The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver

scientific article

The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SJ.BJP.0706830
P932PMC publication ID2014277
P698PubMed publication ID16894351
P5875ResearchGate publication ID6893437

P2093author name stringY Altschuler
H S White
J G Lamb
B Yagen
M Bialer
E Fibach
S Eyal
M Smith-Yockman
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Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogenQ29616224
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Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sitesQ33832954
Pharmacokinetic-pharmacodynamic relationships of (2S,3S)-valnoctamide and its stereoisomer (2R,3S)-valnoctamide in rodent models of epilepsyQ34226515
Rational development of histone deacetylase inhibitors as anticancer agents: a reviewQ34426444
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutantsQ34488592
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MDR1, chemotherapy and chromatin remodeling.Q35869829
Evolving anticancer drug valproic acid: insights into the mechanism and clinical studies.Q36002354
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Depsipeptide-resistant KU812 cells show reversible P-glycoprotein expression, hyper-acetylated histones, and modulated gene expression profileQ40356263
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Antileukemia activity of the combination of 5-aza-2'-deoxycytidine with valproic acidQ40415058
Histone deacetylases inhibition and tumor cells cytotoxicity by CNS-active VPA constitutional isomers and derivativesQ40429957
Chemoresistance to depsipeptide FK228 [(E)-(1S,4S,10S,21R)-7-[(Z)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] is mediated by reversible MDR1 induction in human cancer cell linesQ40434292
Efflux of depsipeptide FK228 (FR901228, NSC-630176) is mediated by P-glycoprotein and multidrug resistance-associated protein 1.Q40474222
T-cell lymphoma as a model for the use of histone deacetylase inhibitors in cancer therapy: impact of depsipeptide on molecular markers, therapeutic targets, and mechanisms of resistanceQ40583269
Comparison of detoxification enzyme mRNAs in woodrats (Neotoma lepida) and laboratory ratsQ40697918
Can we develop improved derivatives of valproic acid?Q40739202
Glutathione S-transferases and P-glycoprotein in normal rat hepatocytes and hepatoma cells: analysis using flow cytometryQ41442316
Further branching of valproate-related carboxylic acids reduces the teratogenic activity, but not the anticonvulsant effectQ42553750
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Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease MiceQ44619618
Histone deacetylase is a target of valproic acid-mediated cellular differentiationQ44761814
Correlation analysis between anticonvulsant ED50 values of antiepileptic drugs in mice and rats and their therapeutic doses and plasma levelsQ45176492
Modulation of the expression of a multidrug resistance gene (mdr-1/P-glycoprotein) by differentiating agents.Q45825109
CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in miceQ46573657
Valproic acid and all-trans retinoic acid for the treatment of elderly patients with acute myeloid leukemiaQ46582778
Pharmacokinetics and metabolism of a new potent antiepileptic drug, 2,2,3,3-tetramethycyclopropanecarbonylurea, in ratsQ46613328
Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers.Q50900871
On the inhibitory action of mersalyl on microsomal drug oxidation: a rigid organization of the electron transport chain.Q51682719
Variable effects of sodium butyrate on the expression and function of the MDR1 (P-glycoprotein) gene in colon carcinoma cell lines.Q54231075
The enantiomers of the valproic acid analogue 2-n-propyl-4-pentynoic acid (4-yn-VPA): asymmetric synthesis and highly stereoselective teratogenicity in miceQ67583915
Disposition of valpromide, valproic acid, and valnoctamide in the brain, liver, plasma, and urine of ratsQ71302790
Lack of correlation between expression and function of P-glycoprotein in acute myeloid leukemia cell linesQ72285466
Valnoctamide, valpromide and valnoctic acid are much less teratogenic in mice than valproic acidQ74463323
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)250-260
P577publication date2006-08-07
P1433published inBritish Journal of PharmacologyQ919631
P1476titleThe antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver
P478volume149

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