Etomidate Impairs Long-Term Potentiation In Vitro by Targeting α5-Subunit Containing GABAA Receptors on Nonpyramidal Cells

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Etomidate Impairs Long-Term Potentiation In Vitro by Targeting α5-Subunit Containing GABAA Receptors on Nonpyramidal Cells is …
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scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.0315-15.2015
P932PMC publication ID4571505
P698PubMed publication ID26134653

P50authorElif EnginQ50737316
Robert A. PearceQ57431058
P2093author name stringUwe Rudolph
Kurt T Laha
Ewa D Zarnowska
Anja Zeller
Ruth Keist
F Clifford Rodgers
P2860cites workInternational Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. UpdateQ24608968
The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acidQ24654417
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Subunit composition, distribution and function of GABA(A) receptor subtypesQ34143787
OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neuronsQ34304220
Dendritic inhibition in the hippocampus supports fear learningQ34405849
Clinical and molecular pharmacology of etomidateQ35024852
Etomidate blocks LTP and impairs learning but does not enhance tonic inhibition in mice carrying the N265M point mutation in the beta3 subunit of the GABA(A) receptorQ35287581
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Are extrasynaptic GABAA receptors important targets for sedative/hypnotic drugs?Q36207476
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GABAA receptor alpha5 subunits contribute to GABAA,slow synaptic inhibition in mouse hippocampus.Q37152399
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Properties of recombinant gamma-aminobutyric acid A receptor isoforms containing the alpha 5 subunit subtype.Q41189242
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Alpha5GABAA receptor activity sets the threshold for long-term potentiation and constrains hippocampus-dependent memoryQ43099257
Sustained increase in α5GABAA receptor function impairs memory after anesthesiaQ43174617
Etomidate targets alpha5 gamma-aminobutyric acid subtype A receptors to regulate synaptic plasticity and memory blockadeQ43266074
Intact sorting, targeting, and clustering of gamma-aminobutyric acid A receptor subtypes in hippocampal neurons in vitroQ43856121
General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit.Q44244818
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Selective enhancement of tonic GABAergic inhibition in murine hippocampal neurons by low concentrations of the volatile anesthetic isoflurane.Q45084926
Distinct properties of murine alpha 5 gamma-aminobutyric acid type a receptors revealed by biochemical fractionation and mass spectroscopyQ46154987
Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area.Q46610679
Amygdala interneuron subtypes control fear learning through disinhibitionQ47877725
Lifting the fog around anesthesia.Q48090974
Determination of the EC50 amnesic concentration of etomidate and its diffusion profile in brain tissue: implications for in vitro studiesQ48321834
Physiological evidence for two distinct GABAA responses in rat hippocampus.Q48341327
Rat and human hippocampal alpha5 subunit-containing gamma-aminobutyric AcidA receptors have alpha5 beta3 gamma2 pharmacological characteristics.Q48357304
Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor.Q48560999
Alpha5GABAA receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate.Q48592383
GABA(A) receptor subunits in the rat hippocampus I: immunocytochemical distribution of 13 subunits.Q48624478
GABAA receptor subtypes immunopurified from rat brain with α subunit-specific antibodies have unique pharmacological propertiesQ48652513
Regulation of neuronal input transformations by tunable dendritic inhibitionQ48712532
Age-dependent remodelling of inhibitory synapses onto hippocampal CA1 oriens-lacunosum moleculare interneuronsQ48958596
Differential subunit dependence of the actions of the general anesthetics alphaxalone and etomidate at gamma-aminobutyric acid type A receptors expressed in Xenopus laevis oocytes.Q48962204
Polarized distribution of AMPA, but not GABAA , receptors in radial glia-like cells of the adult dentate gyrus.Q50481196
Etomidate potentiation of GABAA receptor gated current depends on the subunit composition.Q51610729
Effects of volatile anesthetics on the kinetics of inhibitory postsynaptic currents in cultured rat hippocampal neurons.Q51655403
Interactions between distinct GABA(A) circuits in hippocampusQ73555196
The synaptic basis of GABAA,slowQ74138476
P4510describes a project that usesImageJQ1659584
P433issue26
P407language of work or nameEnglishQ1860
P921main subjectlong-term potentiationQ1805481
etomidateQ418445
P304page(s)9707-9716
P577publication date2015-07-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleEtomidate Impairs Long-Term Potentiation In Vitro by Targeting α5-Subunit Containing GABAA Receptors on Nonpyramidal Cells
P478volume35

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cites work (P2860)
Q42711568Contrasting Effects of the γ-Aminobutyric Acid Type A Receptor β3 Subunit N265M Mutation on Loss of Righting Reflexes Induced by Etomidate and the Novel Anesthetic Barbiturate R-mTFD-MPAB.
Q47666263Decreasing the Expression of GABAA α5 Subunit-Containing Receptors Partially Improves Cognitive, Electrophysiological, and Morphological Hippocampal Defects in the Ts65Dn Model of Down Syndrome.
Q90316207Input-Specific Synaptic Location and Function of the α5 GABAA Receptor Subunit in the Mouse CA1 Hippocampal Neurons
Q38832005New insights in the systemic and molecular underpinnings of general anesthetic actions mediated by γ-aminobutyric acid A receptors
Q92644507Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum
Q57820716Postacute Delivery of GABA α5 Antagonist Promotes Postischemic Neurological Recovery and Peri-infarct Brain Remodeling
Q39447198The neurophysiological effects of single-dose theophylline in patients with chronic stroke: A double-blind, placebo-controlled, randomized cross-over study
Q37108088The α5 subunit containing GABAA receptors contribute to chronic pain
Q61449922Zolpidem Activation of Alpha 1-Containing GABA Receptors Selectively Inhibits High Frequency Action Potential Firing of Cortical Neurons

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