Ovarian abnormalities in a mouse model of fragile X primary ovarian insufficiency

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Ovarian abnormalities in a mouse model of fragile X primary ovarian insufficiency is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1369/0022155412441002
P932PMC publication ID3393073
P698PubMed publication ID22470123
P5875ResearchGate publication ID223982722

P50authorJodi A FlawsQ63198198
P2093author name stringAli Entezam
Gloria E Hoffman
Wei Wei Le
Karen Usdin
Noriyuki Otsuka
John H McDonald
Lawrence Nelson
Sanjeeda Jafar
Zhi-Bin Tong
P2860cites workThe zona pellucida: using molecular genetics to study the mammalian egg coatQ28139046
From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndromeQ28247567
Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndromeQ28273791
Ablation of the Sam68 gene impairs female fertility and gonadotropin-dependent follicle developmentQ28294438
The FMR1 CGG repeat mouse displays ubiquitin-positive intranuclear neuronal inclusions; implications for the cerebellar tremor/ataxia syndromeQ28507736
Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalanceQ28513538
Hormone-induced proliferation and differentiation of granulosa cells: a coordinated balance of the cell cycle regulators cyclin D2 and p27Kip1Q28564876
The zona pellucida: using molecular genetics to study the mammalian egg coatQ29013390
Isolation of a human DNA sequence which spans the fragile X.Q33373107
Studies of FRAXA and FRAXE in women with premature ovarian failureQ33681082
Fragile-X carrier screening and the prevalence of premutation and full-mutation carriers in Israel.Q34044314
Premature ovarian failure and the FMR1 geneQ34216982
Premature ovarian failure in the fragile X syndromeQ34306135
Reduced FMR1 mRNA translation efficiency in fragile X patients with premutations.Q34364858
Fragile X syndrome: a model of gene-brain-behavior relationshipsQ34396131
Impairment of proteasome structure and function in aging.Q34801742
CGG-repeat length threshold for FMR1 RNA pathogenesis in a cellular model for FXTASQ34955465
Ubiquitin-proteasome pathway and cellular responses to oxidative stressQ35027877
Predictors and risk model development for menopausal age in fragile X premutation carriersQ35093727
Altered hypothalamus-pituitary-adrenal gland axis regulation in the expanded CGG-repeat mouse model for fragile X-associated tremor/ataxia syndromeQ35533280
Quantitative comparison of FMR1 gene expression in normal and premutation allelesQ35643830
Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain.Q35869366
Regional FMRP deficits and large repeat expansions into the full mutation range in a new Fragile X premutation mouse modelQ35944748
Pur alpha binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of fragile X tremor/ataxia syndrome.Q36014935
Treatment of fragile X-associated tremor ataxia syndrome (FXTAS) and related neurological problemsQ36897434
Serum concentrations of follicle stimulating hormone may predict premature ovarian failure in FRAXA premutation womenQ37058031
Messenger RNA for neuropeptide Y in the arcuate nucleus increases in parallel with plasma adrenocorticotropin during sepsis in the ratQ37181098
Ectopic expression of CGG containing mRNA is neurotoxic in mammalsQ37223278
The fragile X syndrome repeats form RNA hairpins that do not activate the interferon-inducible protein kinase, PKR, but are cut by DicerQ37369000
Genetically modified mouse models for premature ovarian failure (POF).Q37566710
The ubiquitous role of ubiquitin in the DNA damage responseQ37807639
Ovarian structure in cases of primary and secondary infertility.Q38998079
Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patientsQ40117267
RNA-binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS.Q42975231
Effect of bcl-2 on the primordial follicle endowment in the mouse ovaryQ43458001
Suckling stimulus suppresses messenger RNA for tyrosine hydroxylase in arcuate neurons during lactationQ43739600
Alterations in peripheral concentrations of inhibin A in cattle studied using a time-resolved immunofluorometric assay: relationship with estradiol and follicle-stimulating hormone in various reproductive conditionsQ44038689
FMR1 premutation carrier frequency in patients undergoing routine population-based carrier screening: insights into the prevalence of fragile X syndrome, fragile X-associated tremor/ataxia syndrome, and fragile X-associated primary ovarian insufficiQ44165815
Induction of inclusion formation and disruption of lamin A/C structure by premutation CGG-repeat RNA in human cultured neural cellsQ45031515
Evidence of early ovarian aging in fragile X premutation carriersQ45050634
Neuronal intranuclear inclusions in a new cerebellar tremor/ataxia syndrome among fragile X carriersQ46124789
RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in DrosophilaQ47071910
Size-frequency analysis of atresia in cycling ratsQ47180417
Olfactory and vomeronasal deafferentation of male hamsters: histological and behavioral analysesQ48292965
Use of cryoprotectant to maintain long-term peptide immunoreactivity and tissue morphologyQ48406116
Changes in hypothalamic corticotropin-releasing hormone, neuropeptide Y, and proopiomelanocortin gene expression during chronic rapid eye movement sleep deprivation of ratsQ48530848
Ovarian reserve determinations suggest new function of FMR1 (fragile X gene) in regulating ovarian ageingQ48701983
Anti-Müllerian hormone inhibits initiation of primordial follicle growth in the mouse ovaryQ48868225
Reduced FMRP and increased FMR1 transcription is proportionally associated with CGG repeat number in intermediate-length and premutation carriers.Q51965229
Implications of the FMR1 gene in menopause: study of 147 Spanish women.Q51968564
Association between idiopathic premature ovarian failure and fragile X premutation.Q51978995
Clinical involvement and protein expression in individuals with the FMR1 premutation.Q52169510
Is early natural menopause a biologic marker of health and aging?Q54783693
Stathmokinetic analysis of granulosa cell proliferation in antral follicles of cyclic ratsQ70795552
FRAXA premutation associated with premature ovarian failureQ71621167
Imminent oocyte exhaustion and reduced follicular recruitment mark the transition to acyclicity in aging C57BL/6J miceQ71702598
A longitudinal study of estrous cyclicity in aging C57BL/6J mice: I. Cycle frequency, length and vaginal cytologyQ71840590
Immunocytochemical and biochemical characterization of FMRP, FXR1P, and FXR2P in the mouseQ74060519
Premature ovarian failure and fragile X premutation: a study on 45 womenQ75345114
Twinning and premature ovarian failure in premutation fragile X carriersQ77339395
Pathological changes in the reproductive organs of cows and heifers culled because of infertilityQ78540999
Estimation of nuclear population from microtome sectionsQ82126847
X chromosome inactivation does not define the development of premature ovarian failure in fragile X premutation carriersQ82647770
P433issue6
P304page(s)439-456
P577publication date2012-04-02
P1433published inJournal of Histochemistry and CytochemistryQ1523992
P1476titleOvarian abnormalities in a mouse model of fragile X primary ovarian insufficiency
P478volume60

