Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs?

scientific article published in May 2012

Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs? is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/J.1476-5381.2011.01525.X
P932PMC publication ID3415637
P698PubMed publication ID21649645
P5875ResearchGate publication ID51199002

P50authorJulia K ArchboldQ56826702
James BarwellQ117263046
Debbie HayQ37829061
David R PoynerQ37829072
Joseph GingellQ59560340
P2093author name stringHarriet A Watkins
P2860cites workThe mid-region of parathyroid hormone (1-34) serves as a functional docking domain in receptor activation.Q53552116
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The N-Terminal Extracellular Domain 23−60 of the Calcitonin Receptor-Like Receptor in Chimeras with the Parathyroid Hormone Receptor Mediates Association with Receptor Activity-Modifying Protein 1†Q58185840
Characterization of parathyroid hormone/receptor interactions: structure of the first extracellular loopQ73977450
Contribution of the second transmembrane helix of the secretin receptor to the positioning of secretinQ74432807
The role of the fourth extracellular domain of the rat corticotropin-releasing factor receptor type 1 in ligand bindingQ77892735
Class-B GPCR activation: is ligand helix-capping the key?Q81459822
Identification and pharmacological characterization of domains involved in binding of CGRP receptor antagonists to the calcitonin-like receptorQ82476591
Conformation of a peptide ligand bound to its G-protein coupled receptorQ24290821
Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2Q24295086
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptorQ24323946
Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptorQ24644625
Dimeric Arrangement of the Parathyroid Hormone Receptor and a Structural Mechanism for Ligand-induced DissociationQ27659967
Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonismQ27664362
Converting the Highly Amyloidogenic Human Calcitonin into a Powerful Fibril Inhibitor by Three-dimensional Structure Homology with a Non-amyloidogenic AnalogueQ27665898
Crystal Structure of the PAC1R Extracellular Domain Unifies a Consensus Fold for Hormone Recognition by Class B G-Protein Coupled ReceptorsQ27668088
Structure of the integral membrane domain of the GLP1 receptorQ28138164
Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexesQ28184238
International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptorsQ28201576
Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminusQ28201902
Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptorQ28214136
Novel receptor partners and function of receptor activity-modifying proteinsQ28215813
Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor homo-oligomer and a monomer of receptor activity-modifying protein-1Q28245013
Pattern of intra-family hetero-oligomerization involving the G-protein-coupled secretin receptorQ37430299
The second intracellular loop of the calcitonin gene-related peptide receptor provides molecular determinants for signal transduction and cell surface expressionQ38318694
Alanine scanning mutagenesis of the second extracellular loop of type 1 corticotropin-releasing factor receptor revealed residues critical for peptide bindingQ39898479
Diverse Functional Motifs within the Three Intracellular Loops of the CGRP1Receptor†Q60665822
Functionally different isoforms of the human calcitonin receptor result from alternative splicing of the gene transcriptQ71523035
Full activation of chimeric receptors by hybrids between parathyroid hormone and calcitonin. Evidence for a common pattern of ligand-receptor interactionQ71742566
Scanning of the glucagon-like peptide-1 receptor localizes G protein-activating determinants primarily to the N terminus of the third intracellular loopQ73202207
Role of charged amino acids conserved in the vasoactive intestinal polypeptide/secretin family of receptors on the secretin receptor functionalityQ73208211
Mutational Analysis of Extracellular Cysteine Residues of Rat Secretin Receptor Shows that Disulfide Bridges are Essential for Receptor FunctionQ73483154
Residues in the membrane-spanning and extracellular loop regions of the parathyroid hormone (PTH)-2 receptor determine signaling selectivity for PTH and PTH-related peptideQ73853906
Mapping the bimolecular interface of the parathyroid hormone (PTH)-PTH1 receptor complex: spatial proximity between Lys(27) (of the hormone principal binding domain) and leu(261) (of the first extracellular loop) of the human PTH1 receptorQ73977445
GPCR modulation by RAMPsQ28268136
