Silencing the Transcriptional Repressor, ZCT1, Illustrates the Tight Regulation of Terpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus Hairy Roots

scientific article published on 28 July 2016

Silencing the Transcriptional Repressor, ZCT1, Illustrates the Tight Regulation of Terpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus Hairy Roots is …
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scholarly articleQ13442814

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P819ADS bibcode2016PLoSO..1159712R
P356DOI10.1371/JOURNAL.PONE.0159712
P932PMC publication ID4965073
P698PubMed publication ID27467510

P2093author name stringErin J Cram
Carolyn W T Lee-Parsons
Noreen F Rizvi
Jessica D Weaver
P2860cites workThe transcription factor CrWRKY1 positively regulates the terpenoid indole alkaloid biosynthesis in Catharanthus roseusQ45834174
Transcriptional response of the terpenoid indole alkaloid pathway to the overexpression of ORCA3 along with jasmonic acid elicitation of Catharanthus roseus hairy roots over time.Q46291982
Expression of the Arabidopsis feedback-insensitive anthranilate synthase holoenzyme and tryptophan decarboxylase genes in Catharanthus roseus hairy roots.Q46723971
Jasmonate-dependent alkaloid biosynthesis in Catharanthus Roseus hairy root cultures is correlated with the relative expression of Orca and Zct transcription factorsQ47718693
A Catharanthus roseus BPF-1 homologue interacts with an elicitor-responsive region of the secondary metabolite biosynthetic gene Str and is induced by elicitor via a JA-independent signal transduction pathway.Q48379943
Effect of precursor feeding on alkaloid accumulation by a strictosidine synthase over-expressing transgenic cell line S1 of Catharanthus roseusQ57058208
JAZ repressor proteins are targets of the SCFCOI1 complex during jasmonate signallingQ58619723
The expression of 1-deoxy-d-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy rootsQ61457352
Determination of metabolic rate-limitations by precursor feeding in Catharanthus roseus hairy root culturesQ61457384
Production of indole alkaloids by selected hairy root lines ofCatharanthus roseusQ61457408
The ORCA2 transcription factor plays a key role in regulation of the terpenoid indole alkaloid pathwayQ31140870
CrMYC1, a Catharanthus roseus elicitor- and jasmonate-responsive bHLH transcription factor that binds the G-box element of the strictosidine synthase gene promoter.Q31156416
The jasmonate-inducible AP2/ERF-domain transcription factor ORCA3 activates gene expression via interaction with a jasmonate-responsive promoter elementQ31908625
A novel jasmonate- and elicitor-responsive element in the periwinkle secondary metabolite biosynthetic gene Str interacts with a jasmonate- and elicitor-inducible AP2-domain transcription factor, ORCA2.Q33871182
The Catharanthus alkaloids: pharmacognosy and biotechnologyQ34307168
Technical advance: An estrogen receptor-based transactivator XVE mediates highly inducible gene expression in transgenic plants.Q34511822
The JAZ family of repressors is the missing link in jasmonate signalling.Q34652938
The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus.Q35818649
Perspectives of the metabolic engineering of terpenoid indole alkaloids in Catharanthus roseus hairy rootsQ38098107
The basic helix-loop-helix transcription factor CrMYC2 controls the jasmonate-responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus.Q39576504
Effect of precursor feeding on alkaloid accumulation by a tryptophan decarboxylase over-expressing transgenic cell line T22 of Catharanthus roseusQ40728413
ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolismQ40868493
Influence of Precursor Availability on Alkaloid Accumulation by Transgenic Cell Line of Catharanthus roseusQ41061516
Genome-guided investigation of plant natural product biosynthesisQ41378077
ZCT1 and ZCT2 transcription factors repress the activity of a gene promoter from the methyl erythritol phosphate pathway in Madagascar periwinkle cells.Q41383408
Transcriptional response of the catharanthine biosynthesis pathway to methyl jasmonate/nitric oxide elicitation in Catharanthus roseus hairy root cultureQ42935593
Overexpression of G10H and ORCA3 in the hairy roots of Catharanthus roseus improves catharanthine productionQ43036206
Assessing the limitations to terpenoid indole alkaloid biosynthesis in Catharanthus roseus hairy root cultures through gene expression profiling and precursor feedingQ43282676
Catharanthus roseus G-box binding factors 1 and 2 act as repressors of strictosidine synthase gene expression in cell culturesQ43607286
Expression of a feedback-resistant anthranilate synthase in Catharanthus roseus hairy roots provides evidence for tight regulation of terpenoid indole alkaloid levelsQ44891583
Zinc finger proteins act as transcriptional repressors of alkaloid biosynthesis genes in Catharanthus roseus.Q45091136
Metabolic engineering of the indole pathway in Catharanthus roseus hairy roots and increased accumulation of tryptamine and serpentine.Q45112867
Precursor limitations in methyl jasmonate-induced Catharanthus roseus cell culturesQ45299909
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectCatharanthus roseusQ161093
terpenoidsQ426694
P304page(s)e0159712
P577publication date2016-07-28
P1433published inPLOS OneQ564954
P1476titleSilencing the Transcriptional Repressor, ZCT1, Illustrates the Tight Regulation of Terpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus Hairy Roots
P478volume11

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cites work (P2860)
Q41362849A differentially regulated AP2/ERF transcription factor gene cluster acts downstream of a MAP kinase cascade to modulate terpenoid indole alkaloid biosynthesis in Catharanthus roseus
Q37657589The miRNAome of Catharanthus roseus: identification, expression analysis, and potential roles of microRNAs in regulation of terpenoid indole alkaloid biosynthesis
Q92466296The regulation of ZCT1, a transcriptional repressor of monoterpenoid indole alkaloid biosynthetic genes in Catharanthus roseus
Q37631456Transcriptional Regulation and Transport of Terpenoid Indole Alkaloid in Catharanthus roseus: Exploration of New Research Directions
Q101574351UPLC/MS-based untargeted metabolomics reveals the changes of metabolites profile of Salvia miltiorrhiza bunge during Sweating processing
Q64060871croFGD: Functional Genomics Database

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