Retargeting transposon insertions by the adeno-associated virus Rep protein.

scientific article

Retargeting transposon insertions by the adeno-associated virus Rep protein. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKS317
P932PMC publication ID3413126
P698PubMed publication ID22523082
P5875ResearchGate publication ID224811587

P50authorZsuzsanna IzsvákQ21264884
Wei ChenQ30504047
Zoltán IvicsQ62559996
Andreas Gogol-DöringQ84472583
Toni CathomenQ37840253
P2093author name stringCsaba Miskey
Ismahen Ammar
P2860cites workUltrafast and memory-efficient alignment of short DNA sequences to the human genomeQ21183894
Model-based analysis of ChIP-Seq (MACS)Q21183902
Site-specific integration by adeno-associated virusQ24558738
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Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon systemQ24631198
Acquisition of Host Cell DNA Sequences by Baculoviruses: Relationship Between Host DNA Insertions and FP Mutants of Autographa californica and Galleria mellonella Nuclear Polyhedrosis VirusesQ24644862
Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domainsQ24655087
Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genesQ24657906
Prolonged expression of a lysosomal enzyme in mouse liver after Sleeping Beauty transposon-mediated gene delivery: implications for non-viral gene therapy of mucopolysaccharidosesQ24684749
Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferencesQ24798872
High-resolution profiling of histone methylations in the human genomeQ27860906
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genomeQ28131828
Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebratesQ28243550
Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1Q28290118
High-resolution genome-wide mapping of transposon integration in mammalsQ28769896
Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cellsQ29617246
Transcription start regions in the human genome are favored targets for MLV integrationQ29618456
HIV-1 integration in the human genome favors active genes and local hotspotsQ29618457
Site-specific integration of adeno-associated virus involves partial duplication of the target locus.Q30487078
Stem-cell gene therapy for the Wiskott-Aldrich syndromeQ33392766
Integration preferences of wildtype AAV-2 for consensus rep-binding sites at numerous loci in the human genomeQ33632181
Adeno-associated viral vectors for gene transfer and gene therapyQ33701559
LEDGF hybrids efficiently retarget lentiviral integration into heterochromatinQ33731166
A chimeric protein containing the N terminus of the adeno-associated virus Rep protein recognizes its target site in an in vivo assayQ33799084
How adeno-associated virus Rep78 protein arrests cells completely in S phaseQ34015943
Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous diseaseQ34094502
Involvement of a bifunctional, paired-like DNA-binding domain and a transpositional enhancer in Sleeping Beauty transpositionQ34135093
A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19.Q34156171
Gene transfer efficiency and genome-wide integration profiling of Sleeping Beauty, Tol2, and piggyBac transposons in human primary T cellsQ34183381
Hyperactive sleeping beauty transposase enables persistent phenotypic correction in mice and a canine model for hemophilia B.Q34343757
Tn7: smarter than we thoughtQ34443592
Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trialQ34640765
Use of the piggyBac transposon for germ-line transformation of insectsQ34843379
piggyBac is a flexible and highly active transposon as compared to sleeping beauty, Tol2, and Mos1 in mammalian cellsQ35108048
Comparative genomic integration profiling of Sleeping Beauty transposons mobilized with high efficacy from integrase-defective lentiviral vectors in primary human cellsQ35144439
Identification of a functional transposase of the Tol2 element, an Ac-like element from the Japanese medaka fish, and its transposition in the zebrafish germ lineageQ35290320
Chance or necessity? Insertional mutagenesis in gene therapy and its consequencesQ35637501
Adeno-associated virus vectors preferentially transduce cells in S phase.Q35754006
Site-directed transposon integration in human cellsQ35804718
Site-specific integration by adeno-associated virus is directed by a cellular DNA sequenceQ35829692
Sequence requirements for binding of Rep68 to the adeno-associated virus terminal repeatsQ35856414
Binding sites for adeno-associated virus Rep proteins within the human genome.Q35879908
Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virusQ36159178
Tol2: a versatile gene transfer vector in vertebratesQ36187507
Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity.Q36311669
