ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes

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ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.359489
P932PMC publication ID3410990
P698PubMed publication ID22707717
P5875ResearchGate publication ID227179332

P2093author name stringJudith Hellman
Kailin R Mesa
Fengyun Xu
Jennifer Lucero
Kevin Wilhelmsen
P2860cites workCrystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptideQ24294695
Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)Q24297420
Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimerQ24318972
Regulatory role of MEF2D in serum induction of the c-jun promoterQ24319672
BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2CQ24532869
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinasesQ24632768
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Gene Expression Omnibus: NCBI gene expression and hybridization array data repositoryQ27860523
Pattern recognition receptors and inflammationQ27861115
Big mitogen-activated kinase regulates multiple members of the MEF2 protein familyQ28137985
Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signalingQ28259810
Role of Krüppel-like transcription factors in endothelial biologyQ28307295
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptorsQ28511605
Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infectionQ28587620
Getting to the site of inflammation: the leukocyte adhesion cascade updatedQ29547271
Regulation and function of NF-kappaB transcription factors in the immune systemQ29616427
The pathophysiology and treatment of sepsisQ29619103
Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activationQ31135115
Standardization of real-time PCR gene expression data from independent biological replicatesQ31155611
The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophagesQ33525044
The importance of being flexible: the case of basic region leucine zipper transcriptional regulatorsQ33566030
Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2.Q33579223
Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleusQ33873104
Mechanisms and functions of p38 MAPK signalling.Q34125736
Intravascular immunity: the host-pathogen encounter in blood vessels.Q34977555
ERK5 and the regulation of endothelial cell function.Q35012587
The role of the endothelium in severe sepsis and multiple organ dysfunction syndromeQ35051545
Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil responseQ36240198
TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidaseQ36259614
Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivoQ36351797
KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activationQ36399199
IkappaB kinase complexes: gateways to NF-kappaB activation and transcriptionQ36637874
Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathwayQ36637883
The MEK/ERK cascade: from signaling specificity to diverse functionsQ36656631
Divergent roles of endothelial NF-kappaB in multiple organ injury and bacterial clearance in mouse models of sepsisQ36699748
Evolving functions of endothelial cells in inflammationQ36950913
Post-transcriptional control of cytokine productionQ37113415
TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificityQ37136130
Control of mRNA decay by phosphorylation of tristetraprolin.Q37164616
Harmful molecular mechanisms in sepsisQ37273299
Connexin43 phosphorylation: structural changes and biological effectsQ37421795
MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.Q37433320
Structural biology of the Toll-like receptor familyQ37872762
The essential roles of Toll-like receptor signaling pathways in sterile inflammatory diseases.Q37877818
Tumor necrosis factor alpha-induced E-selectin expression is activated by the nuclear factor-kappaB and c-JUN N-terminal kinase/p38 mitogen-activated protein kinase pathwaysQ38349161
Internalization of Staphylococcus aureus by endothelial cells induces apoptosis.Q39574086
ERK5/BMK1 is indispensable for optimal colony-stimulating factor 1 (CSF-1)-induced proliferation in macrophages in a Src-dependent fashion.Q40005436
Analysis of neutrophil chemotaxisQ40148170
Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers.Q40402637
Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophagesQ40688402
Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappa B activationQ40830691
Regulation of TNF expression by multiple mitogen-activated protein kinase pathwaysQ40875315
The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathwaysQ41041404
A rapid in vitro cytotoxicity assay for the detection of tumor necrosis factor on human BT-20 cellsQ41681881
The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.Q41850515
Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic functionQ42474496
Transcriptional regulation of tissue-specific genes by the ERK5 mitogen-activated protein kinaseQ42590095
Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathwayQ43691664
p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitmentQ43822750
Histamine induces Toll-like receptor 2 and 4 expression in endothelial cells and enhances sensitivity to Gram-positive and Gram-negative bacterial cell wall componentsQ45067683
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signalingQ46438489
Essential role of MAPK phosphatase-1 in the negative control of innate immune responsesQ46902216
Transcriptional regulation of the human toll-like receptor 2 gene in monocytes and macrophagesQ48303295
Activation of Toll-like receptor 2 impairs hypoxic pulmonary vasoconstriction in mice.Q48540868
Inhibition of vascular permeability factor/vascular endothelial growth factor-mediated angiogenesis by the Kruppel-like factor KLF2.Q50763581
The role of mitogen- and stress-activated protein kinase 1 and 2 in chronic skin inflammation in mice.Q54626083
Infection of human vascular endothelial cells with Staphylococcus aureus induces hyperadhesiveness for human monocytes and granulocytesQ71968347
Induction of TLR2 expression by inflammatory stimuli is required for endothelial cell responses to lipopeptidesQ81818978
Toll-like receptor 2/6 stimulation promotes angiogenesis via GM-CSF as a potential strategy for immune defense and tissue regenerationQ82430160
Chemical synthesis of bacterial lipoteichoic acids: an insight on its biological significanceQ83424758
P4510describes a project that usesImageJQ1659584
P433issue32
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
toll-like receptorQ408004
P304page(s)26478-26494
P577publication date2012-06-15
P1433published inJournal of Biological ChemistryQ867727
P1476titleERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes
P478volume287

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cites work (P2860)
Q37369392ERK5 kinase activity is dispensable for cellular immune response and proliferation
Q50864381Endothelial Cells.
Q38811965Extracellular histones reduce survival and angiogenic responses of late outgrowth progenitor and mature endothelial cells
Q41033728Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation
Q39063397Flow signaling and atherosclerosis
Q49712215Identification of potential target genes for ankylosing spondylitis treatment
Q42681148LRRK2: dropping (kinase) inhibitions and seeking an (immune) response
Q53698113Linkage of Infection to Adverse Systemic Complications: Periodontal Disease, Toll-Like Receptors, and Other Pattern Recognition Systems.
Q27865268Mitogen-activated protein kinases in innate immunity
Q90316389Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors
Q42263195Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1.
Q41876141Quantitative in vitro assay to measure neutrophil adhesion to activated primary human microvascular endothelial cells under static conditions
Q41884603Systemic inflammation as a predictor of clinical outcomes after lower extremity angioplasty/stenting
Q28236199The endocannabinoid/endovanilloid N-arachidonoyl dopamine (NADA) and synthetic cannabinoid WIN55,212-2 abate the inflammatory activation of human endothelial cells
Q53687316Toll-like receptors in immunity and inflammatory diseases: Past, present, and future.
Q98771780When Innate Immunity Meets Angiogenesis-The Role of Toll-Like Receptors in Endothelial Cells and Pulmonary Hypertension

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