Comparison of the HER2, estrogen and progesterone receptor expression profile of primary tumor, metastases and circulating tumor cells in metastatic breast cancer patients

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Comparison of the HER2, estrogen and progesterone receptor expression profile of primary tumor, metastases and circulating tumor cells in metastatic breast cancer patients is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1017036865
P356DOI10.1186/S12885-016-2587-4
P932PMC publication ID4960681
P698PubMed publication ID27456970

P50authorDiethelm WallwienerQ1223199
Sabine Kasimir-BauerQ38290923
Tanja FehmQ38294268
Bahriye AktasQ83188500
P2093author name stringKlaus Pantel
Volkmar Müller
Wolfgang Janni
Mitra Tewes
DETECT Study Group
P2860cites workExpression of stem cell and epithelial-mesenchymal transition markers in circulating tumor cells of breast cancer patientsQ21284707
HER-2 gene amplification can be acquired as breast cancer progressesQ24563115
Discordances in estrogen receptor status, progesterone receptor status, and HER2 status between primary breast cancer and metastasis.Q33777431
HER2-positive circulating tumor cells in breast cancerQ33802925
Can biomarker assessment on circulating tumor cells help direct therapy in metastatic breast cancer?Q33820233
Improving the yield of circulating tumour cells facilitates molecular characterisation and recognition of discordant HER2 amplification in breast cancer.Q33847889
Prospective comparison of switches in biomarker status between primary and recurrent breast cancer: the Breast Recurrence In Tissues Study (BRITS).Q34613506
Receptor conversion in distant breast cancer metastasesQ34989060
Comparison of hormonal receptor and HER-2 status between breast primary tumours and relapsing tumours: clinical implications of progesterone receptor lossQ35082619
Changes in the ER, PgR, HER2, p53 and Ki-67 biological markers between primary and recurrent breast cancer: discordance rates and prognosisQ35546265
Molecular alterations between the primary breast cancer and the subsequent locoregional/metastatic tumorQ35776216
Loss of human epidermal growth factor receptor 2 (HER2) expression in metastatic sites of HER2-overexpressing primary breast tumorsQ35808400
Multimarker Analysis of Circulating Tumor Cells in Peripheral Blood of Metastatic Breast Cancer Patients: A Step Forward in Personalized MedicineQ35909577
Determination of HER2 status using both serum HER2 levels and circulating tumor cells in patients with recurrent breast cancer whose primary tumor was HER2 negative or of unknown HER2 statusQ36458793
Conversion of epidermal growth factor receptor 2 and hormone receptor expression in breast cancer metastases to the brain.Q36924473
Anti-epithelial cell adhesion molecule antibodies and the detection of circulating normal-like breast tumor cells.Q37090760
Prospective study evaluating the impact of tissue confirmation of metastatic disease in patients with breast cancerQ37240839
Does confirmatory tumor biopsy alter the management of breast cancer patients with distant metastases?Q37316222
Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patientsQ37360176
Detection and characterization of circulating tumor cells in blood of primary breast cancer patients by RT-PCR and comparison to status of bone marrow disseminated cellsQ37360230
HER2 discordance between primary breast cancer and its paired metastasis: tumor biology or test artefact? Insights through meta-analysisQ37893534
Unbiased quantitative assessment of Her-2 expression of circulating tumor cells in patients with metastatic and non-metastatic breast cancerQ38070396
HER2 discordance between primary and metastatic breast cancer: assessing the clinical impactQ38114240
ER, HER2, and TOP2A expression in primary tumor, synchronous axillary nodes, and asynchronous metastases in breast cancerQ38409832
Detection and HER2 expression of circulating tumor cells: prospective monitoring in breast cancer patients treated in the neoadjuvant GeparQuattro trialQ39712731
Comparison of assay methods for detection of circulating tumor cells in metastatic breast cancer: AdnaGen AdnaTest BreastCancer Select/Detect™ versus Veridex CellSearch™ systemQ45733272
Clinically used breast cancer markers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are unstable throughout tumor progression.Q46167485
Discordance in receptor status between primary and recurrent breast cancer has a prognostic impact: a single-institution analysisQ46670276
Comparison of estrogen and progesterone receptor status of circulating tumor cells and the primary tumor in metastatic breast cancer patientsQ47586016
Comparative study of the immunohistochemical detection of hormone receptor status and HER-2 expression in primary and paired recurrent/metastatic lesions of patients with breast cancerQ48334436
Breast cancer subtypes and outcome after local and regional relapse.Q51037092
Should liver metastases of breast cancer be biopsied to improve treatment choice?Q51054351
Epithelial-mesenchymal transition and stemness features in circulating tumor cells from breast cancer patients.Q51507853
Discordant human epidermal growth factor receptor 2 and hormone receptor status in primary and metastatic breast cancer and response to trastuzumab.Q53433727
Tissue confirmation of disease recurrence in breast cancer patients: pooled analysis of multi-centre, multi-disciplinary prospective studies.Q54542518
Organotropism and prognostic marker discordance in distant metastases of breast carcinoma: fact or fiction? A clinicopathologic analysis.Q54568017
HER2 protein and gene variation between primary and metastatic breast cancer: significance and impact on patient care.Q54614183
Stability of HER2-positive status in breast carcinoma: a comparison between primary and paired metastatic tumors with regard to the possible impact of intervening trastuzumab treatment.Q54619824
Correlation of HER2 status between primary tumors and corresponding circulating tumor cells in advanced breast cancer patients.Q54732957
Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system.Q55043149
Biopsy of liver metastasis for women with breast cancer: Impact on survivalQ57580716
Change of HER-2/neu status in a subset of distant metastases from breast carcinomasQ80350820
The clinical significance of circulating tumour cells in breast cancer and colorectal cancer patientsQ80531692
HER2 status in a population-derived breast cancer cohort: discordances during tumor progressionQ84566644
Characterization of metastatic breast cancer patients with nondetectable circulating tumor cellsQ85060184
P407language of work or nameEnglishQ1860
P921main subjectmetastatic breast cancerQ12859063
P304page(s)522
P577publication date2016-07-25
P1433published inBMC CancerQ326300
P1476titleComparison of the HER2, estrogen and progesterone receptor expression profile of primary tumor, metastases and circulating tumor cells in metastatic breast cancer patients
P478volume16

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