Interaction of the adeno-associated virus Rep protein with a sequence within the A palindrome of the viral terminal repeat.Q36624790
Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty systemQ36713904
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patientsQ36812729
Healing the wounds inflicted by sleeping beauty transposition by double-strand break repair in mammalian somatic cells.Q51829783
Transposition and targeting of the prokaryotic mobile element IS30 in zebrafish.Q54519665
An engineered four-stranded coiled coil substitutes for the tetramerization domain of wild-type p53 and alleviates transdominant inhibition by tumor-derived p53 mutantsQ70866376
Altering the insertional specificity of a Drosophila transposable elementQ36869160
Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor bindingQ36995336
Targeted gene insertion for molecular medicineQ37209562
Nanocapsule-delivered Sleeping Beauty mediates therapeutic Factor VIII expression in liver sinusoidal endothelial cells of hemophilia A miceQ37241328
Retroviral Vectors for Gene TherapyQ37809064
Modulating target site selection during human immunodeficiency virus DNA integration in vitro with an engineered tethering factorQ38309659
Site-specific integration of a transgene mediated by a hybrid adenovirus/adeno-associated virus vector using the Cre/loxP-expression-switching systemQ38310905
Targeted Sleeping Beauty transposition in human cellsQ38480971
Manipulating piggyBac transposon chromosomal integration site selection in human cellsQ38585848
Precise targeted integration by a chimaeric transposase zinc-finger fusion protein.Q39373164
Targeting of the yeast Ty5 retrotransposon to silent chromatin is mediated by interactions between integrase and Sir4pQ39528168
Adeno-associated virus as a vector for liver-directed gene therapy.Q39583470
Sustained FVIII expression and phenotypic correction of hemophilia A in neonatal mice using an endothelial-targeted sleeping beauty transposonQ40319528
A role for LEDGF/p75 in targeting HIV DNA integrationQ40346940
Efficient transposition of the piggyBac (PB) transposon in mammalian cells and miceQ40386192
Sleeping Beauty-mediated down-regulation of huntingtin expression by RNA interference.Q40452758
Site-specific integration of functional transgenes into the human genome by adeno/AAV hybrid vectors.Q40510442
AAV serotype 2 vectors preferentially integrate into active genes in miceQ40643545
Adeno-associated virus: integration at a specific chromosomal locusQ40852243
Precise excision of TTAA-specific lepidopteran transposons piggyBac (IFP2) and tagalong (TFP3) from the baculovirus genome in cell lines from two species of LepidopteraQ41201975
Adeno-associated virus vector gene expression occurs in nondividing cells in the absence of vector DNA integrationQ41431346
Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon systemQ41734970
Insulin expression in livers of diabetic mice mediated by hydrodynamics-based administrationQ41848708
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brainQ42280576
In vivo correction of murine tyrosinemia type I by DNA-mediated transposition.Q44260023
RAC reviews serious adverse event associated with AAV therapy trialQ44304216
CD8(+) T-cell responses to adeno-associated virus capsid in humansQ45406111
Common physical properties of DNA affecting target site selection of sleeping beauty and other Tc1/mariner transposable elements.Q45855517
High-resolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR).Q45873348
Targeted integration of foreign DNA into a defined locus on chromosome 19 in K562 cells using AAV-derived componentsQ45879173
Phenotypic correction and long-term expression of factor VIII in hemophilic mice by immunotolerization and nonviral gene transfer using the Sleeping Beauty transposon systemQ45879828
Target-site preferences of Sleeping Beauty transposons.Q45880767
Combinatorial antiangiogenic gene therapy by nonviral gene transfer using the sleeping beauty transposon causes tumor regression and improves survival in mice bearing intracranial human glioblastomaQ45886735
Requirement of RNA polymerase III transcription factors for in vitro position-specific integration of a retroviruslike elementQ46798246
Stable nonviral genetic correction of inherited human skin diseaseQ46930709
Insertion of a novel transposable element in the tyrosinase gene is responsible for an albino mutation in the medaka fish, Oryzias latipesQ48068575
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P433issue14
P407language of work or nameEnglishQ1860
P304page(s)6693-6712
P577publication date2012-04-19
P1433published inNucleic Acids ResearchQ135122
P1476titleRetargeting transposon insertions by the adeno-associated virus Rep protein
P478volume40

Reverse relations

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