In Vitro Investigation of Crosstalk between Fatty Acid and Polyketide Synthases in the Andrimid Biosynthetic Assembly Line.

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In Vitro Investigation of Crosstalk between Fatty Acid and Polyketide Synthases in the Andrimid Biosynthetic Assembly Line. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CBIC.201600410
P698PubMed publication ID27598417

P50authorHideaki KakeyaQ46096308
P2093author name stringFumihiro Ishikawa
Hiroyasu Sugimoto
P2860cites workCatalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylaseQ27640455
Trapping the dynamic acyl carrier protein in fatty acid biosynthesisQ27681033
An unusual buried polar cluster in a family of fungal lipasesQ27729837
Using modern tools to probe the structure-function relationship of fatty acid synthasesQ28080940
Fatty acid synthase, a proficient multifunctional enzymeQ28271458
MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolorQ28292215
The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for lifeQ28659329
Directed evolution can rapidly improve the activity of chimeric assembly-line enzymesQ33290356
Directed evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivoQ33910739
Polyketide and nonribosomal peptide antibiotics: modularity and versatilityQ33976771
Enzymes involved in fatty acid and polyketide biosynthesis in Streptomyces glaucescens: role of FabH and FabD and their acyl carrier protein specificityQ34144066
Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.Q34555236
Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesisQ34867101
Purification of a malonyltransferase from Streptomyces coelicolor A3(2) and analysis of its genetic determinantQ35589890
Structure-based analysis of the molecular interactions between acyltransferase and acyl carrier protein in vicenistatin biosynthesis.Q36607621
Structure and mechanism of the 6-deoxyerythronolide B synthaseQ36747462
Andrimid producers encode an acetyl-CoA carboxyltransferase subunit resistant to the action of the antibioticQ36869831
Gatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line.Q37310014
A biosynthetic gene cluster for the acetyl-CoA carboxylase inhibitor andrimidQ40297667
An orthogonal purification strategy for isolating crosslinked domains of modular synthasesQ40778863
Reconstitution of the FK228 biosynthetic pathway reveals cross talk between modular polyketide synthases and fatty acid synthaseQ41881191
Sulfonyl 3-alkynyl pantetheinamides as mechanism-based cross-linkers of acyl carrier protein dehydrataseQ42177217
Stereochemistry and mechanism of a microbial phenylalanine aminomutase.Q42740603
Synthesis and characterisation of acyl carrier protein bound polyketide analoguesQ43938782
Polyketide synthase acyl carrier protein (ACP) as a substrate and a catalyst for malonyl ACP biosynthesisQ44862677
Fluorescent multiplex analysis of carrier protein post-translational modification.Q46577030
Identification and characterization of the first class of potent bacterial acetyl-CoA carboxylase inhibitors with antibacterial activityQ47811083
Reconstitution of the iterative type II polyketide synthase for tetracenomycin F2 biosynthesisQ48019885
Malonyl-coenzyme A:acyl carrier protein acyltransferase of Streptomyces glaucescens: a possible link between fatty acid and polyketide biosynthesisQ48072027
A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines.Q50951357
P433issue22
P921main subjectfatty acidQ61476
P304page(s)2137-2142
P577publication date2016-10-11
P1433published inChemBioChemQ634395
P1476titleIn Vitro Investigation of Crosstalk between Fatty Acid and Polyketide Synthases in the Andrimid Biosynthetic Assembly Line
P478volume17

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cites work (P2860)
Q48103865A Chemoproteomics Approach to Investigate Phosphopantetheine Transferase Activity at the Cellular Level
Q47449403A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit.
Q48223572Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights.
Q90365236Discovery of 16-Demethylrifamycins by Removing the Predominant Polyketide Biosynthesis Pathway in Micromonospora sp. Strain TP-A0468

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