The therapeutic potential of mitochondrial channels in cancer, ischemia-reperfusion injury, and neurodegeneration

scientific article

The therapeutic potential of mitochondrial channels in cancer, ischemia-reperfusion injury, and neurodegeneration is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/J.MITO.2011.03.003
P932PMC publication ID3410559
P698PubMed publication ID21406252
P5875ResearchGate publication ID50398301

P2093author name stringKathleen W Kinnally
Pablo M Peixoto
Laurent M Dejean
P2860cites workBcl-2 family interaction with the mitochondrial morphogenesis machineryQ24293601
Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosisQ24307662
A novel X-linked gene, DDP, shows mutations in families with deafness (DFN-1), dystonia, mental deficiency and blindnessQ24311730
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family membersQ24337108
Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channelQ24523479
Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosisQ24533270
Microsecond time-scale discrimination among polycytidylic acid, polyadenylic acid, and polyuridylic acid as homopolymers or as segments within single RNA moleculesQ24537315
A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeastQ24685400
Solution Structure of the Integral Human Membrane Protein VDAC-1 in Detergent MicellesQ27651854
Structure of the human voltage-dependent anion channelQ27652383
The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gatingQ27652797
The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membraneQ27931625
Active remodelling of the TIM23 complex during translocation of preproteins into mitochondriaQ27932754
Import of carrier proteins into the mitochondrial inner membrane mediated by Tim22.Q27933337
Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channelQ27935135
Pam17 is required for architecture and translocation activity of the mitochondrial protein import motorQ27935671
Role of Tim21 in mitochondrial translocation contact sitesQ27936374
Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17.Q27936577
Cyclosporin inhibits mitochondrial calcium efflux in isolated adult rat ventricular cardiomyocytesQ28187564
The Ca2+-induced membrane transition in mitochondria. III. Transitional Ca2+ releaseQ28211160
Mitochondrial permeability transition in acute neurodegenerationQ28218571
The ADP/ATP translocator is not essential for the mitochondrial permeability transition poreQ28241418
Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell deathQ28242641
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell deathQ28242653
Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinasesQ28261309
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell deathQ28297152
The Ca2+-induced membrane transition in mitochondria. I. The protective mechanismsQ28305411
The Ca2+-induced membrane transition in mitochondria. II. Nature of the Ca2+ trigger siteQ28306067
Control of mitochondrial apoptosis by the Bcl-2 familyQ37385623
Mitochondrial calcium function and dysfunction in the central nervous systemQ37418288
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's diseaseQ37463481
Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases.Q37466088
MAC and Bcl-2 family proteins conspire in a deadly plotQ37677213
Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channelsQ37680210
Signal transduction to the permeability transition pore.Q37691823
VDAC, a multi-functional mitochondrial protein regulating cell life and deathQ37719811
Role of mitochondrial ion channels in cell deathQ37771917
Mitochondrial protein import: from proteomics to functional mechanismsQ37781692
Mechanisms by which mitochondria transport calciumQ37920440
Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.Q38268983
BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death programQ38269004
Phosphorothioate oligonucleotides block the VDAC channelQ38302060
Calcium signaling and neurodegenerative diseasesQ39463322
The nuclear receptor interacting factor-3 transcriptional coregulator mediates rapid apoptosis in breast cancer cells through direct and bystander-mediated eventsQ40169586
The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan.Q40178770
Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia.Q40355180
Targeting apoptosis via chemical design: inhibition of bid-induced cell death by small organic molecules.Q40523260
Some amphiphilic cations block the mitochondrial apoptosis-induced channel, MAC.Q40545426
Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c releaseQ40551652
The permeability transition pore signals apoptosis by directing Bax translocation and multimerization.Q40741871
A peptide-sensitive channel of large conductance is localized on mitochondrial outer membraneQ41138468
Characterization and function of the mitochondrial outer membrane peptide-sensitive channelQ41456643
