Generating Virtual Patients by Multivariate and Discrete Re-Sampling Techniques

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Generating Virtual Patients by Multivariate and Discrete Re-Sampling Techniques is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S11095-015-1699-X
P932PMC publication ID4577546
P698PubMed publication ID25994981
P5875ResearchGate publication ID277083168

P50authorFlora Musuamba TshinanuQ80171194
Donato TeutonicoQ83449830
P2093author name stringS Yang
M Danhof
O Della Pasqua
H J Maas
A Facius
P2860cites workThe bootstrap: a tutorialQ30058192
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Biomarker-based Bayesian randomized phase II clinical trial design to identify a sensitive patient subpopulation.Q51088081
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Population pharmacokinetic analysis and simulation of the time-concentration profile of etanercept in pediatric patients with juvenile rheumatoid arthritisQ81386014
Targeting population entering phase III trials: a new stratified adaptive phase II designQ83698290
Actionable gene expression-based patient stratification for molecular targeted therapy in hepatocellular carcinomaQ31119684
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Simulation of clinical trialsQ33932132
Role of modelling and simulation in Phase I drug developmentQ34215804
Considerations in the evaluation of surrogate endpoints in clinical trials. summary of a National Institutes of Health workshopQ34386133
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Prediction of disease progression, treatment response and dropout in chronic obstructive pulmonary disease (COPD)Q34990277
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Modeling interindividual variability in physiologically based pharmacokinetics and its link to mechanistic covariate modelingQ36702459
Genetics-based pediatric warfarin dosage regimen derived using pharmacometric bridgingQ37178373
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Not-in-trial simulation I: Bridging cardiovascular risk from clinical trials to real-life conditionsQ37353460
A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recognQ37404434
An oracle: antituberculosis pharmacokinetics-pharmacodynamics, clinical correlation, and clinical trial simulations to predict the futureQ37799461
Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errorsQ39605793
What predicts change in pulmonary function and quality of life in asthma or COPD?Q39767131
Clinical trial simulation using therapeutic effect modeling: application to ivabradine efficacy in patients with angina pectorisQ40611626
A model for size and age changes in the pharmacokinetics of paracetamol in neonates, infants and childrenQ41597271
Prediction of the outcome of a phase 3 clinical trial of an antischizophrenic agent (quetiapine fumarate) by simulation with a population pharmacokinetic and pharmacodynamic model.Q42638467
Enriched analgesic efficacy studies: an assessment by clinical trial simulationQ42674379
Influence of covariate distribution on the predictive performance of pharmacokinetic models in paediatric researchQ42905874
Protein expression of various hepatic uridine 5'-diphosphate glucuronosyltransferase (UGT) enzymes and their inter-correlations: a meta-analysisQ43816378
Patient stratification in the management of acute bacterial exacerbation of chronic bronchitis: the role of levofloxacin 750 mg.Q46522265
Analysis of dose-response in flexible dose titration clinical studiesQ48032502
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P921main subjectmultivariate statisticsQ1952580
P304page(s)3228-3237
P577publication date2015-05-21
P1433published inPharmaceutical ResearchQ7180737
P1476titleGenerating Virtual Patients by Multivariate and Discrete Re-Sampling Techniques
P478volume32

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cites work (P2860)
Q38674852Evaluating optimal therapy robustness by virtual expansion of a sample population, with a case study in cancer immunotherapy
Q38675644Optimizing drug development in oncology by clinical trial simulation: Why and how?
Q91182307Safety of sacubitril/valsartan initiated during hospitalization: data from a non-selected cohort
Q47634067The Hepato-Hypothalamic-Pituitary-Adrenal-Renal Axis: Mathematical Modeling of Cortisol's Production, Metabolism, and Seasonal Variation

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