Rhes: a GTP-binding protein integral to striatal physiology and pathology

scientific article

Rhes: a GTP-binding protein integral to striatal physiology and pathology is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10571-012-9830-6
P932PMC publication ID3396771
P698PubMed publication ID22450871

P2093author name stringLaura M Harrison
P2860cites workFunctional organization of the basal ganglia: Therapeutic implications for Parkinson's diseaseQ22252880
Activation of heterotrimeric G-protein signaling by a ras-related protein. Implications for signal integrationQ22254214
Genes expressed in human tumor endotheliumQ24290105
Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic beta-cellQ24295155
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behaviorQ24310712
The cationic region of Rhes mediates its interactions with specific Gbeta subunitsQ24316984
Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicityQ24317318
Gem: an induced, immediate early protein belonging to the Ras familyQ24319763
Neurocircuitry of addictionQ24647156
Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPONQ28138253
The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptorsQ28238833
Increased response to morphine in mice lacking protein kinase C epsilonQ28256829
Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 cellsQ28260734
Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulationQ28479035
The GTP-binding protein Rhes modulates dopamine signalling in striatal medium spiny neuronsQ28507220
Thyroid hormone regulation of rhes, a novel Ras homolog gene expressed in the striatumQ43764413
Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC gamma mutant miceQ43814056
Phosphorylation of neurogranin, protein kinase C, and Ca2+/calmodulin dependent protein kinase II in opioid tolerance and dependenceQ44331256
Differential effects of triiodothyronine and the thyroid hormone receptor beta-specific agonist GC-1 on thyroid hormone target genes in the b ain.Q44576078
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophreniaQ44743796
T3 administration in adult hypothyroid mice modulates expression of proteins involved in striatal synaptic plasticity and improves motor behaviorQ46514333
Monomeric G-protein, Rhes, is not an imidazoline-regulated protein in pancreatic beta-cellsQ46796872
Regulation of phosphorylation of the GluR1 AMPA receptor by dopamine D2 receptorsQ46841675
Rhes, the Ras homolog enriched in striatum, is reduced under conditions of dopamine supersensitivityQ46849612
Conservation of behavioural topography to dopamine D1-like receptor agonists in mutant mice lacking the D1A receptor implicates a D1-like receptor not coupled to adenylyl cyclaseQ48103731
Evidence for a distinct D1-like dopamine receptor that couples to activation of phosphoinositide metabolism in brain.Q48136063
Cloning and expression of an adenylyl cyclase localized to the corpus striatumQ48332642
Quantification of lesion-induced dopaminergic supersensitivity using the rotational model in the mouseQ48506647
Computer-assisted video analysis of [3H]spiroperidol binding autoradiographs.Q48554202
Ontogenetic expression of D2 dopamine receptor mRNA in rat corpus striatumQ48623419
DARPP-32 development in the caudate nucleus is independent of afferent input from the substantia nigraQ48947150
RASD2, MYH9, and CACNG2 genes at chromosome 22q12 associated with the subgroup of schizophrenia with non-deficit in sustained attention and executive function.Q51889379
Supersensitivity to apomorphine following destruction of the ascending dopamine neurons: Quantification using the rotational modelQ67010898
A comparison of D1 receptor binding and mRNA in rat brain using receptor autoradiographic and in situ hybridization techniquesQ68053421
Thyroid hormones and brain developmentQ71795485
Dopaminergic behaviors and signal transduction mediated through adenylate cyclase and phospholipase C pathwaysQ73426209
Thyroid hormone receptor alpha plays an essential role in the normalisation of adult-onset hypothyroidism-related hypoexpression of synaptic plasticity target genes in striatumQ83022607
G-protein gamma 7 subunit is selectively expressed in medium-sized neurons and dendrites of the rat neostriatumQ28577123
Rhes: A striatal-specific Ras homolog related to Dexras1Q28578297
Raf-1 and B-Raf proteins have similar regional distributions but differential subcellular localization in adult rat brainQ28581195
Rhes is involved in striatal functionQ28589966
The Ras homolog Rhes affects dopamine D1 and D2 receptor-mediated behavior in miceQ28594205
A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regionsQ28643908
Detection, validation, and downstream analysis of allelic variation in gene expressionQ28749381
