| P50 | author | Gabriela Chiosis | Q29515233 |
| P2093 | author name string | Jeffrey L Brodsky | |
| | Hardik J Patel | |
| | Patrick G Needham | |
| | Patrick H Thibodeau | |
| P2860 | cites work | Multiple roles of prolyl residues in structure and folding | Q74247254 |
| | CFTR expression and ER-associated degradation in yeast | Q77830989 |
| | Allosteric regulation of Hsp70 chaperones involves a conserved interdomain linker | Q79278307 |
| | Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate | Q21090602 |
| | Hsp70 chaperones: cellular functions and molecular mechanism | Q24644472 |
| | The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system | Q24676115 |
| | Structural insights into substrate binding by the molecular chaperone DnaK | Q27621983 |
| | Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP | Q27678317 |
| | Functional analysis of Hsp70 inhibitors | Q27680671 |
| | Structure and dynamics of the ATP-bound open conformation of Hsp70 chaperones | Q27683212 |
| | Threonine 204 of the chaperone protein Hsc70 influences the structure of the active site, but is not essential for ATP hydrolysis | Q27731445 |
| | Structural analysis of substrate binding by the molecular chaperone DnaK | Q27732810 |
| | Dissecting the ER-associated degradation of a misfolded polytopic membrane protein | Q27930024 |
| | Previously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation | Q27930173 |
| | Nucleotide exchange factor for the yeast Hsp70 molecular chaperone Ssa1p | Q27931293 |
| | Role of Hsp70 subfamily, Ssa, in protein folding in yeast cells, seen in luciferase-transformed ssa mutants | Q27931476 |
| | The yeast Hsp110, Sse1p, exhibits high-affinity peptide binding | Q27932962 |
| | Complex interactions among members of an essential subfamily of hsp70 genes in Saccharomyces cerevisiae | Q27933205 |
| | Differential regulation of Hsp70 subfamilies by the eukaryotic DnaJ homologue YDJ1. | Q27933284 |
| | Prion-impairing mutations in Hsp70 chaperone Ssa1: effects on ATPase and chaperone activities | Q27934126 |
| | Regulation of Hsp70 function by a eukaryotic DnaJ homolog | Q27934505 |
| | Distinct roles for the Hsp40 and Hsp90 molecular chaperones during cystic fibrosis transmembrane conductance regulator degradation in yeast | Q27934755 |
| | The dissociation of ATP from hsp70 of Saccharomyces cerevisiae is stimulated by both Ydj1p and peptide substrates | Q27935038 |
| | The yeast hsp70 homologue Ssa is required for translation and interacts with Sis1 and Pab1 on translating ribosomes | Q27935337 |
| | Functional interaction of cytosolic hsp70 and a DnaJ-related protein, Ydj1p, in protein translocation in vivo | Q27935347 |
| | Folding in vivo of a newly translated yeast cytosolic enzyme is mediated by the SSA class of cytosolic yeast Hsp70 proteins | Q27935523 |
| | Mitochondrial Hsp70 Ssc1: role in protein folding. | Q27936101 |
| | Differential requirement for the mitochondrial Hsp70-Tim44 complex in unfolding and translocation of preproteins. | Q27936192 |
| | YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism | Q27937736 |
| | Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein | Q27938024 |
| | Chaperone network in the yeast cytosol: Hsp110 is revealed as an Hsp70 nucleotide exchange factor | Q27940000 |
| | Coordination of translational control and protein homeostasis during severe heat stress | Q27940089 |
| | The heat shock protein Ssa2p is required for import of fructose-1, 6-bisphosphatase into Vid vesicles | Q27940343 |
| | Adapting proteostasis for disease intervention | Q28131818 |
| | HspBP1, a homologue of the yeast Fes1 and Sls1 proteins, is an Hsc70 nucleotide exchange factor | Q28213524 |
| | Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocket | Q28246523 |
| | Allostery in the Hsp70 chaperone proteins | Q28266387 |
| | The Hsp70 and Hsp60 chaperone machines | Q29547601 |
| | The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability | Q29547634 |
| | Protein quality control in neurodegenerative disease | Q38000623 |
| | Hsp70 chaperone dynamics and molecular mechanism | Q38135145 |
| | Hsp70 in cancer: back to the future | Q38263003 |
| | GrpE, Hsp110/Grp170, HspBP1/Sil1 and BAG domain proteins: nucleotide exchange factors for Hsp70 molecular chaperones | Q38285291 |
| | A bipartite signaling mechanism involved in DnaJ-mediated activation of the Escherichia coli DnaK protein | Q38357902 |
| | Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein | Q38735132 |
| | Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer | Q40113117 |
| | Interaction of heavy chain binding protein (BiP/GRP78) with adenine nucleotides | Q40817891 |
| | Mutations in the substrate binding domain of the Escherichia coli 70 kDa molecular chaperone, DnaK, which alter substrate affinity or interdomain coupling | Q40972262 |
| | Structural basis of interdomain communication in the Hsc70 chaperone. | Q41072966 |
| | Real-time observation of the conformational dynamics of mitochondrial Hsp70 by spFRET. | Q41460745 |
| | Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions. | Q41791610 |
| | An interdomain energetic tug-of-war creates the allosterically active state in Hsp70 molecular chaperones | Q41959252 |
| | Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation | Q42264565 |