Distinct receptor activity-modifying protein domains differentially modulate interaction with calcitonin receptorsQ28301498
Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptorsQ28303314
Divergent structural requirements exist for calcitonin receptor binding specificity and adenylate cyclase activationQ28569619
The third cytoplasmic domain of the GLP-1[7-36 amide] receptor is required for coupling to the adenylyl cyclase systemQ28574405
Structure of the integral membrane domain of the GLP1 receptorQ29540751
The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprintsQ29547321
Twilight zone of protein sequence alignmentsQ29614388
Passing the baton in class B GPCRs: peptide hormone activation via helix induction?Q30319107
A study of the membrane-water interface region of membrane proteins.Q30350022
Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activationQ30522852
High-throughput modeling of human G-protein coupled receptors: amino acid sequence alignment, three-dimensional model building, and receptor library screeningQ31063961
Identification of specific calcitonin-like receptor residues important for calcitonin gene-related peptide high affinity bindingQ33246847
Mapping peptide hormone-receptor interactions using a disulfide-trapping approachQ33331953
Secretin occupies a single protomer of the homodimeric secretin receptor complex: insights from photoaffinity labeling studies using dual sites of covalent attachmentQ33744723
A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.Q33779634
CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors.Q33910430
Protein-protein interaction and not glycosylation determines the binding selectivity of heterodimers between the calcitonin receptor-like receptor and the receptor activity-modifying proteinsQ33949422
The delta e13 isoform of the calcitonin receptor forms a six-transmembrane domain receptor with dominant-negative effects on receptor surface expression and signaling.Q34063180
Importance of lipid-exposed residues in transmembrane segment four for family B calcitonin receptor homo-dimerizationQ34079450
Elucidation of the active conformation of the amino terminus of receptor-bound secretin using intramolecular disulfide bond constraintsQ34143310
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A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors.Q34379110
Ligand binding and activation of the CGRP receptor.Q34654527
Refinement of glucagon-like peptide 1 docking to its intact receptor using mid-region photolabile probes and molecular modelingQ34963202
Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptorsQ36088758
The membrane-water interface region of membrane proteins: structural bias and the anti-snorkeling effectQ36151469
Conformational changes in the parathyroid hormone receptor associated with activation by agonistQ36629313
The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state.Q36693902
Structural characterization of the parathyroid hormone receptor domains determinant for ligand bindingQ36883912
Molecular mechanisms involved in vasoactive intestinal peptide receptor activation and regulation: current knowledge, similarities to and differences from the A family of G-protein-coupled receptorsQ36883918
Computational studies of Family A and Family B GPCRsQ36883937
PTH and PTH antagonist induce different conformational changes in the PTHR1 receptorQ37166813
Modulating receptor function through RAMPs: can they represent drug targets in themselves?Q37371266
Juxtamembranous region of the amino terminus of the family B G protein-coupled calcitonin receptor plays a critical role in small-molecule agonist actionQ37372130
Photoaffinity cross-linking of the corticotropin-releasing factor receptor type 1 with photoreactive urocortin analogues.Q40349088
Molecular and functional characterization of adrenomedullin receptors in pufferfishQ40367201
Contribution of the carboxyl terminus of the VPAC1 receptor to agonist-induced receptor phosphorylation, internalization, and recyclingQ40414038
Molecular approximation between a residue in the amino-terminal region of calcitonin and the third extracellular loop of the class B G protein-coupled calcitonin receptorQ40553493
Met-204 and Tyr-205 are together important for binding GLP-1 receptor agonists but not their N-terminally truncated analoguesQ40589773
Importance of the amino terminus in secretin family G protein-coupled receptors. Intrinsic photoaffinity labeling establishes initial docking constraints for the calcitonin receptorQ40621953
The glucagon-like peptide-1 receptor binding site for the N-terminus of GLP-1 requires polarity at Asp198 rather than negative chargeQ40696352