Perspectives on the mitochondrial multiple conductance channelQ41456650
VDAC closure increases calcium ion fluxQ41816375
Mitochondrial channel activity studied by patch-clamping mitoplastsQ42014495
Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondriaQ28507255
Bax inserts into the mitochondrial outer membrane by different mechanismsQ28567499
In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell deathQ28576382
Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemiaQ28585666
Role of Bax and Bak in mitochondrial morphogenesisQ28591724
VDAC2 inhibits BAK activation and mitochondrial apoptosisQ28594000
Mitochondrial membrane permeabilization in cell deathQ29547425
An inhibitor of Bcl-2 family proteins induces regression of solid tumoursQ29547595
The mitochondrial permeability transition pore and its role in cell deathQ29614183
Mitochondrial respiratory-chain diseasesQ29614474
Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseasesQ29615646
Importing mitochondrial proteins: machineries and mechanismsQ29616477
Translocation of proteins into mitochondriaQ29616478
Mitochondrial dynamics and apoptosisQ29616570
Hunting interactomes of a membrane protein: obtaining the largest set of voltage-dependent anion channel-interacting protein epitopes.Q30354657
Mitochondrial apoptosis is amplified through gap junctionsQ30491150
Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respirationQ33346359
Mitochondrial ion channels as therapeutic targetsQ33857921
VDAC channels mediate and gate the flow of ATP: implications for the regulation of mitochondrial functionQ33915365
MitoP2, an integrated database on mitochondrial proteins in yeast and manQ33974660
Properties of the mitochondrial peptide-sensitive cationic channel studied in planar bilayers and patches of giant liposomesQ34091557
Mitochondrial shape changes: orchestrating cell pathophysiology.Q34106103
Reversible and irreversible effects of basic peptides on the mitochondrial cationic channelQ34115419
Old players in a new role: mitochondria-associated membranes, VDAC, and ryanodine receptors as contributors to calcium signal propagation from endoplasmic reticulum to the mitochondriaQ34172299
Transport of maltodextrins through maltoporin: a single-channel studyQ34177184
Comparison of the TIM and TOM Channel Activities of the Mitochondrial Protein Import ComplexesQ34181068
Therapeutic prospects for mitochondrial diseaseQ34205124
Effects of cytochrome c on the mitochondrial apoptosis-induced channel MAC.Q34312305
Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.Q34406704
Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia.Q34458933
MCC and PSC, the putative protein import channels of mitochondriaQ34478958
Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt.Q34487811
Is MAC the knife that cuts cytochrome c from mitochondria during apoptosis?Q34522154
Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.Q34562025
RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channelsQ34618715
Hydrogen peroxide sensing and signalingQ34619087
Reconstitution in planar lipid bilayers of a voltage-dependent anion-selective channel obtained from paramecium mitochondriaQ42597073
The mitochondrial megachannel is the permeability transition poreQ44175602
3,6-Dibromocarbazole Piperazine Derivatives of 2-Propanol as First Inhibitors of Cytochrome c Release via Bax Channel ModulationQ44604105
Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemiaQ46247309
Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2.Q46499587
Methyl jasmonate binds to and detaches mitochondria-bound hexokinaseQ46647628
Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell deathQ46839351
Fatal acute lymphoblastic leukemia in mice transgenic for B cell-restricted bcl-xL and c-myc.Q47579113
The preprotein translocation channel of the outer membrane of mitochondriaQ47945539
Mitochondrial oxidative stress and cell death in astrocytes--requirement for stored Ca2+ and sustained opening of the permeability transition poreQ48666655
Ca2+-dependent control of the permeability properties of the mitochondrial outer membrane and voltage-dependent anion-selective channel (VDAC).Q50113362
Novel cobalt complex inhibitors of mitochondrial calcium uptake.Q52536746
Novel murine B-cell lymphoma/leukemia model to study BCL2-driven oncogenesis.Q53361793
Bid, but not Bax, regulates VDAC channels.Q53849605
Mitochondria Are Excitable Organelles Capable of Generating and Conveying Electrical and Calcium SignalsQ53967833
The mitochondrial outer membrane channel, VDAC, is regulated by a synthetic polyanion.Q54131150
Distribution of binding sequences for the mitochondrial import receptors Tom20, Tom22, and Tom70 in a presequence-carrying preprotein and a non-cleavable preprotein.Q54263321
VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasiaQ56963014
