Cholesterol Corrects Altered Conformation of MHC-II Protein in Leishmania donovani Infected Macrophages: Implication in Therapy

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Cholesterol Corrects Altered Conformation of MHC-II Protein in Leishmania donovani Infected Macrophages: Implication in Therapy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PNTD.0004710
P932PMC publication ID4877013
P698PubMed publication ID27214205

P2093author name stringSyamal Roy
Saikat Chakrabarti
Koushik Roy
Sapan Mandloi
P2860cites workCanonical dynamics: Equilibrium phase-space distributionsQ21709091
A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic ReceptorQ27650801
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Leishmania donovani infection enhances lateral mobility of macrophage membrane protein which is reversed by liposomal cholesterolQ28542482
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Embedded cholesterol in the nicotinic acetylcholine receptorQ30371845
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Leishmania donovani isolates with antimony-resistant but not -sensitive phenotype inhibit sodium antimony gluconate-induced dendritic cell activationQ33587372
Direct visualization of peptide/MHC complexes at the surface and in the intracellular compartments of cells infected in vivo by Leishmania majorQ33728514
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Turnover of Ia-peptide complexes is facilitated in viable antigen-presenting cells: biosynthetic turnover of Ia vs. peptide exchangeQ33867750
Human visceral leishmaniasis: decrease in serum cholesterol as a function of splenic parasite loadQ33877648
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Immunobiological studies on experimental visceral leishmaniasis. II. Adherent cell-mediated down-regulation of delayed-type hypersensitivity response and up-regulation of B cell activationQ67546042
The assignment of chain specificities for anti-Ia monoclonal antibodies using L cell transfectantsQ68737683
Free ligand-induced dissociation of MHC-antigen complexesQ70147109
Macrophage‐T cell interaction in experimental visceral leishmaniasis: failure to express costimulatory molecules on Leishmania‐infected macrophages and its implication in the suppression of cell‐mediated immunityQ71815137
Infectivity and attenuation of Leishmania donovani promastigotes: association of galactosyl transferase with loss of parasite virulenceQ77337151
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Resistance of Francisella tularensis strains against reactive nitrogen and oxygen species with special reference to the role of KatG.Q35689391
Hyperlipidemia offers protection against Leishmania donovani infection: role of membrane cholesterolQ36387245
Cholesterol and the interaction of proteins with membrane domains.Q36436022
Leishmania donovani targets Dicer1 to downregulate miR-122, lower serum cholesterol, and facilitate murine liver infection.Q36708313
Cholesterol lowering drug may influence cellular immune response by altering MHC II functionQ37222694
A molecular basis for the Ia.2 and Ia.19 antigenic determinantsQ37686652
Cholesterol modulates the dimer interface of the β₂-adrenergic receptor via cholesterol occupancy sitesQ37700209
Cholesterol-protein interaction: methods and cholesterol reporter moleculesQ37705126
Cholesterol-binding viral proteins in virus entry and morphogenesisQ37705129
Modulation of the cell-mediated immune response in kala-azar and post-kala-azar dermal leishmaniasis in relation to chemotherapy.Q39299374
Fluidity parameters of lipid regions determined by fluorescence polarizationQ39781931
Leishmania donovani affects antigen presentation of macrophage by disrupting lipid raftsQ40382223
Why is low blood cholesterol associated with risk of nonatherosclerotic disease death?Q40821894
The Ia.2 epitope defines a subset of lipid raft-resident MHC class II molecules crucial to effective antigen presentation.Q41170133
The effect of membrane cholesterol content on ion transport processes in plasma membranesQ41387625
Role of transmembrane domain interactions in the assembly of class II MHC moleculesQ41598205
Peptide binding to active class II MHC protein on the cell surfaceQ41919691
Class II MHC/peptide interaction in Leishmania donovani infection: implications in vaccine designQ42214354
IL-12 induces IFN-gamma expression and secretion in mouse peritoneal macrophages.Q42445043
Cytoplasmic domain of human myelin protein zero likely folded as beta-structure in compact myelin.Q42957974
Designing therapies against experimental visceral leishmaniasis by modulating the membrane fluidity of antigen-presenting cellsQ43121720
Identification of cholesterol binding sites in the serotonin1A receptor.Q43776361
Molecular modeling of the human serotonin(1A) receptor: role of membrane cholesterol in ligand binding of the receptorQ44157553
Regulation of platelet-activating factor synthesis in human monocytes by dipalmitoyl phosphatidylcholineQ44495396
Differences in the onset of the inflammatory response to cutaneous leishmaniasis in resistant and susceptible miceQ45070476
A cholesterol-rich diet accelerates bacteriologic sterilization in pulmonary tuberculosisQ45261443
Measurement of peptide dissociation from MHC class II moleculesQ46629980
Difference in microviscosity induced by different cholesterol levels in the surface membrane lipid layer of normal lymphocytes and malignant lymphoma cellsQ47843173
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectLeishmania donovaniQ1950752
P304page(s)e0004710
P577publication date2016-05-23
P1433published inPLoS Neglected Tropical DiseasesQ3359737
P1476titleCholesterol Corrects Altered Conformation of MHC-II Protein in Leishmania donovani Infected Macrophages: Implication in Therapy
P478volume10

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cites work (P2860)
Q93054243Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation
Q49866040Cholesterol-lowering drug, in combination with chromium chloride, induces early apoptotic signals in intracellular L. donovani amastigotes, leading to death
Q90665965Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis
Q55043523Leishmania Hijacks Myeloid Cells for Immune Escape.
Q58600968Leishmania donovani reduces the levels of retinoic acid-synthesizing enzymes in infected macrophages and favoring its own survival
Q90682443Structure, Topology, and Dynamics of Membrane-Inserted Polypeptides and Lipids by Solid-State NMR Spectroscopy: Investigations of the Transmembrane Domains of the DQ Beta-1 Subunit of the MHC II Receptor and of the COP I Protein p24

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