Identification of drug modulators targeting gene-dosage disease CMT1A.

scientific article

Identification of drug modulators targeting gene-dosage disease CMT1A. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/CB300048D
P932PMC publication ID3401360
P698PubMed publication ID22530759

P50authorJohn SvarenQ37611432
P2093author name stringJames Inglese
Ryan MacArthur
Sung-Wook Jang
Camila Lopez-Anido
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PMP22 accumulation in aggresomes: implications for CMT1A pathologyQ41697207
P2X7-mediated increased intracellular calcium causes functional derangement in Schwann cells from rats with CMT1A neuropathyQ42455824
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Pathological adaptive responses of Schwann cells to endoplasmic reticulum stress in bortezomib‐induced peripheral neuropathyQ42911212
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Alterations in degradative pathways and protein aggregation in a neuropathy model based on PMP22 overexpressionQ81570572
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A specific mechanism for nonspecific activation in reporter-gene assaysQ33347807
Apparent activity in high-throughput screening: origins of compound-dependent assay interferenceQ33563613
Myelin synthesis in the peripheral nervous system.Q33869411
SOX10 directly modulates ERBB3 transcription via an intronic neural crest enhancerQ33932242
Ascorbic acid treatment corrects the phenotype of a mouse model of Charcot-Marie-Tooth diseaseQ33976802
Krox-20 controls myelination in the peripheral nervous systemQ34324119
Comparison of a new pmp22 transgenic mouse line with other mouse models and human patients with CMT1A.Q34713834
The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomicsQ34992596
Regulation of the PMP22 gene through an intronic enhancerQ35001004
Ascorbic acid in Charcot-Marie-Tooth disease type 1A (CMT-TRIAAL and CMT-TRAUK): a double-blind randomised trialQ35159258
Neuropharmacological mechanisms of capsaicin and related substancesQ35333748
Role of the AP-1 transcription factor c-Jun in developing, adult and injured brainQ36485148
c-Jun is a negative regulator of myelination.Q36660683
High-throughput screening assays for the identification of chemical probesQ36885398
Peripheral myelin protein 22 is regulated post-transcriptionally by miRNA-29aQ37268768
Gene copy number variation and common human diseaseQ37650988
Nrg1/ErbB signaling networks in Schwann cell development and myelinationQ37787450
Ascorbic acid inhibits PMP22 expression by reducing cAMP levels.Q40170570
The transcription factor Sox10 is a key regulator of peripheral glial development.Q40423560
P433issue7
P304page(s)1205-1213
P577publication date2012-05-02
P1433published inACS Chemical BiologyQ165583
P1476titleIdentification of drug modulators targeting gene-dosage disease CMT1A.
P478volume7

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cites work (P2860)
Q27012700A brief review of recent Charcot-Marie-Tooth research and priorities
Q41357926Caveats in the Established Understanding of CMT1A.
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Q27671683Firefly Luciferase in Chemical Biology: A Compendium of Inhibitors, Mechanistic Evaluation of Chemotypes, and Suggested Use As a Reporter
Q34576213Genome editing-enabled HTS assays expand drug target pathways for Charcot-Marie-tooth disease
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Q45222726PMP22 messenger RNA levels in skin biopsies: testing the effectiveness of a Charcot-Marie-Tooth 1A biomarker
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Q90504875Regulating PMP22 expression as a dosage sensitive neuropathy gene
Q57961452Regulation of the neuropathy-associated Pmp22 gene by a distal super-enhancer
Q37530126Tead1 regulates the expression of Peripheral Myelin Protein 22 during Schwann cell development
Q42443417The diadenosine homodinucleotide P18 improves in vitro myelination in experimental Charcot-Marie-Tooth type 1A.
Q35756877Thermodynamic Proxies to Compensate for Biases in Drug Discovery Methods

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