The permeability transition and BCL-2 family proteins in apoptosis: co-conspirators or independent agents?Q58454328
The isolated complex of the translocase of the outer membrane of mitochondria. Characterization of the cation-selective and voltage-gated preprotein-conducting poreQ63005427
The outer mitochondrial membrane channel, VDAC, is modulated by a protein localized in the intermembrane spaceQ63027298
Molecular design of the voltage-dependent, anion-selective channel in the mitochondrial outer membraneQ63027302
NADH regulates the gating of VDAC, the mitochondrial outer membrane channelQ63027309
The mitochondrial channel VDAC has a cation-selective open stateQ63027354
Single-particle approaches in the analysis of small 2D crystals of the mitochondrial channel VDACQ63027359
Modulation of the mitochondrial megachannel by divalent cations and protonsQ67895102
The role of pyridine dinucleotides in regulating the permeability of the mitochondrial outer membraneQ71742645
ATP flux is controlled by a voltage-gated channel from the mitochondrial outer membraneQ71763105
Solubilization and reconstitution of the mitochondrial peptide-sensitive channelQ72071444
Primary structure of the cytochrome c from the snapping turtle, Chelydra serpentinaQ72920679
Relationship between the peptide-sensitive channel and the mitochondrial outer membrane protein translocation machineryQ73084816
Overexpression of Bcl-2 suppresses the calcium activation of a mitochondrial megachannelQ73935936
Mitochondrial presequencesQ77207198
Modulation of cell calcium signals by mitochondriaQ77327608
Tim17p regulates the twin pore structure and voltage gating of the mitochondrial protein import complex TIM23Q79407665
Awaking TIM22, a dynamic ligand-gated channel for protein insertion in the mitochondrial inner membraneQ80226294
Mitochondrial deafnessQ80297869
Cardioprotective effects of BMS-180448, a prototype mitoK(ATP) channel opener, and the role of salvage kinases, in the rat model of global ischemia and reperfusion heart injuryQ80577265
A pharmacologic target of G3139 in melanoma cells may be the mitochondrial VDAC.Q34624645
Is mPTP the gatekeeper for necrosis, apoptosis, or both?Q34630758
What is the mitochondrial permeability transition pore?Q34658211
Mitochondrial apoptosis-induced channel (MAC) function triggers a Bax/Bak-dependent bystander effect.Q34760689
Cyclosporine A treatment for Ullrich congenital muscular dystrophy: a cellular study of mitochondrial dysfunction and its rescueQ34882389
MAC inhibitors suppress mitochondrial apoptosisQ34998219
The BCL-2 family reunionQ35568029
Adenine nucleotide translocator 1 deficiency increases resistance of mouse brain and neurons to excitotoxic insults.Q35632870
Outer mitochondrial membrane permeability can regulate coupled respiration and cell survivalQ35690379
Mitochondrial dysfunction and glutamate excitotoxicity studied in primary neuronal culturesQ35699506
Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury.Q35839931
Mitochondrial mechanisms of neural cell apoptosisQ35876358
Chopped, trapped or tacked--protein translocation into the IMS of mitochondriaQ36092045
Regulated targeting of BAX to mitochondria.Q36255507
On the role of VDAC in apoptosis: fact and fictionQ36259127
Tim23, a protein import component of the mitochondrial inner membrane, is required for normal activity of the multiple conductance channel, MCC.Q36273797
Calcium, mitochondria and oxidative stress in neuronal pathology. Novel aspects of an enduring themeQ36371649
The mitochondrial permeability transition from in vitro artifact to disease targetQ36464595
Bcl-2-family proteins and hematologic malignancies: history and future prospectsQ36508817
The role of mitochondria in inherited neurodegenerative diseasesQ36521932
The role of mitochondria in apoptosis*.Q36602674
The mitochondrial permeability transition in neurologic diseaseQ36775895
Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranesQ36799170
Superoxide flashes in single mitochondriaQ36900957
BCL-2 family proteins: critical checkpoints of apoptotic cell deathQ37038230
Diagnosing and exploiting cancer's addiction to blocks in apoptosisQ37059647
The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damageQ37079047
Assembly of the mitochondrial apoptosis-induced channel, MAC.Q37169502
Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agentsQ37243963
Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondriaQ37366855
Characteristics and possible functions of mitochondrial Ca(2+) transport mechanismsQ37375152
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectreperfusion injuryQ1413991
neurodegenerationQ1755122
P304page(s)14-23
P577publication date2011-03-23
P1433published inMitochondrionQ2122381
P1476titleThe therapeutic potential of mitochondrial channels in cancer, ischemia-reperfusion injury, and neurodegeneration
P478volume12