PML represses lung cancer metastasis by suppressing the nuclear EGFR-mediated transcriptional activation of MMP2.

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PML represses lung cancer metastasis by suppressing the nuclear EGFR-mediated transcriptional activation of MMP2. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4161/15384101.2014.949212
P932PMC publication ID4614437
P698PubMed publication ID25486572
P5875ResearchGate publication ID269338895

P50authorYen-Sung HuangQ55266809
P2093author name stringHsiu-Ming Shih
Yi-Chen Chen
Cheng-Wen Wu
Yu-Wei Chang
Hong-Yi Kuo
Chin-Hsiu Tseng
P2860cites workGlobal cancer statisticsQ22241238
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A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progressionQ24322269
EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatmentQ24338426
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Mesenchymal Stem Cells Overexpressing IFN-β Inhibit Breast Cancer Growth and Metastases through Stat3 Signaling in a Syngeneic Tumor ModelQ34343680
The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleusQ34352437
Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cellsQ35063410
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Nuclear EGFR suppresses ribonuclease activity of polynucleotide phosphorylase through DNAPK-mediated phosphorylation at serine 776.Q36225686
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Integrative analyses identify osteopontin, LAMB3 and ITGB1 as critical pro-metastatic genes for lung cancer.Q36618490
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Co-regulation of B-Myb expression by E2F1 and EGF receptorQ38318606
The PML isoform IV is a negative regulator of nuclear EGFR's transcriptional activity in lung cancerQ39170227
Multidrug-resistant cells overexpressing P-glycoprotein are susceptible to DNA crosslinking agents due to attenuated Src/nuclear EGFR cascade-activated DNA repair activityQ39360651
Nuclear EGFR shuttling induced by ionizing radiation is regulated by phosphorylation at residue Thr654Q39670051
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Interferon-beta induces S phase slowing via up-regulated expression of PML in squamous carcinoma cellsQ40847270
Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell lineQ41089777
Nuclear EGFR is required for cisplatin resistance and DNA repairQ41953402
PML: An emerging tumor suppressor and a target with therapeutic potential.Q41971647
miR‑133a suppresses cell proliferation, migration and invasion in human lung cancer by targeting MMP‑14.Q45993947
Stat3 is involved in angiotensin II-induced expression of MMP2 in gastric cancer cellsQ46198272
Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasisQ47677996
Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element.Q48068389
Transcriptional suppression of matrix metalloproteinase-2 gene expression in human astroglioma cells by TNF-alpha and IFN-gammaQ48323889
Epidermal Growth Factor Receptors Control Competence to Interpret Leukemia Inhibitory Factor as an Astrocyte Inducer in Developing CortexQ48324514
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EGFR promotes lung tumorigenesis by activating miR-7 through a Ras/ERK/Myc pathway that targets the Ets2 transcriptional repressor ERF.Q54638194
Nuclear EGFR in ductal invasive breast cancer: correlation with cyclin-D1 and prognosis.Q54699349
Modulation of monocytes matrix metalloproteinase-2, MT1-MMP and TIMP-2 by interferon-gamma and -beta: implications to multiple sclerosisQ78590833
Relationship between matrix metalloproteinase 2 and lung cancer progressionQ80481862
Increased expression of matrix metalloproteinase-2 (MMP-2) predicts tumour recurrence and unfavourable outcome in non-small cell lung cancerQ80954371
Expression of KISS1 and MMP-9 in non-small cell lung cancer and their relations to metastasis and survivalQ84066257
P4510describes a project that usesImageJQ1659584
P433issue19
P921main subjectcancer metastasisQ120912394
P1104number of pages11
P304page(s)3132-3142
P577publication date2014-01-01
P1433published inCell CycleQ1254166
P1476titlePML represses lung cancer metastasis by suppressing the nuclear EGFR-mediated transcriptional activation of MMP2
P478volume13