell lines: implications for the mechanisms of drug resistanceQ44253536
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Effects of the pH dependence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay.Q50886497
Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.Q50904345
Inhibition of protein kinase C mediated signal transduction by tamoxifen. Importance for antitumour activity.Q50906237
Intermittent high-dose tamoxifen as a potential modifier of multidrug resistance.Q54279436
Circumvention of pleiotropic drug resistance in subcutaneous tumours in vivo with verapamil and clomipramineQ54307235
Toremifene: pharmacologic and pharmacokinetic basis of reversing multidrug resistance.Q54346288
Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.Q54356862
Structural features determining activity of phenothiazines and related drugs for inhibition of cell growth and reversal of multidrug resistance.Q54367285
Modulation of induced resistance to adriamycin in two human breast cancer cell lines with tamoxifen or perhexiline maleateQ54390461
Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.Q54419426
Interactions among membrane transport systems: anthracyclines, calcium antagonists and anti-estrogens.Q54424007
Potentiation of vincristine and Adriamycin effects in human hemopoietic tumor cell lines by calcium antagonists and calmodulin inhibitors.Q54497909
Chemotherapy (cyclophosphamide, vincristine, and prednisone) versus radiotherapy (total body irradiation) for stage III-IV poorly differentiated lymphocytic lymphomaQ67026274
Mechanisms of resistance to daunorubicin in Ehrlich ascites tumor cellsQ67325558
Phosphorylation of topoisomerase II by casein kinase II and protein kinase C: effects on enzyme-mediated DNA cleavage/religation and sensitivity to the antineoplastic drugs etoposide and 4'-(9-acridinylamino)methane-sulfon-m-anisidideQ67843573
Factors contributing to adriamycin sensitivity in human xenograft tumors: the relationship between expression of the MDR1, GST-pi and topoisomerase II genes and tumor sensitivity to adriamycinQ67845165
Identification of 4-hydroxy-N-desmethyltamoxifen as a metabolite of tamoxifen in human bileQ68285921
Determination of tamoxifen and four metabolites in serum by low-dispersion liquid chromatographyQ69206808
Distribution of 4-hydroxy-N-desmethyltamoxifen and other tamoxifen metabolites in human biological fluids during tamoxifen treatmentQ69579611
Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamilQ70721995
Studies on the metabolism and pharmacokinetics of tamoxifen in normal volunteersQ71356163
Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase IIQ72397901
Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell LinesQ72561176
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectcytotoxicityQ246181
tamoxifenQ412178
etoposideQ418817
P304page(s)833-839
P577publication date1992-11-01
P1433published inBritish Journal of CancerQ326309
P1476titleHigh-dose tamoxifen as an enhancer of etoposide cytotoxicity. Clinical effects and in vitro assessment in p-glycoprotein expressing cell lines
P478volume66

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cites work (P2860)
Q36976172AMPK Activation and Metabolic Reprogramming by Tamoxifen through Estrogen Receptor-Independent Mechanisms Suggests New Uses for This Therapeutic Modality in Cancer Treatment
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Q43503919Treatment of supratentorial glioblastoma multiforme with radiotherapy and a combination of BCNU and tamoxifen: a phase II study.

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