What have we learned from brucellosis in the mouse model?

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What have we learned from brucellosis in the mouse model? is …
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scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1025575188
P356DOI10.1186/1297-9716-43-29
P932PMC publication ID3410789
P698PubMed publication ID22500859
P5875ResearchGate publication ID224034688

P50authorMaría Jesús GrilloQ74214900
Edgardo MorenoQ96160450
P2093author name stringIgnacio Moriyón
José María Blasco
Jean Pierre Gorvel
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Evaluation of protection afforded by Brucella abortus and Brucella melitensis unmarked deletion mutants exhibiting different rates of clearance in BALB/c miceQ34721256
Brucella abortus RB51 induces protection in mice orally infected with the virulent strain B. abortus 2308.Q34932167
Establishment of systemic Brucella melitensis infection through the digestive tract requires urease, the type IV secretion system, and lipopolysaccharide O antigenQ34995443
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Comparison of immune responses and resistance to brucellosis in mice vaccinated with Brucella abortus 19 or RB51.Q35380623
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Interleukin-10 downregulates protective immunity to Brucella abortus.Q35396687
Endogenous interleukin-12 is involved in resistance to Brucella abortus infection.Q35401154
Lack of a role for natural killer cells in early control of Brucella abortus 2308 infections in miceQ35444624
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Rough vaccines in animal brucellosis: structural and genetic basis and present status.Q35751808
Poly(D,L-lactide-coglycolide) particles containing gentamicin: pharmacokinetics and pharmacodynamics in Brucella melitensis-infected miceQ35758804
Evaluation of the role of LcrV-Toll-like receptor 2-mediated immunomodulation in the virulence of Yersinia pestisQ35913680
Kinetics of placental colonization of mice inoculated intravenously with Brucella abortus at day 15 of pregnancyQ36090030
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BvrR/BvrS-controlled outer membrane proteins Omp3a and Omp3b are not essential for Brucella abortus virulenceQ36097211
Aerosol infection of BALB/c mice with Brucella melitensis and Brucella abortus and protective efficacy against aerosol challengeQ36097216
Development of structures and transport functions in the mouse placentaQ36124326
Role of Toll-like receptor 4 in induction of cell-mediated immunity and resistance to Brucella abortus infection in miceQ36228814
Recruitment of dendritic cells to pathological niches in inflamed liverQ36260655
THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCEQ36266578
Host immune responses to the intracellular bacteria Brucella: does the bacteria instruct the host to facilitate chronic infection?Q36752941
Brucellosis vaccines: assessment of Brucella melitensis lipopolysaccharide rough mutants defective in core and O-polysaccharide synthesis and exportQ36755736
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Protection against Brucella melitensis or Brucella abortus in mice with immunoglobulin G (IgG), IgA, and IgM monoclonal antibodies specific for a common epitope shared by the Brucella A and M smooth lipopolysaccharidesQ36954697
Prophylaxis or treatment of experimental brucellosis with interleukin-1Q36963615
Comparative protection of mice against virulent and attenuated strains of Brucella abortus by passive transfer of immune T cells or serumQ36976243
Influence of endotoxin-protein in immunoglobulin G isotype responses of mice to Brucella abortus lipopolysaccharide.Q37013941
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Nondividing but metabolically active gamma-irradiated Brucella melitensis is protective against virulent B. melitensis challenge in miceQ37410370
Pathogenesis of bovine brucellosis.Q37592524
An evolutionary strategy for a stealthy intracellular Brucella pathogenQ37846874
Nucleotide-binding oligomerization domain-1 and -2 play no role in controlling Brucella abortus infection in miceQ39725033
Host susceptibility to Brucella abortus infection is more pronounced in IFN-γ knockout than IL-12/β2-microglobulin double-deficient miceQ39802365
Interleukin-1 receptor-associated kinase 4 is essential for initial host control of Brucella abortus infectionQ40315170
Comparative study of gamma interferon production in mice immunized with outer membrane proteins and whole bacteria of Brucella abortus.Q40368172
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Brucella abortus nicotinamidase (PncA) contributes to its intracellular replication and infectivity in miceQ40534167
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Genomic island 2 is an unstable genetic element contributing to Brucella lipopolysaccharide spontaneous smooth-to-rough dissociationQ41430521
