Cytokine-conditioned dendritic cells induce humoral tolerance to protein therapy in mice

scientific article

Cytokine-conditioned dendritic cells induce humoral tolerance to protein therapy in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1089/HUM.2011.225
P932PMC publication ID3404424
P698PubMed publication ID22468961

P2093author name stringBrendan Lee
Kilian Guse
Masataka Suzuki
John R Rodgers
Racel Cela
Gautam Sule
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Effect of B-cell depletion using anti-CD20 therapy on inhibitory antibody formation to human FVIII in hemophilia A miceQ34707338
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NOD2 signaling contributes to the innate immune response against helper-dependent adenovirus vectors independently of MyD88 in vivo.Q35226121
Suppression of the immune response to FVIII in hemophilia A mice by transgene modified tolerogenic dendritic cellsQ35285735
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Combined Administration of a Mutant TGF-β1/Fc and Rapamycin Promotes Induction of Regulatory T Cells and Islet Allograft ToleranceQ37155930
Dynamics of factor VIII interactions determine its immunologic fate in hemophilia A.Q37158890
Immune tolerance with rituximab in congenital haemophilia with inhibitors: a systematic literature review based on individual patients' analysisQ37232091
STAT6 activation confers upon T helper cells resistance to suppression by regulatory T cells.Q37369331
A cellular viewpoint of anti-FVIII immune response in hemophilia A.Q37376144
Factor VIII-pulsed dendritic cells reduce anti-factor VIII antibody formation in the hemophilia A mouse modelQ37423529
The molecular mechanisms of immunomodulation and tolerance induction to factor VIII.Q37543609
Memory CD4+ T cells do not induce graft-versus-host diseaseQ39778135
Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectorsQ40942254
Induction of tolerance to factor VIII by transient co-administration with rapamycin.Q41824863
Prophylactic immune tolerance induced by changing the ratio of antigen-specific effector to regulatory T cellsQ42362478
B-cell-delivered gene therapy induces functional T regulatory cells and leads to a loss of antigen-specific effector cellsQ42502298
Nonredundant roles of IL-10 and TGF-β in suppression of immune responses to hepatic AAV-factor IX gene transferQ42786561
Tolerogenic dendritic cells generated with different immunosuppressive cytokines induce antigen-specific anergy and regulatory properties in memory CD4+ T cells.Q43190647
Dendritic cell function after gene transfer with adenovirus-calcium phosphate co-precipitatesQ43555422
Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivoQ43687301
Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cellsQ44986020
Antigen-specific modulation of murine IgE and IgG2a responses with glutaraldehyde-polymerized allergen is independent of MHC haplotype and Igh allotypeQ45247106
Prevention and treatment of factor VIII inhibitors in murine hemophilia A.Q45865107
Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains.Q45868863
Induction of antigen-specific CD4+ T-cell anergy and deletion by in vivo viral gene transferQ45874902
Reduction of the immune response to factor VIII mediated through tolerogenic factor VIII presentation by immature dendritic cellsQ45880542
Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6.Q45998381
Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques.Q50946765
IL-10/TGF-beta-treated dendritic cells, pulsed with insulin, specifically reduce the response to insulin of CD4+ effector/memory T cells from type 1 diabetic individuals.Q51050539
In vivo induction of type 1-like regulatory T cells using genetically modified B cells confers long-term IL-10-dependent antigen-specific unresponsivenessQ56899837
CD4(+) and CD8(+) anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activityQ56904531
Induction of IL-10 producing CD4+ T cells with regulatory activities by stimulation with IL-10 gene-modified bone marrow derived dendritic cellsQ64376626
An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase constructQ72411299
Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapseQ73153290
Human peripheral blood monocyte-derived interleukin-10-induced semi-mature dendritic cells induce anergic CD4(+) and CD8(+) T cells via presentation of the internalized soluble antigen and cross-presentation of the phagocytosed necrotic cellular fraQ74684911
P433issue7
P921main subjectdendritic cellQ506253
P304page(s)769-780
P577publication date2012-05-11
P1433published inHuman Gene TherapyQ15757580
P1476titleCytokine-conditioned dendritic cells induce humoral tolerance to protein therapy in mice
P478volume23

Reverse relations

cites work (P2860)
Q39022950Approaches to Mitigate the Unwanted Immunogenicity of Therapeutic Proteins during Drug Development.
Q36928899Exposure to factor VIII protein in the presence of phosphatidylserine induces hypo-responsiveness toward factor VIII challenge in hemophilia A mice
Q43218590IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII.
Q90836400Immunogenicity of Protein Pharmaceuticals
Q52836537Peanut allergens are rapidly transferred in human breast milk and can prevent sensitization in mice.
Q38090391Progress toward inducing immunologic tolerance to factor VIII.
Q38308222Strategies for reducing inhibitor formation in severe haemophilia

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