Evidence against resveratrol as a viable therapy for the rescue of defective ΔF508 CFTR.

scientific article

Evidence against resveratrol as a viable therapy for the rescue of defective ΔF508 CFTR. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BBAGEN.2015.08.020
P932PMC publication ID4587346
P698PubMed publication ID26342647
P5875ResearchGate publication ID281540640

P2093author name stringNeil A Bradbury
Robert J Bridges
Kalpit Shah
Ying Jai
P2860cites workAntagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1Q22001533
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterasesQ24608197
Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770Q24644303
Cystic fibrosis: a worldwide analysis of CFTR mutations--correlation with incidence data and application to screeningQ28217255
Aggresomes: a cellular response to misfolded proteinsQ28292275
Resveratrol enhances airway surface liquid depth in sinonasal epithelium by increasing cystic fibrosis transmembrane conductance regulator open probabilityQ28535395
Identification of resveratrol oligomers as inhibitors of cystic fibrosis transmembrane conductance regulator by high-throughput screening of natural products from chinese medicinal plantsQ28537590
Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activationQ30449378
Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidationQ31393490
A cystic fibrosis pancreatic adenocarcinoma cell lineQ33598519
Cystic fibrosis as a disease of misprocessing of the cystic fibrosis transmembrane conductance regulator glycoproteinQ33636276
Activation of the CFTR Cl- channel by trimethoxyflavone in vitro and in vivoQ33646466
Defects in processing and trafficking of the cystic fibrosis transmembrane conductance regulatorQ33865171
Relative expression of the human epithelial Na+ channel subunits in normal and cystic fibrosis airwaysQ72005770
The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmfulQ77584639
c-Cbl facilitates endocytosis and lysosomal degradation of cystic fibrosis transmembrane conductance regulator in human airway epithelial cellsQ34094432
Identification and validation of hits from high throughput screens for CFTR modulatorsQ34121837
Absorption of three wine-related polyphenols in three different matrices by healthy subjectsQ34173356
High absorption but very low bioavailability of oral resveratrol in humansQ34343815
Rescue of murine F508del CFTR activity in native intestine by low temperature and proteasome inhibitorsQ34532897
Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosisQ34748891
Resveratrol has salutary effects on mucociliary transport and inflammation in sinonasal epitheliumQ35000352
Resveratrol rescues cAMP-dependent anionic transport in the cystic fibrosis pancreatic cell line CFPAC1.Q35036202
Resveratrol increases F508del-CFTR dependent salivary secretion in cystic fibrosis mice.Q36063078
Inhibition of nitric oxide and inflammatory cytokines in LPS-stimulated murine macrophages by resveratrol, a potent proteasome inhibitorQ36086859
Proteasome protease mediated regulation of cytokine induction and inflammationQ36301130
Prolonged treatment of cells with genistein modulates the expression and function of the cystic fibrosis transmembrane conductance regulator.Q36510038
Antisense oligodeoxynucleotides to the cystic fibrosis transmembrane conductance regulator inhibit cAMP-activated but not calcium-activated chloride currentsQ37121365
Do you know the sex of your cells?Q37575237
Curcumin, resveratrol and flavonoids as anti-inflammatory, cyto- and DNA-protective dietary compoundsQ37630776
Bioavailability of resveratrolQ37831925
Transcription of cystic fibrosis transmembrane conductance regulator requires a CCAAT-like element for both basal and cAMP-mediated regulation.Q38288759
Potentiation of mutant CFTR Cl- channel currents by the naturally occurring stilbene compound resveratrolQ39038142
Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR-21 regulation of BCL-2 expressionQ39202824
Crosstalk between apoptosis and autophagy within the Beclin 1 interactomeQ39352440
BH3 mimetics activate multiple pro-autophagic pathwaysQ39565305
ΔF508 CFTR surface stability is regulated by DAB2 and CHIP-mediated ubiquitination in post-endocytic compartmentsQ39703906
Rescue of DeltaF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small moleculesQ40323738
The chemopreventive agent resveratrol stimulates cyclic AMP-dependent chloride secretion in vitroQ40390182
Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models.Q40530907
Curcumin, a major constituent of turmeric, corrects cystic fibrosis defectsQ40563465
A mutation in the cystic fibrosis transmembrane conductance regulator generates a novel internalization sequence and enhances endocytic ratesQ40677468
Characterization of PKA isoforms and kinase-dependent activation of chloride secretion in T84 cells.Q41020023
Peripheral protein quality control removes unfolded CFTR from the plasma membraneQ41111670
T84 cells: anion selectivity demonstrates expression of Cl- conductance affected in cystic fibrosisQ41637792
Resveratrol inhibits foam cell formation via NADPH oxidase 1- mediated reactive oxygen species and monocyte chemotactic protein-1.Q41837091
An improved method to obtain highly differentiated monolayers of human bronchial epithelial cellsQ42458062
Isoproterenol-induced desensitization of mucin release in isolated rat submandibular aciniQ42489240
Synonymous codon usage affects the expression of wild type and F508del CFTR.Q42558062
Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitiveQ42816994
Trans-resveratrol oral administration does not affect the enzymatic activities in rat small intestineQ44131935
Resveratrol activates adenylyl-cyclase in human breast cancer cells: a novel, estrogen receptor-independent cytostatic mechanism.Q44456385
Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating.Q44495355
Enhancer stimulation unmasks latent gene transfer after adenovirus-mediated gene delivery into human vascular smooth muscle cellsQ45879921
Biosynthesis and degradation of CFTR.Q45968383
Anti-inflammatory and anti-asthmatic effects of resveratrol, a polyphenolic stilbene, in a mouse model of allergic asthmaQ46137754
Role of CFTR in airway diseaseQ47606626
VX-809 and related corrector compounds exhibit secondary activity stabilizing active F508del-CFTR after its partial rescue to the cell surface.Q50670824
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)2377-2384
P577publication date2015-09-02
P1433published inBiochimica et Biophysica ActaQ864239
P1476titleEvidence against resveratrol as a viable therapy for the rescue of defective ΔF508 CFTR.
P478volume1850

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cites work (P2860)
Q57474833Calcium-induced chloride secretion is decreased by Resveratrol in ileal porcine tissue
Q28073063Cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectives
Q36790589Natural Compounds as Therapeutic Agents in the Treatment Cystic Fibrosis

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