A Nuclear localization signal in herpesvirus protein VP1-2 is essential for infection via capsid routing to the nuclear pore.

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A Nuclear localization signal in herpesvirus protein VP1-2 is essential for infection via capsid routing to the nuclear pore. is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.01209-12
P932PMC publication ID3416164
P698PubMed publication ID22718835

P50authorColin M CrumpQ52644705
Peter O'HareQ61306670
P2093author name stringF Abaitua
M Bolstad
P O'Hare
M Hollinshead
P2860cites workTransport between the cell nucleus and the cytoplasmQ22065411
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Proteolytic cleavage of VP1-2 is required for release of herpes simplex virus 1 DNA into the nucleusQ24652886
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Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymesQ27644017
Nuclear entry of hepatitis B virus capsids involves disintegration to protein dimers followed by nuclear reassociation to capsidsQ28475989
Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration.Q30406846
The C terminus of the large tegument protein pUL36 contains multiple capsid binding sites that function differently during assembly and cell entry of herpes simplex virusQ30424771
Structure and capsid association of the herpesvirus large tegument protein UL36.Q30433083
Herpes simplex virus replication: roles of viral proteins and nucleoporins in capsid-nucleus attachmentQ30439071
The pseudorabies virus VP1/2 tegument protein is required for intracellular capsid transportQ30476546
Identification of an essential domain in the herpesvirus VP1/2 tegument protein: the carboxy terminus directs incorporation into capsid assemblonsQ30478390
Identification of functional domains within the essential large tegument protein pUL36 of pseudorabies virusQ40069602
The capsid and tegument of the alphaherpesviruses are linked by an interaction between the UL25 and VP1/2 proteins.Q40090326
Essential function of the pseudorabies virus UL36 gene product is independent of its interaction with the UL37 proteinQ40214353
The inner tegument promotes herpes simplex virus capsid motility along microtubules in vitroQ40328028
Entry of pseudorabies virus: an immunogold-labeling study.Q40458889
Herpesvirus capsid association with the nuclear pore complex and viral DNA release involve the nucleoporin CAN/Nup214 and the capsid protein pUL25.Q41361749
Differing roles of inner tegument proteins pUL36 and pUL37 during entry of herpes simplex virus type 1.Q42151114
Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1.Q43848059
Two-step red-mediated recombination for versatile high-efficiency markerless DNA manipulation in Escherichia coliQ45856655
Axoplasmic importins enable retrograde injury signaling in lesioned nerve.Q47306740
Construction and characterization of bacterial artificial chromosomes containing HSV-1 strains 17 and KOS.Q54466112
Residues F593 and E596 of HSV-1 tegument protein pUL36 (VP1/2) mediate binding of tegument protein pUL37Q57076523
Molecular components of the centrosomeQ75293454
Targeting of herpesvirus capsid transport in axons is coupled to association with specific sets of tegument proteinsQ30856858
A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family HerpesviridaeQ31000683
A herpesvirus encoded deubiquitinase is a novel neuroinvasive determinantQ33432679
The major determinant for addition of tegument protein pUL48 (VP16) to capsids in herpes simplex virus type 1 is the presence of the major tegument protein pUL36 (VP1/2)Q33614481
Plus- and minus-end directed microtubule motors bind simultaneously to herpes simplex virus capsids using different inner tegument structuresQ33632158
A null mutation in the UL36 gene of herpes simplex virus type 1 results in accumulation of unenveloped DNA-filled capsids in the cytoplasm of infected cellsQ33812522
Herpes simplex virus type 1 entry into host cells: reconstitution of capsid binding and uncoating at the nuclear pore complex in vitroQ33964524
Viral entry into the nucleusQ34059747
Identification of host cell proteins which interact with herpes simplex virus type 1 tegument protein pUL37.Q34112692
Composition of pseudorabies virus particles lacking tegument protein US3, UL47, or UL49 or envelope glycoprotein E.Q34302219
Herpesvirus assembly and egressQ34499618
A single mutation responsible for temperature-sensitive entry and assembly defects in the VP1-2 protein of herpes simplex virus.Q34741989
Break ins and break outs: viral interactions with the cytoskeleton of Mammalian cells.Q34762508
Nuclear import of viral DNA genomes.Q35092065
Autocatalytic activity of the ubiquitin-specific protease domain of herpes simplex virus 1 VP1-2.Q35192778
HIV-1 remodels the nuclear pore complexQ35196075
Molecular genetics of herpes simplex virus. VI. Characterization of a temperature-sensitive mutant defective in the expression of all early viral gene productsQ35237702
Importin α: a multipurpose nuclear-transport receptorQ35879618
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A herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formation.Q36289021
Proteins specified by herpes simplex virus. XII. The virion polypeptides of type 1 strainsQ36564133
Identification of a highly conserved, functional nuclear localization signal within the N-terminal region of herpes simplex virus type 1 VP1-2 tegument proteinQ36673366
Characterization of the herpes simplex virion-associated factor responsible for the induction of alpha genes.Q36905768
Molecular genetics of herpes simplex virus. VIII. further characterization of a temperature-sensitive mutant defective in release of viral DNA and in other stages of the viral reproductive cycleQ36929479
Nuclear transport factors in neuronal functionQ37466963
Strategies to inhibit viral protein nuclear import: HIV-1 as a targetQ37780819
How viruses access the nucleus.Q37822075
Microtubule nucleation by γ-tubulin complexesQ37945020
Identification of a 709-amino-acid internal nonessential region within the essential conserved tegument protein (p)UL36 of pseudorabies virusQ38761116
Pseudorabies virus UL36 tegument protein physically interacts with the UL37 proteinQ39682897
Random transposon-mediated mutagenesis of the essential large tegument protein pUL36 of pseudorabies virusQ39695155
The UL25 gene product of herpes simplex virus type 1 is involved in uncoating of the viral genomeQ39766055
Intracellular localization of the pseudorabies virus large tegument protein pUL36.Q39819252
Characterization of the herpes simplex virus (HSV)-1 tegument protein VP1-2 during infection with the HSV temperature-sensitive mutant tsB7.Q39827341
UL36p is required for efficient transport of membrane-associated herpes simplex virus type 1 along microtubulesQ39979847
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)8998-9014
P577publication date2012-06-20
P1433published inJournal of VirologyQ1251128
P1476titleA Nuclear localization signal in herpesvirus protein VP1-2 is essential for infection via capsid routing to the nuclear pore
P478volume86