Pharmacokinetics of sepantronium bromide (YM155), a small-molecule suppressor of survivin, in Japanese patients with advanced solid tumors: dose proportionality and influence of renal impairment

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Pharmacokinetics of sepantronium bromide (YM155), a small-molecule suppressor of survivin, in Japanese patients with advanced solid tumors: dose proportionality and influence of renal impairment is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00280-012-1913-Z
P932PMC publication ID3428524
P698PubMed publication ID22806304
P5875ResearchGate publication ID229160424

P2093author name stringKazuhiko Nakagawa
Taroh Satoh
Masataka Katashima
Taiji Sawamoto
Tetsuya Nishimura
Yumiko Aoyama
P2860cites workA multi-center phase II evaluation of the small molecule survivin suppressor YM155 in patients with unresectable stage III or IV melanomaQ63874514
Involvement of human organic cation transporter 1 in the hepatic uptake of 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide (YM155 monobromide), a novel, small molecule survivin suppressanQ84059609
Multicenter phase II trial of YM155, a small-molecule suppressor of survivin, in patients with advanced, refractory, non-small-cell lung cancerQ84420058
When to conduct a renal impairment study during drug development: US Food and Drug Administration perspectiveQ84755383
Evidence-based practice guideline for the treatment of CKDQ84978295
K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratificationQ29547560
Phase I and pharmacokinetic study of YM155, a small-molecule inhibitor of survivin.Q36934286
Emerging evidence of the impact of kidney disease on drug metabolism and transportQ37128651
YM155, a novel survivin suppressant, enhances taxane-induced apoptosis and tumor regression in a human Calu 6 lung cancer xenograft modelQ39578508
Antitumor effects of YM155, a novel survivin suppressant, against human aggressive non-Hodgkin lymphomaQ39607547
Broad spectrum and potent antitumor activities of YM155, a novel small-molecule survivin suppressant, in a wide variety of human cancer cell lines and xenograft modelsQ39612451
Phase I study of YM155, a novel survivin suppressant, in patients with advanced solid tumorsQ40388768
YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts.Q51794884
TablesQ56385764
P433issue3
P921main subjectpharmacokineticsQ323936
sepantronium bromideQ27268284
P304page(s)373-380
P577publication date2012-07-18
P1433published inCancer Chemotherapy and PharmacologyQ326137
P1476titlePharmacokinetics of sepantronium bromide (YM155), a small-molecule suppressor of survivin, in Japanese patients with advanced solid tumors: dose proportionality and influence of renal impairment
P478volume70

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cites work (P2860)
Q38115574Manipulating the apoptotic pathway: potential therapeutics for cancer patients
Q35049080Response of Merkel cell polyomavirus-positive merkel cell carcinoma xenografts to a survivin inhibitor
Q38750224Small Molecule Survivin Inhibitor YM155 Displays Potent Activity Against Human Osteosarcoma Cells
Q45191171The Effect of Uremic Solutes on the Organic Cation Transporter 2.
Q46889307YM155 sensitizes triple-negative breast cancer to membrane-bound TRAIL through p38 MAPK- and CHOP-mediated DR5 upregulation.

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