Development and characterization of mouse models of infection with aerosolized Brucella melitensis and Brucella suisQ41882903
Mice lacking components of adaptive immunity show increased Brucella abortus virB mutant colonizationQ41960724
Neurobrucellosis associated with syndrome of inappropriate antidiuretic hormone with resultant diabetes insipidus and hypothyroidism.Q41992813
CD8+ Type 1 CD44hi CD45 RBlo T lymphocytes control intracellular Brucella abortus infection as demonstrated in major histocompatibility complex class I‐ and class II‐deficient miceQ42479525
OBSERVATIONS ON THE INFECTION OF CHICK EMBRYOS WITH BACTERIUM TULARENSE, BRUCELLA, AND PASTEURELLA PESTIS.Q42812951
Partial protection against Brucella infection in mice by immunization with nonpathogenic alphaproteobacteria.Q42909254
A bile salt hydrolase of Brucella abortus contributes to the establishment of a successful infection through the oral route in miceQ42913659
MyD88, but not toll-like receptors 4 and 2, is required for efficient clearance of Brucella abortusQ42957064
Role of TLRs in Brucella mediated murine DC activation in vitro and clearance of pulmonary infection in vivoQ43230783
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DeltaznuADeltapurE Brucella abortus 2308 mutant as a live vaccine candidateQ43433173
T cell subsets in granulomatous inflammation and immunity to L. Monocytogenes and B. abortusQ43677566
Comparison of T cell cytokines in resistant and susceptible mice infected with virulent Brucella abortus strain 2308.Q43749108
Reactivation of a residual Brucella abortus 19 vaccine infection in mice by a virulent challenge or by injection of brucellin or of Brucella lipopolysaccharide.Q43839947
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Placental pathology of the pregnant mouse inoculated with Brucella abortus strain 2308.Q45094191
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The defect in the metabolism of erythritol of the Brucella abortus B19 vaccine strain is unrelated with its attenuated virulence in miceQ45259196
[Course of chronic brucellosis in mice is not improved by administration of a vaccinal antigen]Q71646267
Mother to young transmission of Brucella abortus infection in mouse modelQ71649152
Comparison of the efficacy of Brucella suis strain 2 and Brucella melitensis Rev. 1 live vaccines against a Brucella melitensis experimental infection in pregnant ewesQ71932258
Genetic factors involved in murine susceptibility to experimental brucellosisQ72051029
Brucella melitensis Rev-1 vaccine as a cause of human brucellosisQ72231940
Interleukin-6 production during chronic experimental infectionQ72568006
BALB/c mice infected with Brucella abortus express protracted polyclonal responses of both IgG2a and IgG3 isotypesQ72630533
Therapeutic effects of rifampin and erythromycin in experimental murine brucellosisQ73417690
Frequent exposure of mice to crude Brucella abortus proteins down-regulates immune responseQ73600943
Bacteriologic and histologic features in mice after intranasal inoculation of Brucella melitensisQ73690481
Growth of Brucella abortus in macrophages from resistant and susceptible mouse strainsQ74129593
Studies in the pathology and pathogenesis of experimental brucellosis. II. The formation of the hepatic granuloma and its evolutionQ75802937
Studies in the pathology and pathogenesis of experimental brucellosis. III. Investigations pertaining to the function of the spleenQ75895028
Immune control of Brucella abortus 2308 infections in BALB/c miceQ77369300
Brucellosis in VenezuelaQ78468241
Fundamentals of host immune response against Brucella abortus: what the mouse model has revealed about control of infectionQ78468297
Treatment of Brucella-susceptible mice with IL-12 increases primary and secondary immunityQ79447326
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Central role of MyD88-dependent dendritic cell maturation and proinflammatory cytokine production to control Brucella abortus infectionQ80455158
A study on the use of male animal models for developing a live vaccine for brucellosisQ81063069
Temporal analysis of pathogenic events in virulent and avirulent Brucella melitensis infectionsQ81192466
Regulated upon activation normal T-cell expressed and secreted (RANTES) contributes to abortion caused by Brucella abortus infection in pregnant miceQ81752341
B cell-deficient mice display markedly enhanced resistance to the intracellular bacterium Brucella abortusQ83750636
Epidemiological study of Brucellosis in cattle, immunized with Brucella abortus RB51 vaccine in endemic zonesQ83982821
CD4+CD25+ T regulatory cells limit effector T cells and favor the progression of brucellosis in BALB/c miceQ56771725
Increases of efficacy as vaccine against Brucella abortus infection in mice by simultaneous inoculation with avirulent smooth bvrS/bvrR and rough wbkA mutantsQ57040908
