TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals

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TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1113/JPHYSIOL.2005.088963
P8608Fatcat IDrelease_6kjlz4x3yjee7c3s76qsos7sw4
P932PMC publication ID1474158
P698PubMed publication ID15961428
P5875ResearchGate publication ID7782742

P2093author name stringWolfgang Liedtke
P2860cites workOTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarityQ24290380
Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stressQ24292923
Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptorQ24647926
Positioning of cell growth and division after osmotic stress requires a MAP kinase pathway.Q27930462
An osmosensing signal transduction pathway in yeast.Q27932086
Impaired osmotic sensation in mice lacking TRPV4Q28588195
Hypothalamic integration of body fluid regulationQ28776115
Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegansQ30498209
Abnormal osmotic regulation in trpv4 -/- miceQ30501210
Gramicidin A channels switch between stretch activation and stretch inactivation depending on bilayer thicknessQ34047621
Caenorhabditis elegans TRPV ion channel regulates 5HT biosynthesis in chemosensory neuronsQ34302924
Sensory mechanisms in the behavioral control of body fluid balance: thirst and salt appetiteQ34358120
OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegansQ34442691
Neural pathways from the lamina terminalis influencing cardiovascular and body fluid homeostasisQ34570403
Osmotic adaptation in yeast--control of the yeast osmolyte systemQ34600062
The TRPV4 channel: structure-function relationship and promiscuous gating behaviour.Q35114819
Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4.Q35123129
Vertebrate and invertebrate TRPV-like mechanoreceptorsQ35135496
Efferent neural pathways of the lamina terminalis subserving osmoregulationQ35420143
Ion channels and transporters involved in cell volume regulation and sensor mechanismsQ35913856
Cellular volume homeostasisQ35951180
A dual mechanosensory and chemosensory neuron in Caenorhabditis elegansQ36161991
The lamina terminalis and its neural connections: neural circuitry involved in angiotensin action and fluid and electrolyte homeostasisQ38719484
Response of human cells to desiccation: comparison with hyperosmotic stress responseQ40555549
Differential activation of the volume-sensitive cation channel TRP12 (OTRPC4) and volume-regulated anion currents in HEK-293 cellsQ40767910
Trp12, a novel Trp related protein from kidneyQ40840056
Osmoreceptors in the central nervous systemQ41388091
Signal transduction in the Caenorhabditis elegans nervous systemQ41733294
A perfused in vitro preparation of hypothalamus for electrophysiological studies on neurosecretory neuronsQ42446737
Molecular determinants of permeation through the cation channel TRPV4.Q44047575
Impaired Pressure Sensation in Mice Lacking TRPV4Q44401201
Specific polyunsaturated fatty acids drive TRPV-dependent sensory signaling in vivoQ45193556
Polymodal sensory function of the Caenorhabditis elegans OCR-2 channel arises from distinct intrinsic determinants within the protein and is selectively conserved in mammalian TRPV proteins.Q45240224
Osmotic regulation in adult Drosophila melanogaster during dehydration and rehydration.Q45958955
The lamina terminalis and its role in fluid and electrolyte homeostasisQ73843000
P433issuePt 1
P407language of work or nameEnglishQ1860
P304page(s)53-58
P577publication date2005-06-16
P1433published inJournal of PhysiologyQ7743612
P1476titleTRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals
P478volume567

Reverse relations

cites work (P2860)
Q40062691A role of the transient receptor potential domain of vanilloid receptor I in channel gating.
Q33987179Activation of Trpv4 reduces the hyperproliferative phenotype of cystic cholangiocytes from an animal model of ARPKD.
Q38888160Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy
Q37100471Altered central TRPV4 expression and lipid raft association related to inappropriate vasopressin secretion in cirrhotic rats.
Q61448131Cannabinoid Ligands Targeting TRP Channels
Q37199237Changes in osmolality modulate voltage-gated sodium channels in trigeminal ganglion neurons
Q36277264Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion.
Q34522629Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice.
Q33810382Contribution of primary afferent channels to neuropathic pain
Q33608790Correlation between urothelial differentiation and sensory proteins P2X3, P2X5, TRPV1, and TRPV4 in normal urothelium and papillary carcinoma of human bladder
Q36832733Current understanding on the neurophysiology of behavioral thermoregulation
Q36607312Damage to lens fiber cells causes TRPV4-dependent Src family kinase activation in the epithelium
Q58628524Effect of osmotic stress on the expression of TRPV4 and BKCa channels and possible interaction with ERK1/2 and p38 in cultured equine chondrocytes
Q36632061Fluid transport phenomena in ocular epithelia
Q40422746Human Digital Meissner Corpuscles Display Immunoreactivity for the Multifunctional Ion Channels Trpc6 and Trpv4.
Q33664676Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain
Q38179569In search of the pivot point of mechanotransduction: mechanosensing of stem cells
Q39306483Inhibition of the expression and function of TRPV4 by RNA interference in dorsal root ganglion
Q46240105Mechanosensitive ion channels in dystrophic muscle.
Q34264627Mechanosensory neurons, cutaneous mechanoreceptors, and putative mechanoproteins
Q42515042Merkel cells and Meissner's corpuscles in human digital skin display Piezo2 immunoreactivity.
Q34163391Molecular mechanisms of mechanotransduction in mammalian sensory neurons
Q35079012Osmolarity influences chondrocyte repair after injury in human articular cartilage
Q34247319Portal osmopressor mechanism linked to transient receptor potential vanilloid 4 and blood pressure control
Q36884815Regulation of Piezo2 Mechanotransduction by Static Plasma Membrane Tension in Primary Afferent Neurons
Q36908219Salt-sensing mechanisms in blood pressure regulation and hypertension
Q96304420Soft Tissue: A Possible Source of Pain Pre and Post Minimally Invasive Spine Surgery
Q30501459TRP channels as candidates for hearing and balance abnormalities in vertebrates.
Q30587013TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour
Q36487773TRPV1 (vanilloid receptor) in the urinary tract: expression, function and clinical applications.
Q36547404TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure.
Q30438420TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling
Q99712208TRPV4-Mediated Regulation of the Blood Brain Barrier Is Abolished During Inflammation
Q36845497TRPs in bladder diseases
Q42371395The pain threshold of high-threshold mechanosensitive receptors subsequent to maximal eccentric exercise is a potential marker in the prediction of DOMS associated impairment
Q99730948The role of TRPV4 channels in ocular function and pathologies
Q64097597Transcription factor Sp4 is required for hyperalgesic state persistence
Q36926550Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury.
Q35850305Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension
Q30440958Urothelial signaling
Q84375630Urothelial signaling
Q47228512When size matters: transient receptor potential vanilloid 4 channel as a volume-sensor rather than an osmo-sensor.

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