Reverse relations

cites work (P2860)
Q33617701Association of skewed X-chromosome inactivation with FMR1 CGG repeat length and anti-Mullerian hormone levels: a cohort study
Q35541848Curvilinear association of CGG repeats and age at menopause in women with FMR1 premutation expansions
Q40697612Early decline in functional ovarian reserve in young women with low (CGGn < 26) FMR1 gene alleles
Q34074523Expression of an expanded CGG-repeat RNA in a single pair of primary sensory neurons impairs olfactory adaptation in Caenorhabditis elegans
Q37451133FMR1 CGG expansions: prevalence and sex ratios
Q37115382FMR1-dependent variability of ovarian aging patterns is already apparent in young oocyte donors
Q36151280FMRP Associates with Cytoplasmic Granules at the Onset of Meiosis in the Human Oocyte
Q59806856Fragile X Associated Primary Ovarian Insufficiency (FXPOI): Case Report and Literature Review
Q36375813Fragile X premutation RNA is sufficient to cause primary ovarian insufficiency in mice
Q39375765Fragile X syndrome: an overview and update of the FMR1 gene.
Q37524454Fragile X-associated tremor/ataxia syndrome (FXTAS): pathology and mechanisms
Q36946491Granulosa cell and oocyte mitochondrial abnormalities in a mouse model of fragile X primary ovarian insufficiency.
Q34106386How the FMR1 gene became relevant to female fertility and reproductive medicine
Q90699685In silico, in vitro, and in vivo Approaches to Identify Molecular Players in Fragile X Tremor and Ataxia Syndrome
Q33786496Intermediate CGG repeat length at the FMR1 locus is not associated with hormonal indicators of ovarian age.
Q38605681Molecular insights into the aetiology of female reproductive ageing.
Q34055453Mouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndrome
Q41258345Newborn screening for fragile X syndrome
Q47556307Premature recruitment of oocyte pool and increased mTOR activity in Fmr1 knockout mice and reversal of phenotype with rapamycin
Q36368705Presence of inclusions positive for polyglycine containing protein, FMRpolyG, indicates that repeat-associated non-AUG translation plays a role in fragile X-associated primary ovarian insufficiency
Q37586512Quantifying growing versus non-growing ovarian follicles in the mouse
Q33732476RNA-binding proteins in human oogenesis: Balancing differentiation and self-renewal in the female fetal germline
Q49905433Repeat-associated non-AUG (RAN) translation and other molecular mechanisms in Fragile X Tremor Ataxia Syndrome.
Q41144516Reproductive and gynecologic care of women with fragile X primary ovarian insufficiency (FXPOI).
Q27324731Skin-derived mesenchymal stem cells help restore function to ovaries in a premature ovarian failure mouse model
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Q28077015Study of the Genetic Etiology of Primary Ovarian Insufficiency: FMR1 Gene
Q27026782The FMR1 gene, infertility, and reproductive decision-making: a review
Q48577134The Stage- and Cell Type-Specific Localization of Fragile X Mental Retardation Protein in Rat Ovaries
Q42398270The importance of redundancy of functional ovarian reserve when investigating potential genetic effects on ovarian function
Q34077084Understanding decreased fertility in women carriers of the FMR1 premutation: a possible mechanism for Fragile X-Associated Primary Ovarian Insufficiency (FXPOI).
Q89172366Use of human-derived stem cells to create a novel, in vitro model designed to explore FMR1 CGG repeat instability amongst female premutation carriers
Q21198724Use of model systems to understand the etiology of fragile X-associated primary ovarian insufficiency (FXPOI)

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