Mitogen-activated protein kinase pathways and fungal pathogenesis

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Mitogen-activated protein kinase pathways and fungal pathogenesis is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1128/EC.00216-07
P932PMC publication ID2043402
P698PubMed publication ID17715363
P5875ResearchGate publication ID6125391

P2093author name stringRahim Mehrabi
Xinhua Zhao
Jin-Rong Xu
P2860cites workThe genome sequence of the rice blast fungus Magnaporthe griseaQ22122482
MAP kinase pathways in the yeast Saccharomyces cerevisiaeQ24548569
Novel G-protein-coupled receptor-like proteins in the plant pathogenic fungus Magnaporthe griseaQ24797300
Regulation of mating and filamentation genes by two distinct Ste12 complexes in Saccharomyces cerevisiaeQ27932174
The MAPK Hog1p modulates Fps1p-dependent arsenite uptake and tolerance in yeast.Q27933186
A third osmosensing branch in Saccharomyces cerevisiae requires the Msb2 protein and functions in parallel with the Sho1 branchQ27934962
The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway.Q27935451
Regulation of the yeast Rlm1 transcription factor by the Mpk1 cell wall integrity MAP kinase.Q27936197
Protein kinase A operates a molecular switch that governs yeast pseudohyphal differentiationQ27937159
Cryptococcus neoformans STE12alpha regulates virulence but is not essential for matingQ27939881
Osmotic stress signaling and osmoadaptation in yeastsQ29617597
Nonfilamentous C. albicans mutants are avirulentQ29617839
Aspergillus nidulans HOG pathway is activated only by two-component signalling pathway in response to osmotic stressQ30160244
The ubc2 gene of Ustilago maydis encodes a putative novel adaptor protein required for filamentous growth, pheromone response and virulenceQ30167897
An ste20 homologue in Ustilago maydis plays a role in mating and pathogenicity.Q31044238
Two novel fungal virulence genes specifically expressed in appressoria of the rice blast fungusQ31108370
The induction of sexual development and virulence in the smut fungus Ustilago maydis depends on Crk1, a novel MAPK proteinQ33209925
MgSlt2, a cellular integrity MAP kinase gene of the fungal wheat pathogen Mycosphaerella graminicola, is dispensable for penetration but essential for invasive growthQ33239732
Mutations in VMK1, a mitogen-activated protein kinase gene, affect microsclerotia formation and pathogenicity in Verticillium dahliaeQ61464897
The role of the sakA (Hog1) and tcsB (sln1) genes in the oxidant adaptation of Aspergillus fumigatusQ61497775
Targeting antioxidative signal transduction and stress response system: control of pathogenic Aspergillus with phenolics that inhibit mitochondrial functionQ61497784
A MAP kinase cascade composed of cell type specific and non-specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformansQ62629892
Osmotic stress-coupled maintenance of polar growth in Aspergillus nidulansQ62656933
Magnaporthe grisea pth11p is a novel plasma membrane protein that mediates appressorium differentiation in response to inductive substrate cuesQ73083355
A role for the MAP kinase gene MKC1 in cell wall construction and morphological transitions in Candida albicansQ74285641
CPMK2, an SLT2-homologous mitogen-activated protein (MAP) kinase, is essential for pathogenesis of Claviceps purpurea on rye: evidence for a second conserved pathogenesis-related MAP kinase cascade in phytopathogenic fungiQ78445893
Functional studies of the Ssk1p response regulator protein of Candida albicans as determined by phenotypic analysis of receiver domain point mutantsQ79233052
Hog1p mitogen-activated protein kinase determines acetic acid resistance in Saccharomyces cerevisiaeQ79420008
The Mep2p ammonium permease controls nitrogen starvation-induced filamentous growth in Candida albicansQ81631164
Characterization and complementation of a Fus3/Kss1 type MAPK from Tuber borchii, TBMKQ83357990
G-protein beta subunit of Cochliobolus heterostrophus involved in virulence, asexual and sexual reproductive ability, and morphogenesisQ33559760
Cellular localization and role of kinase activity of PMK1 in Magnaporthe griseaQ33559766
Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformansQ33768483
Properties of various Rho1 mutant alleles of Cryptococcus neoformansQ33791723
Induction of the Candida albicans filamentous growth program by relief of transcriptional repression: a genome-wide analysisQ33841447
A CDC42 homologue in Claviceps purpurea is involved in vegetative differentiation and is essential for pathogenicityQ33884517
Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformansQ33905126
A contact-activated kinase signals Candida albicans invasive growth and biofilm developmentQ33936541
Conserved cAMP signaling cascades regulate fungal development and virulenceQ33946381
Identification and characterization of an SKN7 homologue in Cryptococcus neoformansQ33946817
Signal transduction cascades regulating fungal development and virulence.Q34010291