Differential targeting of Gbetagamma-subunit signaling with small moleculesQ33240532
Differential vulnerability of neurons in Huntington's disease: the role of cell type-specific featuresQ33931283
A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferateQ33948589
Rhes, a physiologic regulator of sumoylation, enhances cross-sumoylation between the basic sumoylation enzymes E1 and Ubc9.Q33966800
Mice lacking rhes show altered morphine analgesia, tolerance, and dependenceQ34559512
Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent processQ34562286
A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signalsQ34611677
Ras homolog enriched in striatum inhibits the functional activity of wild type thyrotropin, follicle-stimulating hormone, luteinizing hormone receptors and activating thyrotropin receptor mutations by altering their expression in COS-7 cellsQ34635678
Rhes and AGS1/Dexras1 affect signaling by dopamine D1 receptors through adenylyl cyclaseQ34798869
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtinQ35013054
Involvement of phospholipid signal transduction pathways in morphine tolerance in miceQ35041461
Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioidsQ35621680
Isolation of clones of rat striatum-specific mRNAs by directional tag PCR subtractionQ36735678
Activator of G protein signaling 3: a gatekeeper of cocaine sensitization and drug seeking.Q36747977
Antagonism of dopamine D2 receptor/beta-arrestin 2 interaction is a common property of clinically effective antipsychotics.Q36870038
Ontogeny and dopaminergic regulation in brain of Ras homolog enriched in striatum (Rhes)Q37041675
A novel Gbetagamma-subunit inhibitor selectively modulates mu-opioid-dependent antinociception and attenuates acute morphine-induced antinociceptive tolerance and dependenceQ37107564
Basal ganglia pathology in schizophrenia: dopamine connections and anomalies.Q37678649
Huntington's disease is a disorder of the corpus striatum: focus on Rhes (Ras homologue enriched in the striatum)Q37806394
Rem is a new member of the Rad- and Gem/Kir Ras-related GTP-binding protein family repressed by lipopolysaccharide stimulationQ38343317
Dopamine D-2 receptors in rat caudate-putamen: the lateral to medial gradient does not correspond to dopaminergic innervationQ39291077
Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia.Q39426286
The monomeric G proteins AGS1 and Rhes selectively influence Galphai-dependent signaling to modulate N-type (CaV2.2) calcium channels.Q39936146
Dexras1/AGS-1, a steroid hormone-induced guanosine triphosphate-binding protein, inhibits 3',5'-cyclic adenosine monophosphate-stimulated secretion in AtT-20 corticotroph cellsQ40805615
The role of thyroid hormones in prenatal and neonatal neurological development--current perspectivesQ40906178
Dopamine supersensitivity and D1/D2 synergism are unrelated to changes in striatal receptor densityQ41090735
Localization of dopamine D2 receptor mRNA and D1 and D2 receptor binding in the rat brain and pituitary: an in situ hybridization-receptor autoradiographic analysisQ41187561
Neonatal dopamine lesion in the rat results in enhanced adenylate cyclase activity without altering dopamine receptor binding or dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein (DARPP-32) immunoreactivityQ42475169
G(olf) and Gs in rat basal ganglia: possible involvement of G(olf) in the coupling of dopamine D1 receptor with adenylyl cyclaseQ42511423
Selective tissue distribution of G protein gamma subunits, including a new form of the gamma subunits identified by cDNA cloningQ42603185
P433issue6
P921main subjectstriatumQ1319792
P304page(s)907-918
P577publication date2012-03-27
P1433published inCellular and Molecular NeurobiologyQ2333197
P1476titleRhes: a GTP-binding protein integral to striatal physiology and pathology
P478volume32

Reverse relations

cites work (P2860)
Q36680959Effects of the Ras homolog Rhes on Akt/protein kinase B and glycogen synthase kinase 3 phosphorylation in striatum
Q90029591Exaggerated mitophagy: a weapon of striatal destruction in the brain?
Q64107446Lack of Rhes Increases MDMA-Induced Neuroinflammation and Dopamine Neuron Degeneration: Role of Gender and Age
Q37482165RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum
Q36112209Sea lampreys elicit strong transcriptomic responses in the lake trout liver during parasitism
Q38211024Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes.
Q38098802The role of Rhes, Ras homolog enriched in striatum, in neurodegenerative processes
Q90950669The striatal-enriched protein Rhes is a critical modulator of cocaine-induced molecular and behavioral responses
Q38572489Therapeutic advances in dystonia

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