Sphingosine-1-phosphate: an emerging therapeutic target

scientific article

Sphingosine-1-phosphate: an emerging therapeutic target is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1517/14728222.5.1.109
P698PubMed publication ID15992170

P2093author name stringSpiegel S
Milstien S
Toman RE
P2860cites workVascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphateQ22010773
Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5Q22011004
Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoformQ22253469
Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1Q24314828
Cloning and characterization of a putative G-protein coupled receptor potentially involved in developmentQ24320006
Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturationQ24629370
Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell deathQ24679258
The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyaseQ27930762
Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neuronsQ48259380
Embryonic expression pattern of H218, a G-protein coupled receptor homolog, suggests roles in early mammalian nervous system development.Q48680026
Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destructionQ48950370
Antisense studies in PC12 cells suggest a role for H218, a sphingosine 1-phosphate receptor, in growth-factor-induced cell-cell interaction and neurite outgrowth.Q52165671
The DPL1 gene is involved in mediating the response to nutrient deprivation in Saccharomyces cerevisiaeQ27931101
Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphataseQ27936263
Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapyQ28140319
Functional characterization of human sphingosine kinase-1Q28143917
Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeastQ28261678
Molecular cloning and functional characterization of murine sphingosine kinaseQ28281335
Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218Q28297208
Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cellsQ28375565
Mammalian lipid phosphate phosphohydrolasesQ28594743
Tumor necrosis factor-  induces adhesion molecule expression through the sphingosine kinase pathwayQ29041393
Angiogenesis in cancer, vascular, rheumatoid and other diseaseQ29547165
Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signalingQ30176570
Molecular cloning, tissue-specific expression, and chromosomal localization of a novel nerve growth factor-regulated G-protein- coupled receptor, nrg-1.Q30799682
Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1.Q31626065
Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptorsQ32064388
Cloning of cDNAs encoding G protein-coupled receptor expressed in human endothelial cells exposed to fluid shear stressQ32179252
Ceramide induces apoptosis to immature cerebellar granule cells in cultureQ33178433
A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs).Q33651530
Sphingosine-1-phosphate: extracellular mediator or intracellular second messenger?Q33697778
Induction of endothelial cell chemotaxis by sphingosine 1-phosphate and stabilization of endothelial monolayer barrier function by lysophosphatidic acid, potential mediators of hematopoietic angiogenesisQ33887527
Sphingosine-1-phosphate: signaling inside and out.Q33957118
The role of sphingosine kinase in the signaling initiated at the high-affinity receptor for IgE (FcepsilonRI) in mast cellsQ33957281
Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response.Q35670314
Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transductionQ36235805
Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survivalQ36256204
Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.Q36294755
Identification of a Saccharomyces gene, LCB3, necessary for incorporation of exogenous long chain bases into sphingolipidsQ36867200
Functions of sphingolipids and sphingolipid breakdown products in cellular regulationQ38597926
Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis.Q40845943
Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesisQ40914150
FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular traffickingQ41041395
Alteration of the sphingomyelin/ceramide pathway is associated with resistance of human breast carcinoma MCF7 cells to tumor necrosis factor-alpha-mediated cytotoxicityQ41121005
Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptorQ41205257
Functions of ceramide in coordinating cellular responses to stressQ41243489
Blood vessel formation: what is its molecular basis?Q41288467
Apoptosis, excitotoxicity, and neuropathologyQ41729276
Regulation of ceramide production and apoptosisQ41748407
A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart developmentQ41750054
The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc epsilon receptor I triggeringQ42136631
Bimodal regulation of ceramidase by interleukin-1beta. Implications for the regulation of cytochrome p450 2C11.Q42441554
N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide.Q42461110
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphateQ42556020
Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogensQ42805681
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectsphingosine 1-phosphateQ418267
P304page(s)109-123
P577publication date2001-02-01
P1433published inExpert Opinion on Therapeutic TargetsQ5421214
P1476titleSphingosine-1-phosphate: an emerging therapeutic target
P478volume5

Reverse relations

cites work (P2860)
Q33829692Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget
Q35598506SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae.
Q30482054The repertoire of G protein-coupled receptors in the sea squirt Ciona intestinalis.

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