An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination

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An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination is …
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scholarly articleQ13442814

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P819ADS bibcode2016NatCo...711312K
P356DOI10.1038/NCOMMS11312
P932PMC publication ID4853428
P698PubMed publication ID27115988
P5875ResearchGate publication ID301671080

P50authorV. Wee YongQ56101901
Marcus W KochQ58460928
Khalil S RawjiQ87362635
Jason R PlemelQ39420528
P2093author name stringPing Zhang
Chang-Chun Ling
Michael B Keough
James A Rogers
Tieyu Chen
Erin L Stephenson
Samuel K Jensen
Lorraine W Lau
Mitchel G Hurlbert
P2860cites workInhibition of CNS remyelination by the presence of semaphorin 3A.Q54383932
LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitisQ57186801
Semaphorin 3A and 3F: key players in myelin repair in multiple sclerosis?Q64461677
Astrocytes promote process outgrowth by adult human oligodendrocytes in vitro through interaction between bFGF and astrocyte extracellular matrixQ71612409
Vulnerability of human neurons to T cell-mediated cytotoxicityQ73552887
N-Acetylglucosamine Inhibits T-helper 1 (Th1)/T-helper 17 (Th17) Cell Responses and Treats Experimental Autoimmune EncephalomyelitisQ22248070
Remyelination therapy for multiple sclerosisQ26824246
Regeneration beyond the glial scarQ28239915
Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injuryQ28253162
Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiationQ28290361
Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNSQ28589814
Remyelination protects axons from demyelination-associated axon degenerationQ29302305
Chondroitinase ABC promotes functional recovery after spinal cord injuryQ29615017
Skin-homing receptors on effector leukocytes are differentially sensitive to glyco-metabolic antagonism in allergic contact dermatitisQ33606887
PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regenerationQ33610127
Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2Q33953332
Oligodendroglia metabolically support axons and contribute to neurodegeneration.Q34032818
The inhibitory effects of chondroitin sulfate proteoglycans on oligodendrocytesQ34208617
Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brainQ34341627
A regenerative approach to the treatment of multiple sclerosisQ34376469
Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation.Q34441121
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivoQ34472745
Remyelination can be extensive in multiple sclerosis despite a long disease courseQ34578773
Protocol to isolate a large amount of functional oligodendrocyte precursor cells from the cerebral cortex of adult mice and humansQ35058625
Peracetylated 4-fluoro-glucosamine reduces the content and repertoire of N- and O-glycans without direct incorporation.Q35065252
Experimental demyelination and remyelination of murine spinal cord by focal injection of lysolecithin.Q35461070
Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3.Q36501925
Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis.Q36793938
Rejuvenation of regeneration in the aging central nervous systemQ37023170
Alterations in sulfated chondroitin glycosaminoglycans following controlled cortical impact injury in miceQ37249700
Regulation of heparan sulfate and chondroitin sulfate glycosaminoglycan biosynthesis by 4-fluoro-glucosamine in murine airway smooth muscle cellsQ37285056
Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodelingQ37347920
Enhancing remyelination in disease--can we wrap it up?Q37867334
Combination treatment with chondroitinase ABC in spinal cord injury--breaking the barrierQ38120433
Pathophysiology of the brain extracellular matrix: a new target for remyelination.Q38132334
Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturationQ38362396
Regeneration of CNS axons back to their target following treatment of adult rat brain with chondroitinase ABC.Q38524950
Derivation of enriched oligodendrocyte cultures and oligodendrocyte/neuron myelinating co-cultures from post-natal murine tissues.Q39149972
Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination.Q39266450
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrityQ39492965
Inhibiting glycosaminoglycan chain polymerization decreases the inhibitory activity of astrocyte-derived chondroitin sulfate proteoglycansQ40030617
Remyelination is extensive in a subset of multiple sclerosis patients.Q40295868
Versican V1 isoform induces neuronal differentiation and promotes neurite outgrowthQ40831376
An in vitro model of reactive astrogliosis and its effect on neuronal growth.Q41952761
White matter extracellular matrix chondroitin sulfate/dermatan sulfate proteoglycans in multiple sclerosisQ43838103
Additive effect of the combination of glatiramer acetate and minocycline in a model of MS.Q45180838
Remyelination capacity of the MS brain decreases with disease chronicityQ45353313
Screening for inhibitors of microglia to reduce neuroinflammationQ46213310
Localization of chondroitin sulfate proteoglycan versican in adult brain with special reference to large projection neuronsQ46307798
Overcoming neurite-inhibitory chondroitin sulfate proteoglycans in the astrocyte matrix.Q48098141
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P304page(s)11312
P577publication date2016-04-26
P1433published inNature CommunicationsQ573880
P1476titleAn inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination
P478volume7

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cites work (P2860)
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