Functional roles of conserved transmembrane prolines in the human VPAC(1) receptorQ40785081
Mutations of the asparagine117 residue of a receptor activity-modifying protein 1-dependent human calcitonin gene-related peptide receptor result in selective loss of functionQ40809163
Determinants for calcitonin analog interaction with the calcitonin receptor N-terminus and transmembrane-loop regionsQ41155912
Multiple extracellular loop domains contribute critical determinants for agonist binding and activation of the secretin receptorQ41190802
Mutations of neighboring polar residues on the second transmembrane helix disrupt signaling by the parathyroid hormone receptorQ41231338
Truncation of the porcine calcitonin receptor cytoplasmic tail inhibits internalization and signal transduction but increases receptor affinityQ41423560
Agonist-dependent consequences of proline to alanine substitution in the transmembrane helices of the calcitonin receptorQ41587491
Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activationQ41670110
Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2.Q41791755
Functional importance of a structurally distinct homodimeric complex of the family B G protein-coupled secretin receptorQ41883095
Residue 17 of sauvagine cross-links to the first transmembrane domain of corticotropin-releasing factor receptor 1 (CRFR1).Q41954586
The minor binding pocket: a major player in 7TM receptor activationQ42876628
Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23-60 of the calcitonin receptor-like receptorQ42933738
Evidence that interaction between conserved residues in transmembrane helices 2, 3, and 7 are crucial for human VPAC1 receptor activationQ43007364
Mapping the CGRP receptor ligand binding domain: tryptophan-84 of RAMP1 is critical for agonist and antagonist bindingQ43148072
Two basic residues of the h-VPAC1 receptor second transmembrane helix are essential for ligand binding and signal transductionQ43507743
Structure–function analysis of helix 8 of human calcitonin receptor-like receptor within the adrenomedullin 1 receptorQ43532009
Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR.Q43616414
Differential conformational requirements for activation of G proteins and the regulatory proteins arrestin and G protein-coupled receptor kinase in the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related proteinQ43626694
Sauvagine cross-links to the second extracellular loop of the corticotropin-releasing factor type 1 receptorQ44005255
The alternatively spliced deltae13 transcript of the rabbit calcitonin receptor dimerizes with the C1a isoform and inhibits its surface expressionQ44397881
Identification of cytoplasmic domains of hVPAC1 receptor required for activation of adenylyl cyclase. Crucial role of two charged amino acids strictly conserved in class II G protein-coupled receptors.Q44400097
Identification of a contact site for residue 19 of parathyroid hormone (PTH) and PTH-related protein analogs in transmembrane domain two of the type 1 PTH receptorQ44567784
The positive charge at Lys-288 of the glucagon-like peptide-1 (GLP-1) receptor is important for binding the N-terminus of peptide agonists.Q44627982
Aspartate(69) of the calcitonin-like receptor is required for its functional expression together with receptor-activity-modifying proteins 1 and -2.Q44934476
Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptorsQ45711499
Dihydropyrrole[2,3-d]pyridine derivatives as novel corticotropin-releasing factor-1 antagonists: mapping of the receptor binding pocket by in silico docking studiesQ46271258
Effect of inactivating mutations on phosphorylation and internalization of the human VPAC2 receptorQ46430496
Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labelingQ46522310
Localization of agonist- and antagonist-binding domains of human corticotropin-releasing factor receptorsQ46679915
Methionine acts as a "magnet" in photoaffinity crosslinking experimentsQ46974696
Fluorescence resonance energy transfer analysis of secretin docking to its receptor: mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues.Q51794822
The extreme N-terminus of the calcitonin-like receptor contributes to the selective interaction with adrenomedullin or calcitonin gene-related peptide.Q51841685
The arrangement of the transmembrane helices in the secretin receptor family of G-protein-coupled receptors.Q52867927
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectG protein-coupled receptorQ38173
calcitonin receptor activityQ14905622
P304page(s)51-65
P577publication date2012-05-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleCalcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs?
P478volume166