Methylation-dependent activation of CDX1 through NF-κB: a link from inflammation to intestinal metaplasia in the human stomach

scientific article

Methylation-dependent activation of CDX1 through NF-κB: a link from inflammation to intestinal metaplasia in the human stomach is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.AJPATH.2012.04.028
P932PMC publication ID3409443
P698PubMed publication ID22749770
P5875ResearchGate publication ID228101444

P50authorArndt HartmannQ89782316
Peter C KonturekQ112132198
Regine Schneider-StockQ51113253
P2093author name stringTilman T Rau
Andreas Jung
Regine Schneider-Stock
Wael El-Rifai
Arno Dimmler
Reinhard E Voll
Gerhard Faller
Bettina Sehnert
Anja Rogler
Myrjam Frischauf
P2860cites workCDX1 is an important molecular mediator of Barrett's metaplasiaQ24529062
Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell linesQ24597859
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The homeobox gene Cdx1 belongs to the p53-p21(WAF)-Bcl-2 network in intestinal epithelial cellsQ28203367
Risk of high-grade dysplasia or carcinoma in gastric biopsy-proven low-grade dysplasia: an analysis using the Vienna classification.Q51588236
Molecular and histological evaluation of tumor necrosis factor-alpha expression in Helicobacter pylori-mediated gastric carcinogenesis.Q53298641
Aberrant CpG island methylation in early-onset sporadic gastric carcinoma.Q53355715
Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas.Q53384678
CDX1 expression is reduced in colorectal carcinoma and is associated with promoter hypermethylation.Q54700906
CDX2promoter methylation is not associated with mRNA expressionQ58965609
Aberrant DNA Methylation in Non-Neoplastic Gastric Mucosa of H. Pylori Infected Patients and Effect of EradicationQ59348484
Gastric cancer occurrence in preneoplastic lesions: A long-term follow-up in a high-risk area in SpainQ60651515
Heat shock activation of NFkB in rat liver is mediated by interleukin-1Q71736261
Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic rasQ77931485
Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancerQ80973076
Roles of caudal-related homeobox gene Cdx1 in oesophageal epithelial cells in Barrett's epithelium developmentQ83172283
Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa BQ29618210
rVISTA 2.0: evolutionary analysis of transcription factor binding sitesQ31081582
Cdx1 promotes differentiation in a rat intestinal epithelial cell line.Q33882050
Promoter DNA hypermethylation in gastric biopsies from subjects at high and low risk for gastric cancerQ34047716
DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell linesQ34139601
The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development.Q34229849
Global DNA hypomethylation occurs in the early stages of intestinal type gastric carcinomaQ34410374
Histone acetylation: a switch between repressive and permissive chromatin. Second in review series on chromatin dynamics.Q34554335
DNA methylation status is inversely correlated with green tea intake and physical activity in gastric cancer patientsQ34930032
STAT3 complements defects in an interferon-resistant cell line: evidence for an essential role for STAT3 in interferon signaling and biological activitiesQ36091763
The homeodomain transcription factor Cdx1 does not behave as an oncogene in normal mouse intestineQ36405466
Differentiation of the gastric mucosa III. Animal models of oxyntic atrophy and metaplasiaQ36647595
The combined expression of metaplasia biomarkers predicts the prognosis of gastric cancerQ37448891
Helicobacter pylori infection in gastric cancerogenesis.Q37614116
Pathophysiology of intestinal metaplasia of the stomach: emphasis on CDX2 regulationQ37713792
Incidence of chronic atrophic gastritis: systematic review and meta-analysis of follow-up studiesQ37768375
The caudal-related homeodomain protein CDX1 activates proliferating cell nuclear antigen expression in hepatocellular and colorectal carcinoma cells.Q38293913
A human model of gastric carcinogenesis.Q39644851
Gastric cancer surveillance in a high-risk population in tuscany (Central Italy): preliminary results.Q39760422
CHFR, a potential tumor suppressor, downregulates interleukin-8 through the inhibition of NF-kappaB.Q39850171