White-opaque switching in Candida albicans is controlled by mating-type locus homeodomain proteins and allows efficient matingQ34144354
Map kinases in fungal pathogensQ34198348
G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformansQ34325690
Mating in Candida albicans and the search for a sexual cycleQ34420674
A mitogen-activated protein kinase pathway essential for mating and contributing to vegetative growth in Neurospora crassaQ34576493
The isolation and characterization of nrc-1 and nrc-2, two genes encoding protein kinases that control growth and development in Neurospora crassaQ34604356
The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformansQ34608349
TUP1, CPH1 and EFG1 make independent contributions to filamentation in candida albicansQ34609405
An STE12 homolog from the asexual, dimorphic fungus Penicillium marneffei complements the defect in sexual development of an Aspergillus nidulans steA mutant.Q34612036
A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformansQ34698188
A mitotically inheritable unit containing a MAP kinase moduleQ35037293
Of smuts, blasts, mildews, and blights: cAMP signaling in phytopathogenic fungiQ35090242
The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin functionQ35128586
Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP.Q35197981
Novel mitogen-activated protein kinase MpkC of Aspergillus fumigatus is required for utilization of polyalcohol sugarsQ35216706
Reduced virulence of Candida albicans MKC1 mutants: a role for mitogen-activated protein kinase in pathogenesisQ35567860
Rgs1 regulates multiple Galpha subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism.Q35629671
Ste12 transcription factor homologue CpST12 is down-regulated by hypovirus infection and required for virulence and female fertility of the chestnut blight fungus Cryphonectria parasiticaQ35636479
Melanin biosynthesis in the maize pathogen Cochliobolus heterostrophus depends on two mitogen-activated protein kinases, Chk1 and Mps1, and the transcription factor Cmr1.Q35690231
Importance of a developmentally regulated pheromone receptor of Cryptococcus neoformans for virulenceQ35802299
The response regulator RRG-1 functions upstream of a mitogen-activated protein kinase pathway impacting asexual development, female fertility, osmotic stress, and fungicide resistance in Neurospora crassaQ35810689
A walk-through of the yeast mating pheromone response pathwayQ35890686
Principles of MAP kinase signaling specificity in Saccharomyces cerevisiae.Q35965868
Farnesol, a morphogenetic autoregulatory substance in the dimorphic fungus Candida albicans, inhibits hyphae growth through suppression of a mitogen-activated protein kinase cascadeQ44888389
The Fus3/Kss1 MAP kinase homolog Amk1 regulates the expression of genes encoding hydrolytic enzymes in Alternaria brassicicolaQ44926868
Fungicide activity through activation of a fungal signalling pathway.Q45040135
The G‐beta subunit MGB1 is involved in regulating multiple steps of infection‐related morphogenesis in Magnaporthe griseaQ45103449
The Gpmk1 MAP kinase of Fusarium graminearum regulates the induction of specific secreted enzymesQ45153906
Fusarium oxysporum G-protein beta subunit Fgb1 regulates hyphal growth, development, and virulence through multiple signalling pathwaysQ45180761
A two-component histidine kinase of the rice blast fungus is involved in osmotic stress response and fungicide actionQ45262658
A secreted lipase of Fusarium graminearum is a virulence factor required for infection of cerealsQ46447327
The MAP kinase Mkc1p is activated under different stress conditions in Candida albicans.Q46633733
Cell signaling pathways in Paracoccidioides brasiliensis--inferred from comparisons with other fungiQ46658803
The importance of the phagocytes' innate response in resolution of the infection induced by a low virulent Candida albicans mutant.Q46716413
A downshift in temperature activates the high osmolarity glycerol (HOG) pathway, which determines freeze tolerance in Saccharomyces cerevisiaeQ46863312
Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformansQ46973362
Expression analysis of PCSTE3, a putative pheromone receptor from the lung pathogenic fungus Pneumocystis cariniiQ47441016
Two PAK kinase genes, CHM1 and MST20, have distinct functions in Magnaporthe griseaQ47608558
MAPK regulation of sclerotial development in Sclerotinia sclerotiorum is linked with pH and cAMP sensingQ47783969
The BMP1 gene is essential for pathogenicity in the gray mold fungus Botrytis cinereaQ47848950
RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformansQ47863650
Aspergillus SteA (sterile12-like) is a homeodomain-C2/H2-Zn+2 finger transcription factor required for sexual reproductionQ47863679
A mitogen-activated protein kinase (MPKA) is involved in polarized growth in the filamentous fungus, Aspergillus nidulansQ47968910
G protein alpha subunit genes control growth, development, and pathogenicity of Magnaporthe griseaQ48042118
