TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma: potential role of TRPM8 as a biomarker and target

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TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma: potential role of TRPM8 as a biomarker and target is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4161/CBT.20079
P932PMC publication ID3408969
P698PubMed publication ID22555807
P5875ResearchGate publication ID224897093

P50authorChris S JensenQ58396478
Robert D BrownQ84067688
P2093author name stringWeiqiang Zhou
Nelson S Yee
Rosemary K Yee
Henning Gerke
Min Sun Lee
P2860cites workCancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deathsQ28241157
A TRP channel that senses cold stimuli and mentholQ28511363
Identification of a cold receptor reveals a general role for TRP channels in thermosensationQ28580334
TRP channels as cellular sensorsQ29615917
Pancreatic cancerQ29616288
TRP channelsQ29616673
Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins.Q30666311
Estrogen regulation of TRPM8 expression in breast cancer cellsQ33581314
Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neuronsQ33903991
Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinomaQ34106466
TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH.Q34326212
Evidence that TRPM8 is an androgen-dependent Ca2+ channel required for the survival of prostate cancer cellsQ34368771
Werner syndrome as a hereditary risk factor for exocrine pancreatic cancer: potential role of WRN in pancreatic tumorigenesis and patient-tailored therapyQ34582178
Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancerQ34611784
Clinicopathologic and molecular features of pancreatic adenocarcinoma associated with Peutz-Jeghers syndromeQ35097837
Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.Q35166852
Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and functionQ35785718
Pathways of apoptotic and non-apoptotic death in tumour cellsQ35852309
TRPM8 in prostate cancer cells: a potential diagnostic and prognostic marker with a secretory function?Q36443022
Ion channels: functional expression and therapeutic potential in cancer. Colloquium on Ion Channels and CancerQ37152732
Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer.Q39855695
Androgen receptor blockade in experimental combination therapy of pancreatic cancerQ40121837
Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors.Q40167692
Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cellsQ40370834
Biophysical properties of menthol-activated cold receptor TRPM8 channelsQ40411029
Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5-bisphosphate.Q40457196
The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channelQ40516374
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channelsQ40526282
Ca2+ pools and cell growth. Evidence for sarcoendoplasmic Ca2+-ATPases 2B involvement in human prostate cancer cell growth controlQ43770504
Zebrafish as a model for pancreatic cancer research.Q44282968
PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domainQ46455727
Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement.Q46537728
Tissue distribution profiles of the human TRPM cation channel familyQ48495433
Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase CQ57979874
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectpancreatic adenocarcinomaQ18556189
biomarkerQ864574
P304page(s)592-599
P577publication date2012-06-01
P1433published inCancer Biology and TherapyQ2544651
P1476titleTRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma: potential role of TRPM8 as a biomarker and target
P478volume13

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cites work (P2860)
Q33883908Aberrantly Over-Expressed TRPM8 Channels in Pancreatic Adenocarcinoma: Correlation with Tumor Size/Stage and Requirement for Cancer Cells Invasion
Q42265978Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells
Q47833558Cutaneous Penetration-Enhancing Effect of Menthol: Calcium Involvement
Q38971352Ion channel TRPM8 promotes hypoxic growth of prostate cancer cells via an O2 -independent and RACK1-mediated mechanism of HIF-1α stabilization
Q42316196Ion channels in control of pancreatic stellate cell migration
Q37428766Knockdown of TRPM8 suppresses cancer malignancy and enhances epirubicin-induced apoptosis in human osteosarcoma cells
Q26777996Roles of TRPM8 Ion Channels in Cancer: Proliferation, Survival, and Invasion
Q57177412TRPC6 in simulated microgravity of intervertebral disc cells
Q37288109TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets
Q38709214TRPM8: a potential target for cancer treatment
Q26849317Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
Q28468696Translating discovery in zebrafish pancreatic development to human pancreatic cancer: biomarkers, targets, pathogenesis, and therapeutics

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