The α2 helix in the DNA ligase IV BRCT-1 domain is required for targeted degradation of ligase IV during adenovirus infection

scientific article published on April 24, 2012

The α2 helix in the DNA ligase IV BRCT-1 domain is required for targeted degradation of ligase IV during adenovirus infection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VIROL.2012.03.006
P8608Fatcat IDrelease_ufp4gjhyurctjguradtfts7dpu
P953full work available at URLhttps://api.elsevier.com/content/article/PII:S0042682212001638?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0042682212001638?httpAccept=text/xml
https://doi.org/10.1016/j.virol.2012.03.006
https://europepmc.org/articles/PMC3382995
https://europepmc.org/articles/PMC3382995?pdf=render
P932PMC publication ID3382995
P698PubMed publication ID22534089
P5875ResearchGate publication ID224848812

P50authorLeslyn A HanakahiQ116547626
P2093author name stringAlessandro Vindigni
Timra Gilson
Gary Ketner
Amy E. Greer
P2860cites workGenome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signalingQ21144354
Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinaseQ24296672
The BRCT Domain Is a Phospho-Protein Binding DomainQ24298428
Termination of NF-kappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligaseQ24309461
Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cellsQ24320116
Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IVQ24323238
A DNA‐Topoisomerase‐11–Binding Protein with Eight Repeating Regions Similar to DNA‐repair Enzymes and to a Cell‐Cycle RegulatorQ24336403
Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machineryQ24538586
Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4Q24644339
The Pfam protein families databaseQ24644670
Two DNA-binding and nick recognition modules in human DNA ligase IIIQ24646413
Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligaseQ37453413
Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53.Q37574153
MRN and the race to the breakQ37622790
Cells from an immunodeficient patient (46BR) with a defect in DNA ligation are hypomutable but hypersensitive to the induction of sister chromatid exchangesQ37683116
Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins.Q38332683
Temporal regulation of the Mre11-Rad50-Nbs1 complex during adenovirus infectionQ39879570
Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1.Q39911661
Distinct requirements of adenovirus E1b55K protein for degradation of cellular substratesQ39963290
Adenovirus E4 34k and E1b 55k oncoproteins target host DNA ligase IV for proteasomal degradationQ40140948
The adenovirus E4orf6 E3 ubiquitin ligase complex assembles in a novel fashionQ40157700
Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK.Q40180343
Estrogen-dependent growth and estrogen receptor (ER)-alpha concentration in T47D breast cancer cells are inhibited by VACM-1, a cul 5 geneQ40190998
Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complexQ40717443
Characterization of the 55K adenovirus type 5 E1B product and related proteinsQ41475587
The Adenovirus E1b55K/E4orf6 Complex Induces Degradation of the Bloom Helicase during InfectionQ42583162
Context of multiubiquitin chain attachment influences the rate of Sic1 degradationQ44487504
A monoclonal antibody detecting the adenovirus type 5-E1b-58Kd tumor antigen: characterization of the E1b-58Kd tumor antigen in adenovirus-infected and -transformed cellsQ44637858
DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domainsQ46835609
Preferred in vivo ubiquitination sitesQ50771337
Ubiquitination of the PEST-like endocytosis signal of the yeast a-factor receptorQ73538505
Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugationQ124796412
Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombinationQ24652220
Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical developmentQ24672124
Solution Structure and Backbone Dynamics of the Human DNA Ligase IIIα BRCT Domain,Q27635740
Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1Q27664093
RING domain E3 ubiquitin ligasesQ27860546
Isolation of monoclonal antibodies specific for human c-myc proto-oncogene productQ27860841
Yeast DNA ligase IV mediates non-homologous DNA end joiningQ27931843
Function and regulation of cullin-RING ubiquitin ligasesQ28131707
Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF ComplexQ28210666
Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancerQ28260830
Human DNA ligase I completely encircles and partially unwinds nicked DNAQ28295280
Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme chargingQ28307753
The Jpred 3 secondary structure prediction serverQ29547592
Characteristics of a human cell line transformed by DNA from human adenovirus type 5Q29547863
Physiological functions of the HECT family of ubiquitin ligasesQ29617293
EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressorsQ33261811
The ubiquitination code: a signalling problemQ33343831
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complexQ33489621
Analysis of synthesis, stability, phosphorylation, and interacting polypeptides of the 34-kilodalton product of open reading frame 6 of the early region 4 protein of human adenovirus type 5Q33641023
Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradationQ33982295
Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugationQ34055195
The ubiquitin system: from basic mechanisms to the patient bed.Q34330613
Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agentsQ34409945
Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific mannerQ34654453
Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells.Q35883364
p53: traffic cop at the crossroads of DNA repair and recombinationQ36028209
Structural basis for phosphorylation-dependent signaling in the DNA-damage responseQ36333360
Packaging capacity and stability of human adenovirus type 5 vectors.Q36653293
Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigenQ36774702
Redundant control of adenovirus late gene expression by early region 4Q36780621
BRCT domains: phosphopeptide binding and signaling modulesQ37175603
Identification of integrin alpha3 as a new substrate of the adenovirus E4orf6/E1B 55-kilodalton E3 ubiquitin ligase complexQ37191952
E1B 55k-independent dissociation of the DNA ligase IV/XRCC4 complex by E4 34k during adenovirus infectionQ37210181
Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylationQ37424165
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectAdenoviridaeQ193447
P304page(s)128-135
P577publication date2012-04-24
P1433published inVirologyQ7934867
P1476titleThe α2 helix in the DNA ligase IV BRCT-1 domain is required for targeted degradation of ligase IV during adenovirus infection
P478volume428

Reverse relations

cites work (P2860)
Q38854475Analysis of the Cullin binding sites of the E4orf6 proteins of human adenovirus E3 ubiquitin ligases.
Q35007981Yeast DNA ligase IV mutations reveal a nonhomologous end joining function of BRCT1 distinct from XRCC4/Lif1 binding

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