Complementation of Ustilago maydis MAPK mutants by a wheat leaf rust, Puccinia triticina homolog: potential for functional analyses of rust genesQ48078969
A highly conserved MAPK-docking site in Mst7 is essential for Pmk1 activation in Magnaporthe griseaQ48082375
MgHog1 regulates dimorphism and pathogenicity in the fungal wheat pathogen Mycosphaerella graminicola.Q48083770
Multiple upstream signals converge on the adaptor protein Mst50 in Magnaporthe griseaQ48083934
Disruption of SRM1, a mitogen-activated protein kinase gene, affects sensitivity to osmotic and ultraviolet stressors in the phytopathogenic fungus Bipolaris oryzaeQ48095350
A MAP kinase gene, BMK1, is required for conidiation and pathogenicity in the rice leaf spot pathogen Bipolaris oryzaeQ48095866
Characterization of the ERK homologue CpMK2 from the chestnut blight fungus Cryphonectria parasiticaQ48139567
A mitogen-activated protein kinase cascade regulating infection-related morphogenesis in Magnaporthe griseaQ48148021
Pneumocystis carinii BCK1 functions in a mitogen-activated protein kinase cascade regulating fungal cell-wall assemblyQ48235120
The Colletotrichum lagenarium Ste12-Like Gene CST1 Is Essential for Appressorium PenetrationQ48246930
The MAPKK kinase SteC regulates conidiophore morphology and is essential for heterokaryon formation and sexual development in the homothallic fungus Aspergillus nidulansQ48256556
A conserved mitogen-activated protein kinase pathway is required for mating in Candida albicansQ48272020
SakA MAP kinase is involved in stress signal transduction, sexual development and spore viability in Aspergillus nidulans.Q48287453
The biotrophic, non-appressorium-forming grass pathogen Claviceps purpurea needs a Fus3/Pmk1 homologous mitogen-activated protein kinase for colonization of rye ovarian tissueQ48303186
The Cryptococcus neoformans STE11alpha gene is similar to other fungal mitogen-activated protein kinase kinase kinase (MAPKKK) genes but is mating type specificQ48370584
PTK1, a mitogen-activated-protein kinase gene, is required for conidiation, appressorium formation, and pathogenicity of Pyrenophora teres on barleyQ48379833
The Pbs2 MAP kinase kinase is essential for the oxidative-stress response in the fungal pathogen Candida albicans.Q50772221
Characterization of HOG1 homologue, CpMK1, from Cryphonectria parasitica and evidence for hypovirus-mediated perturbation of its phosphorylation in response to hypertonic stress.Q51020923
A class III histidine kinase acts as a novel virulence factor in Botrytis cinerea.Q51139198
MAP kinase and cAMP signaling pathways modulate the pH-induced yeast-to-mycelium dimorphic transition in the corn smut fungus Ustilago maydis.Q51611150
A screen in Saccharomyces cerevisiae identified CaMCM1, an essential gene in Candida albicans crucial for morphogenesis.Q52109258
The Mak2 MAP kinase signal transduction pathway is required for pathogenicity in Stagonospora nodorum.Q52565253
Roles of putative His-to-Asp signaling modules HPT-1 and RRG-2, on viability and sensitivity to osmotic and oxidative stresses in Neurospora crassa.Q52576114
Independent genetic mechanisms mediate turgor generation and penetration peg formation during plant infection in the rice blast fungus.Q53635213
The isolation of FOS-1, a gene encoding a putative two-component histidine kinase from Aspergillus fumigatus.Q54026697
Saccharomyces cerevisiae Hog1 protein phosphorylation upon exposure to bacterial endotoxin.Q54462882
Identification of OS-2 MAP kinase-dependent genes induced in response to osmotic stress, antifungal agent fludioxonil, and heat shock in Neurospora crassa.Q54579960
Distinct signalling pathways coordinately contribute to virulence of Fusarium oxysporum on mammalian hostsQ56970921
Independent Signaling Pathways Regulate Cellular Turgor during Hyperosmotic Stress and Appressorium-Mediated Plant Infection by Magnaporthe griseaQ57362543
Regulation of the osmoregulatory HOG MAPK cascade in yeastQ35983907
Baker's yeast as a tool for the development of antifungal kinase inhibitors--targeting protein kinase C and the cell integrity pathwayQ36282514
Candida albicans response regulator gene SSK1 regulates a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stressQ36370450
Two-component signal transduction in human fungal pathogensQ36399917
The MAP kinase signal transduction network in Candida albicans.Q36426498
Inactivation of the mitogen-activated protein kinase Mps1 from the rice blast fungus prevents penetration of host cells but allows activation of plant defense responsesQ36531836
A mitogen-activated protein kinase of the corn leaf pathogen Cochliobolus heterostrophus is involved in conidiation, appressorium formation, and pathogenicity: diverse roles for mitogen-activated protein kinase homologs in foliar pathogens.Q36680610
Role of a mitogen-activated protein kinase pathway during conidial germination and hyphal fusion in Neurospora crassaQ37421767