| | Cytoplasmic Hsp70 promotes ubiquitination for endoplasmic reticulum-associated degradation of a misfolded mutant of the yeast plasma membrane ATPase, PMA1. | Q42515885 |
| | Sequence-specific rates of interaction of target peptides with the molecular chaperones DnaK and DnaJ. | Q42687566 |
| | The Hsp70 chaperone Ssa1 is essential for catabolite induced degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase | Q43049904 |
| | Destabilization of peptide binding and interdomain communication by an E543K mutation in the bovine 70-kDa heat shock cognate protein, a molecular chaperone. | Q43997162 |
| | Allosteric regulation of Hsp70 chaperones by a proline switch | Q46925402 |
| | Characterization of nucleotide-free uncoating ATPase and its binding to ATP, ADP, and ATP analogues | Q48164278 |
| | Disassembling protein aggregates in the yeast cytosol. The cooperation of Hsp26 with Ssa1 and Hsp104. | Q50770803 |
| | Thermodynamic and structural analysis of the folding/unfolding transitions of the Escherichia coli molecular chaperone DnaK. | Q52514099 |
| | The ATPase core of a clathrin uncoating protein | Q70161623 |
| | Nucleotide-induced conformational changes in the ATPase and substrate binding domains of the DnaK chaperone provide evidence for interdomain communication | Q71921283 |
| | Molecular chaperones in protein folding and proteostasis | Q29547715 |
| | Thermofluor-based high-throughput stability optimization of proteins for structural studies | Q29614747 |
| | The HSP70 chaperone machinery: J proteins as drivers of functional specificity | Q29616140 |
| | Molecular chaperones and protein quality control | Q29617795 |
| | Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins | Q29620285 |
| | Conformational properties of bacterial DnaK and yeast mitochondrial Hsp70. Role of the divergent C-terminal alpha-helical subdomain. | Q30350874 |
| | A modified HSP70 inhibitor shows broad activity as an anticancer agent | Q30537961 |
| | In vivo bipartite interaction between the Hsp40 Sis1 and Hsp70 in Saccharomyces cerevisiae | Q31145668 |
| | Interaction of the Hsp70 molecular chaperone, DnaK, with its cochaperone DnaJ. | Q33574540 |
| | Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40. | Q33580742 |
| | Expression of a malarial Hsp70 improves defects in chaperone-dependent activities in ssa1 mutant yeast | Q33916442 |
| | Heat shock protein 70 (hsp70) as an emerging drug target. | Q33956906 |
| | Protein-misfolding diseases and chaperone-based therapeutic approaches | Q34524526 |
| | Mutation of the ATP-binding pocket of SSA1 indicates that a functional interaction between Ssa1p and Ydj1p is required for post-translational translocation into the yeast endoplasmic reticulum. | Q34610710 |
| | Degradation of unassembled Vph1p reveals novel aspects of the yeast ER quality control system | Q34663301 |
| | Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70. | Q34747269 |
| | A yeast homologue of Hsp70, Ssa1p, regulates turnover of the MFA2 transcript through its AU-rich 3' untranslated region | Q34889289 |
| | HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells | Q35118904 |
| | The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma. | Q35138259 |
| | Single methyl group determines prion propagation and protein degradation activities of yeast heat shock protein (Hsp)-70 chaperones Ssa1p and Ssa2p | Q35170861 |
| | Intragenic suppressors of Hsp70 mutants: interplay between the ATPase- and peptide-binding domains | Q35601345 |
| | Mechanism of substrate recognition by Hsp70 chaperones. | Q35843735 |
| | Hsp70 chaperone ligands control domain association via an allosteric mechanism mediated by the interdomain linker | Q35847276 |
| | A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins | Q36233355 |
| | Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP. | Q36236461 |
| | Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast | Q36280501 |
| | Mechanism of regulation of hsp70 chaperones by DnaJ cochaperones | Q36351463 |
| | Hsp70 molecular chaperones: emerging roles in human disease and identification of small molecule modulators | Q36536342 |
| | Design of a fluorescence polarization assay platform for the study of human Hsp70 | Q36881788 |
| | Ste6p mutants defective in exit from the endoplasmic reticulum (ER) reveal aspects of an ER quality control pathway in Saccharomyces cerevisiae | Q36912883 |
| | Multiple hsp70 isoforms in the eukaryotic cytosol: mere redundancy or functional specificity? | Q37200825 |
| | Mutations in the C-terminal fragment of DnaK affecting peptide binding | Q37288233 |
| | The mammalian Hsp40 ERdj3 requires its Hsp70 interaction and substrate-binding properties to complement various yeast Hsp40-dependent functions | Q37432019 |
| | Induction of molecular chaperones as a therapeutic strategy for the polyglutamine diseases | Q37694692 |
| | Mechanisms of the Hsp70 chaperone system | Q37746993 |
| P4510 | describes a project that uses | ImageJ | Q1659584 |
| P433 | issue | 18 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | molecular chaperones | Q422496 |
| P304 | page(s) | 2948-2965 | |
| P577 | publication date | 2015-04-23 | |
| P1433 | published in | Journal of Molecular Biology | Q925779 |
| P1476 | title | Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions | |
| P478 | volume | 427 | |