Identification of genes epigenetically silenced by CpG methylation in human gastric carcinomaQ39887150
Methylation of protocadherin 10, a novel tumor suppressor, is associated with poor prognosis in patients with gastric cancer.Q39904868
Promoter methylation of the Wnt/beta-catenin signaling antagonist Dkk-3 is associated with poor survival in gastric cancerQ39909656
Bile acids induce overexpression of homeobox gene CDX-2 and vascular endothelial growth factor (VEGF) in human Barrett's esophageal mucosa and adenocarcinoma cell line.Q40081597
Evidence for acid-induced loss of Cdx2 expression in duodenal gastric metaplasiaQ40534240
Cdx1 or Cdx2 expression activates E-cadherin-mediated cell-cell adhesion and compaction in human COLO 205 cellsQ40587288
Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinomaQ40589141
Transcription of sonic hedgehog, a potential factor for gastric morphogenesis and gastric mucosa maintenance, is up-regulated in acidic conditionsQ40604746
Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines.Q40629156
Cdx1 inhibits the proliferation of human colon cancer cells by reducing cyclin D1 gene expressionQ40631541
Stimulation of Cdx1 by oncogenic beta-catenin/Tcf4 in colon cancer cells; opposite effect of the CDX2 homeoproteinQ40733634
Cdx1 promotes cellular growth of epithelial intestinal cells through induction of the secretory protein PAP I.Q40812814
Wnt/(beta)-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine.Q40863107
H3 lysine 4 di- and tri-methylation deposited by cryptic transcription attenuates promoter activationQ41313602
Global hypomethylation of genomic DNA in cancer-associated myofibroblasts.Q41811062
Cdx1 induced intestinal metaplasia in the transgenic mouse stomach: comparative study with Cdx2 transgenic miceQ42071066
CDX1 protein expression in normal, metaplastic, and neoplastic human alimentary tract epitheliumQ42798173
Ten-year prospective follow-up of histological changes at five points on the gastric mucosa as recommended by the updated Sydney system after Helicobacter pylori eradicationQ43581382
PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathwayQ44165168
Transgenic Cdx2 induces endogenous Cdx1 in intestinal metaplasia of Cdx2-transgenic mouse stomachQ44993621
CB1 cannabinoid receptors are involved in neuroprotection via NF-kappa B inhibitionQ45281373
E-cadherin deficiency initiates gastric signet-ring cell carcinoma in mice and man.Q46119136
Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors.Q46814293
Risk factors for progression to gastric neoplastic lesions in patients with atrophic gastritis.Q51141736
Detection of p16 hypermethylation in gastric carcinomas using a seminested methylation-specific PCR.Q51487557
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P304page(s)487-498
P577publication date2012-06-27
P1433published inThe American Journal of PathologyQ4744259
P1476titleMethylation-dependent activation of CDX1 through NF-κB: a link from inflammation to intestinal metaplasia in the human stomach
P478volume181

Reverse relations

cites work (P2860)
Q46124630Chronic Kidney Disease Induces Inflammatory CD40+ Monocyte Differentiation via Homocysteine Elevation and DNA Hypomethylation
Q53257548Death-associated protein kinase controls STAT3 activity in intestinal epithelial cells.
Q42059456Epigenetic modifications and NF-κB pathway activity in Cu,Zn-SOD-deficient mice
Q53082211IL-32 gamma reduces lung tumor development through upregulation of TIMP-3 overexpression and hypomethylation.
Q37397682Large deletions encompassing the TCOF1 and CAMK2A genes are responsible for Treacher Collins syndrome with intellectual disability
Q39495585Quantitative leukocyte BDNF promoter methylation analysis in bipolar disorder
Q33703901Synbindin in extracellular signal-regulated protein kinase spatial regulation and gastric cancer aggressiveness
Q38307191Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.
Q53026586[Pathogenetic aspects in precursor lesions of gastrointestinal tumors].
Q33688891hTERT promotes gastric intestinal metaplasia by upregulating CDX2 via NF-κB signaling pathway

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