A mitogen-activated protein kinase that senses nitrogen regulates conidial germination and growth in Aspergillus fumigatusQ37422080
Ustilago maydis, model system for analysis of the molecular basis of fungal pathogenicityQ37766639
DNA array studies demonstrate convergent regulation of virulence factors by Cph1, Cph2, and Efg1 in Candida albicansQ38295895
The G-protein beta subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformansQ39450229
Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screeningQ39601355
Osmoregulation and fungicide resistance: the Neurospora crassa os-2 gene encodes a HOG1 mitogen-activated protein kinase homologueQ39649957
ras2 Controls morphogenesis, pheromone response, and pathogenicity in the fungal pathogen Ustilago maydisQ39692275
The Hog1 mitogen-activated protein kinase is essential in the oxidative stress response and chlamydospore formation in Candida albicans.Q39751926
An unusual MAP kinase is required for efficient penetration of the plant surface by Ustilago maydisQ39756383
Guanyl nucleotide exchange factor Sql2 and Ras2 regulate filamentous growth in Ustilago maydisQ39774488
The Sho1 adaptor protein links oxidative stress to morphogenesis and cell wall biosynthesis in the fungal pathogen Candida albicans.Q39890876
The Fusarium graminearum MAP1 gene is essential for pathogenicity and development of peritheciaQ39938707
Functional characterization of the MKC1 gene of Candida albicans, which encodes a mitogen-activated protein kinase homolog related to cell integrityQ40016068
PKA and MAPK phosphorylation of Prf1 allows promoter discrimination in Ustilago maydisQ40240145
Cell wall integrity is dependent on the PKC1 signal transduction pathway in Cryptococcus neoformans.Q40384960
Mating and pathogenic development of the Smut fungus Ustilago maydis are regulated by one mitogen-activated protein kinase cascade.Q40495202
Fusarium oxysporum as a multihost model for the genetic dissection of fungal virulence in plants and mammalsQ40634702
Attenuation of the activity of caspofungin at high concentrations against candida albicans: possible role of cell wall integrity and calcineurin pathways.Q40668367
The Gbeta-subunit-encoding gene bpp1 controls cyclic-AMP signaling in Ustilago maydisQ40902857
The high-mobility-group domain transcription factor Rop1 is a direct regulator of prf1 in Ustilago maydisQ41095867
The Cek1 and Hog1 mitogen-activated protein kinases play complementary roles in cell wall biogenesis and chlamydospore formation in the fungal pathogen Candida albicans.Q41869795
BcSAK1, a stress-activated mitogen-activated protein kinase, is involved in vegetative differentiation and pathogenicity in Botrytis cinereaQ42180526
A mitogen-activated protein kinase pathway modulates the expression of two cellulase genes in Cochliobolus heterostrophus during plant infection.Q42439156
Two mitogen-activated protein kinase signalling cascades mediate basal resistance to antifungal plant defensins in Fusarium graminearum.Q42507405
Ras1 and Ras2 contribute shared and unique roles in physiology and virulence of Cryptococcus neoformansQ42667297
The Slt2-type MAP kinase Bmp3 of Botrytis cinerea is required for normal saprotrophic growth, conidiation, plant surface sensing and host tissue colonizationQ43052612
The MAP kinase-encoding gene MgFus3 of the non-appressorium phytopathogen Mycosphaerella graminicola is required for penetration and in vitro pycnidia formation.Q43052644
Different signalling pathways involving a Galpha protein, cAMP and a MAP kinase control germination of Botrytis cinerea conidia.Q43433523
A MAP kinase of the vascular wilt fungus Fusarium oxysporum is essential for root penetration and pathogenesisQ43544096
Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus Candida albicansQ43808791
Mitogen-activated protein kinase Mkp1 of Pneumocystis carinii complements the slt2Delta defect in the cell integrity pathway of Saccharomyces cerevisiaeQ43880922
The mitogen-activated protein kinase gene MAF1 is essential for the early differentiation phase of appressorium formation in Colletotrichum lagenariumQ44021360
A mitogen-activated protein kinase gene (MGV1) in Fusarium graminearum is required for female fertility, heterokaryon formation, and plant infection.Q44210004
Mating, conidiation and pathogenicity of Fusarium graminearum, the main causal agent of the head-blight disease of wheat, are regulated by the MAP kinase gpmk1.Q44403848
Evidence that the appressorial development in barley powdery mildew is controlled by MAP kinase activity in conjunction with the cAMP pathwayQ44437596
The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformansQ44795443
Lipid-induced filamentous growth in Ustilago maydisQ44854375
P433issue10
P304page(s)1701-1714
P577publication date2007-08-22
P1433published inEukaryotic CellQ5408685
P1476titleMitogen-activated protein kinase pathways and fungal pathogenesis
P478volume6