SUMO-Modification of the La Protein Facilitates Binding to mRNA In Vitro and in Cells

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SUMO-Modification of the La Protein Facilitates Binding to mRNA In Vitro and in Cells is …
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scholarly articleQ13442814

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P819ADS bibcode2016PLoSO..1156365K
P356DOI10.1371/JOURNAL.PONE.0156365
P8608Fatcat IDrelease_o5hssphi65dndh52t2ovqrkv4m
P932PMC publication ID4880191
P698PubMed publication ID27224031

P50authorJeffery L TwissQ87012683
Tilman HeiseQ89494526
Erna A van NiekerkQ114073100
Pierre ThibaultQ55723013
P2093author name stringGunhild Sommer
Venkatesh Kota
Chantal Durette
P2860cites workShuttling of the autoantigen La between nucleus and cell surface after uv irradiation of human keratinocytesQ68630616
Purification and characterization of the Ro and La antigens. Modulation of their binding affinities to poly(U) by phosphorylation and the presence of ATPQ69636718
The RNA-binding protein La contributes to cell proliferation and CCND1 expressionQ85057853
La protein has a positive effect on the translation of TOP mRNAs in vivoQ39542983
Transcription efficiency of human polymerase III genes in vitro does not depend on the RNP-forming autoantigen La.Q39584649
Akt phosphorylation of La regulates specific mRNA translation in glial progenitorsQ39932300
BCR/ABL activates mdm2 mRNA translation via the La antigenQ40666171
Analysis of the intracellular localization and assembly of Ro ribonucleoprotein particles by microinjection into Xenopus laevis oocytesQ41882450
SUMO-1 modification alters ADAR1 editing activityQ41981980
PDGF enhances IRES-mediated translation of Laminin B1 by cytoplasmic accumulation of La during epithelial to mesenchymal transition.Q42213394
All translation elongation factors and the e, f, and h subunits of translation initiation factor 3 are encoded by 5'-terminal oligopyrimidine (TOP) mRNAsQ42418718
Sumoylation modulates the assembly and activity of the pre-mRNA 3' processing complexQ42823824
La gets its wingsQ47868986
Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1Q22009137
Sumoylation of eIF4E activates mRNA translationQ24302311
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA bindingQ24311663
SUMO-1 modification activates the transcriptional response of p53Q24529948
Functional characterization of the X-linked inhibitor of apoptosis (XIAP) internal ribosome entry site element: role of La autoantigen in XIAP translationQ24554132
CK2 is responsible for phosphorylation of human La protein serine-366 and can modulate rpL37 5'-terminal oligopyrimidine mRNA metabolismQ24563432
La enhances IRES-mediated translation of laminin B1 during malignant epithelial to mesenchymal transitionQ24618219
La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNAQ24645620
SUMOylation-Mediated Regulation of Cell Cycle Progression and CancerQ26776081
Roles for SUMO in pre-mRNA processingQ26777328
The La antigen binds 5' noncoding region of the hepatitis C virus RNA in the context of the initiator AUG codon and stimulates internal ribosome entry site-mediated translationQ27481261
System-wide changes to SUMO modifications in response to heat shockQ27865236
The nucleoporin RanBP2 has SUMO1 E3 ligase activityQ28115025
Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selectionQ28119055
The La proteinQ28202309
Aberrant nuclear trafficking of La protein leads to disordered processing of associated precursor tRNAsQ28202636
Preferential modification of nuclear proteins by a novel ubiquitin-like moleculeQ28238897
SUMO: a history of modificationQ28243325
Ubch9 conjugates SUMO but not ubiquitinQ28257546
La autoantigen suppresses IRES-dependent translation of the hepatitis A virusQ28269083
Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigenQ28289437
Phosphorylation of the human La antigen on serine 366 can regulate recycling of RNA polymerase III transcription complexesQ28304944
SUMOylation of the corepressor N-CoR modulates its capacity to repress transcription.Q28589693
SUMO modification of heterogeneous nuclear ribonucleoproteinsQ28611538
The nuclear dot protein sp100, characterization of domains necessary for dimerization, subcellular localization, and modification by small ubiquitin-like modifiersQ28616490
SUMO and transcriptional regulationQ28647169
Conserved and divergent features of the structure and function of La and La-related proteins (LARPs)Q28752425
Protein modification by SUMOQ29547919
La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysateQ29619024
Epstein-Barr virus noncoding RNAs are confined to the nucleus, whereas their partner, the human La protein, undergoes nucleocytoplasmic shuttlingQ30444219
Extracellular stimuli specifically regulate localized levels of individual neuronal mRNAs.Q30480550
Novel CNBP- and La-based translation control systems for mammalian cellsQ30870388
Uncovering global SUMOylation signaling networks in a site-specific mannerQ34041994
Implication of RNA-binding protein La in proliferation, migration and invasion of lymph node-metastasized hypopharyngeal SCC cellsQ34053287
Synthesis of the translational apparatus is regulated at the translational levelQ34058830
Binding of the La autoantigen to the 5' untranslated region of a chimeric human translation elongation factor 1A reporter mRNA inhibits translation in vitroQ34100177
Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA.Q34310515
Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysisQ34513152
An intrinsically disordered C terminus allows the La protein to assist the biogenesis of diverse noncoding RNA precursorsQ34533704
Targeted identification of SUMOylation sites in human proteins using affinity enrichment and paralog-specific reporter ionsQ34763943
Novel RNA chaperone domain of RNA-binding protein La is regulated by AKT phosphorylationQ34883541
A novel post-translational modification of nucleolin, SUMOylation at Lys-294, mediates arsenite-induced cell death by regulating gadd45α mRNA stabilityQ35103925
Body language: the function of PML nuclear bodies in apoptosis regulationQ35204844
Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La proteinQ35740594
System-wide identification of wild-type SUMO-2 conjugation sitesQ35814214
Sumoylation in axons triggers retrograde transport of the RNA-binding protein La.Q35921738
Sumoylation regulates multiple aspects of mammalian poly(A) polymerase functionQ36453553
A frame shift mutation in a hot spot region of the nuclear autoantigen La (SS-B).Q36855718
The La protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2.Q37301910
Nonphosphorylated human La antigen interacts with nucleolin at nucleolar sites involved in rRNA biogenesisQ37684098
Sumoylation of the THO complex regulates the biogenesis of a subset of mRNPs.Q37734386
SUMO modification of Sam68 enhances its ability to repress cyclin D1 expression and inhibits its ability to induce apoptosisQ38314714
Functional characterization of the interaction between human La and hepatitis B virus RNA.Q38337963
La protein is associated with terminal oligopyrimidine mRNAs in actively translating polysomesQ38352983
Molecular characterization of the human La protein.hepatitis B virus RNA.B interaction in vitro.Q38364165
Sumo and the cellular stress responseQ38535130
Analysis of changes in SUMO-2/3 modification during breast cancer progression and metastasisQ38970618
Proteome-wide identification of SUMO2 modification sitesQ39201092
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageQuantQ112270642
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)e0156365
P577publication date2016-05-25
P1433published inPLOS OneQ564954
P1476titleSUMO-Modification of the La Protein Facilitates Binding to mRNA In Vitro and in Cells
P478volume11

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cites work (P2860)
Q36307411Applying a high-throughput fluorescence polarization assay for the discovery of chemical probes blocking La:RNA interactions in vitro and in cells.
Q47586959SUMO Modification of the RNA-Binding Protein La Regulates Cell Proliferation and STAT3 Protein Stability.
Q47367492Sumoylation of the Plant Clock Transcription Factor CCA1 Suppresses DNA Binding
Q47985263The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives.

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