Programmed disorders of beta-cell development and function as one cause for type 2 diabetes? The GK rat paradigm

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Programmed disorders of beta-cell development and function as one cause for type 2 diabetes? The GK rat paradigm is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/DMRR.566
P698PubMed publication ID15926190

P2093author name stringBernard Portha
P2860cites workGenomic imprinting and epigenetic reprogramming: unearthing the garden of forking pathsQ28202464
The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and manQ28207622
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Gestational diabetes leads to the development of diabetes in adulthood in the rat.Q34125696
Metabolic programming: causes and consequencesQ34430909
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Diabetes mellitus and genetically programmed defects in beta-cell functionQ34462316
Mitochondrial function in normal and diabetic beta-cellsQ34462332
Genetic approaches to the molecular understanding of type 2 diabetesQ34731596
For debate: Fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure.Q35162950
Impaired pancreatic beta cell function in the fetal GK rat. Impact of diabetic inheritanceQ37378354
Maternal diabetes during pregnancy: consequences for the offspring.Q37797291
Mutations in the promoter of adenylyl cyclase (AC)-III gene, overexpression of AC-III mRNA, and enhanced cAMP generation in islets from the spontaneously diabetic GK rat model of type 2 diabetesQ38338987
Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK ratsQ40859035
Maternally inherited diabetes and deafness: a new diabetes subtypeQ41088487
Impaired development of pancreatic beta-cell mass is a primary event during the progression to diabetes in the GK rat.Q42443185
Beta-cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetesQ42475849
Defective glucose-dependent cytosolic Ca2+ handling in islets of GK and nSTZ rat models of type 2 diabetesQ42501182
beta-cell function and viability in the spontaneously diabetic GK rat: information from the GK/Par colonyQ42501772
Zinc depletion reduced Egr-1 and HNF-3beta expression and apolipoprotein A-I promoter activity in Hep G2 cellsQ42523430
Hyperglycemia contributes to impaired insulin response in GK rat isletsQ43555575
Impaired pancreatic duct-cell growth in focal areas of regeneration after partial pancreatectomy in the adult Goto-Kakizaki rat, a spontaneous model of non-insulin dependent diabetes mellitusQ43709102
Impaired beta-cell regeneration after partial pancreatectomy in the adult Goto-Kakizaki rat, a spontaneous model of type II diabetesQ43783938
Phenotyping of individual pancreatic islets locates genetic defects in stimulus secretion coupling to Niddm1i within the major diabetes locus in GK ratsQ43808950
Inheritance of diabetes mellitus as consequence of gestational hyperglycemia in ratsQ43811449
Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic ratsQ43901591
Abnormal expression of pancreatic islet exocytotic soluble N-ethylmaleimide-sensitive factor attachment protein receptors in Goto-Kakizaki rats is partially restored by phlorizin treatment and accentuated by high glucose treatmentQ44193765
Enhanced insulin secretion and cholesterol metabolism in congenic strains of the spontaneously diabetic (Type 2) Goto Kakizaki rat are controlled by independent genetic loci in rat chromosome 8.Q44911368
Type 2 diabetes mellitus--genes or intrauterine environment? An embryo transfer paradigm in rats.Q44982604
Diabetes in pregnancy: effects on the foetal and newborn rat with particular regard to body weight, serum insulin concentration and pancreatic contents of insulin, glucagon and somatostatinQ47293878
Disturbed development of the preimplantation embryo in the insulin-dependent diabetic BB/E rat.Q47870454
Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat.Q51584099
Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in KoreaQ57214866
Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK ratQ63432900
The endocrine pancreas of the fetus from diabetic pregnant ratQ67436756
Effect of a low protein diet during pregnancy on the fetal rat endocrine pancreasQ68495936
Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twinsQ68535734
Impaired glucose homeostasis in adult rats from hyperglycemic mothersQ68895015
Diabetes in identical twins. A study of 200 pairsQ70659026
Folate, DNA methylation, and gene expression: factors of nature and nurtureQ73019065
Pathophysiological and genetic characterization of the major diabetes locus in GK ratsQ73224803
Hyperglycemic crises in patients with diabetes mellitusQ73548236
Early development of beta-cells is impaired in the GK rat model of type 2 diabetesQ73680089
Structural and functional abnormalities in the islets isolated from type 2 diabetic subjectsQ76385432
Beta-cell growth in the neonatal Goto-Kakisaki rat and regeneration after treatment with streptozotocin at birthQ78126454
Age-dependent inability of the endocrine pancreas to adapt to pregnancy: a long-term consequence of perinatal malnutrition in the ratQ78180951
P433issue6
P921main subjecttype 2 diabetesQ3025883
P304page(s)495-504
P577publication date2005-11-01
P1433published inDiabetes - Metabolism: Research and ReviewsQ15750056
P1476titleProgrammed disorders of beta-cell development and function as one cause for type 2 diabetes? The GK rat paradigm
P478volume21

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