Brucella abortus nicotinamidase (PncA) contributes to its intracellular replication and infectivity in miceQ57360870
Protective Action of Monospecific Anti-Brucella Sera in MiceQ59027623
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Efficacy of several antibiotic combinations against Brucella melitensis Rev 1 experimental infection in BALB/c miceQ59276377
MyD88-Dependent Activation of B220-CD11b+LY-6C+ Dendritic Cells during Brucella melitensis InfectionQ59312649
Morphometric and Histopathologic Analysis of Lymphoid Depletion in Murine Spleens Following Infection with Brucella abortus strains 2308 or RB51 or an htrA Deletion MutantQ60121748
Reduced interleukin-18 secretion in Brucella abortus 2308-infected murine peritoneal macrophages and in spleen cells obtained from B. abortus 2308-infected miceQ61278515
Differential secretion of interleukin-12 (IL-12) subunits and heterodimeric IL-12p70 protein by CD-1 mice and murine macrophages in response to intracellular infection by Brucella abortusQ61278519
Experimental bovine brucellosis. 3. The vaginal excretion of Brucella abortus before and after parturitionQ67247812
Effect of polyadenine: polyuridine on brucellosis in conventional and congenitally athymic miceQ67278960
Polyadenylic acid-polyuridylic acid (poly A : U) and experimental murine brucellosis. I. Effect of single and double-stranded polynucleotides on Brucella abortus in vivo and in vitroQ67367969
Development of spleenic infection in the mouse following intravenous inoculation of various species of Brucella in smooth (S) or rough (R) phasesQ67512727
Studies of some biological activities of "brucella" endotoxin in normal and infected animals and the role of the hypersensitivity factorQ67683624
[Transformatinon normalizing the distribution of the number of Brucella organisms in the spleen of rats vaccinated intraperitoneally]Q67866388
Immunogenicity of Brucella-extracted and recombinant protein vaccines in CD-1 and BALB/c miceQ68354141
Brucella suis S2, brucella melitensis Rev. 1 and Brucella abortus S19 living vaccines: residual virulence and immunity induced against three Brucella species challenge strains in miceQ68367993
Comparative histopathology in BALB/c mice infected with virulent and attenuated strains of Brucella abortusQ68370283
Duration of strain 2308 infection and immunogenicity of Brucella abortus lipopolysaccharide in five strains of miceQ69186013
Immunologic, histopathologic, and bacteriologic responses of five strains of mice to Brucella abortus strain 2308Q69186019
Clinical categories of neurobrucellosis. A report on 19 casesQ69716388
T cell regulation of the thymus-independent antibody response to trinitrophenylated-Brucella abortus (TNP-BA)Q69860763
Protection conferred on mice by monoclonal antibodies directed against outer-membrane-protein antigens of BrucellaQ70130424
Pathogenesis of placentitis in the goat inoculated with Brucella abortus. I. Gross and histologic lesionsQ70296685
Serum- and cell-mediated immune protection of mouse placenta and fetus against a Brucella abortus challenge: expression of barrier effect of placentaQ70386323
Some aspects of experimental bovine brucellosisQ70390879
Virulence of Brucella: bacterial growth and decline in miceQ70398206
Evaluation of vaccines and of antigen therapy in a mouse model for Brucella ovisQ70545779
[Development of Brucella abortus, Brucella melitensis and Brucella and Brucella suis infection infection in mice to a chronic stage and cure]Q70585514
[Proposed general method of controlling the activity of brucella vaccines]Q70645216
Theoretical, practical and statistical basis for a general control method of activity for anti-Brucella vaccinesQ70645220
Effect of Brucella abortus transfer factor in preventing murine brucellosisQ70838122
Genetic factors involved in murine resistance to experimental brucellosisQ70960853
Antibiotic treatment induces an increase of the specific antibody levels in Brucella melitensis infected miceQ70972698
Penetration of antibiotics into human leukocytes and dermal suction blistersQ71083842
Inadequate azithromycin activity against Brucella melitensis in mice with acute or chronic infectionsQ71601786
Resistance and susceptibility of mice to bacterial infection. IV. Genetic and cellular basis of resistance to chronic infection with Brucella abortusQ71615333
In vivo and in vitro effects of monoclonal antibody to Ly antigens on immunity to infectionQ71628011
Serological follow-up of human brucellosis by measuring IgG antibodies to lipopolysaccharide and cytoplasmic proteins of Brucella speciesQ71644766
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectbrucellosisQ156050
BrucellaQ313358
MusQ39275
animal disease modelQ64732998
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)29
P577publication date2012-04-13
P1433published inVeterinary ResearchQ15761008
P1476titleWhat have we learned from brucellosis in the mouse model?
P478volume43

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