Irisin Ameliorates Hypoxia/Reoxygenation-Induced Injury through Modulation of Histone Deacetylase 4

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Irisin Ameliorates Hypoxia/Reoxygenation-Induced Injury through Modulation of Histone Deacetylase 4 is …
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scholarly articleQ13442814

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P819ADS bibcode2016PLoSO..1166182Z
P356DOI10.1371/JOURNAL.PONE.0166182
P932PMC publication ID5119735
P698PubMed publication ID27875543

P50authorHao WangQ89239695
Shouyan ZhangQ91670493
P2093author name stringShougang Zhuang
Jianfeng Du
Ting C Zhao
Yu Tina Zhao
P2860cites workReactive oxygen species-independent apoptosis in doxorubicin-treated H9c2 cardiomyocytes: role for heme oxygenase-1 down-modulationQ46323571
Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic bandingQ46870302
Inhibition of histone deacetylases triggers pharmacologic preconditioning effects against myocardial ischemic injuryQ46990138
Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice.Q53293416
Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nitrative stresses.Q53401245
Fenofibrate (PPARalpha agonist) induces beige cell formation in subcutaneous white adipose tissue from diet-induced male obese mice.Q53647740
The whole body cryostimulation modifies irisin concentration and reduces inflammation in middle aged, obese menQ57094190
Structure and function of the core histone N-termini: more than meets the eyeQ77917240
Postconditioning inhibits mitochondrial permeability transitionQ81252248
Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.Q27863703
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesisQ28588558
GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.Q29871472
Mitochondria and cell death. Mechanistic aspects and methodological issuesQ33734610
The clinical development of histone deacetylase inhibitors as targeted anticancer drugsQ33829390
gp-91 mediates histone deacetylase inhibition-induced cardioprotectionQ33892798
Targeted deletion of NF-kappaB p50 diminishes the cardioprotection of histone deacetylase inhibitionQ33917016
Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophyQ33929939
HDAC4: mechanism of regulation and biological functionsQ34039987
Specific inhibition of HDAC4 in cardiac progenitor cells enhances myocardial repairsQ34062891
Mitochondria: a target for myocardial protection.Q34228064
Stimulation of glucagon-like peptide-1 receptor through exendin-4 preserves myocardial performance and prevents cardiac remodeling in infarcted myocardiumQ34355984
Role of the mitochondrial permeability transition in myocardial diseaseQ35204734
HDAC4 degradation mediates HDAC inhibition-induced protective effects against hypoxia/reoxygenation injuryQ35216855
Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotectionQ35666876
Inhibition of histone deacetylases preserves myocardial performance and prevents cardiac remodeling through stimulation of endogenous angiomyogenesisQ35847709
Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic miceQ35922922
HDAC inhibition promotes cardiogenesis and the survival of embryonic stem cells through proteasome-dependent pathwayQ35975931
Inhibition of histone deacetylase-induced myocardial repair is mediated by c-kit in infarcted heartsQ36408024
Hypoxia inhibits cardiomyocyte proliferation in fetal rat hearts via upregulating TIMP-4Q36770762
Banting Lecture 2012: Regulation of adipogenesis: toward new therapeutics for metabolic diseaseQ36867507
Browning of White Fat: Novel Insight Into Factors, Mechanisms, and TherapeuticsQ38859800
New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitroQ38881759
Irisin in patients with nonalcoholic fatty liver diseaseQ39329858
Bufalin induces growth inhibition, cell cycle arrest and apoptosis in human endometrial and ovarian cancer cellsQ39990237
Morphological alterations induced by doxorubicin on H9c2 myoblasts: nuclear, mitochondrial, and cytoskeletal targetsQ39995376
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)e0166182
P577publication date2016-11-22
P1433published inPLOS OneQ564954
P1476titleIrisin Ameliorates Hypoxia/Reoxygenation-Induced Injury through Modulation of Histone Deacetylase 4
P478volume11

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cites work (P2860)
Q88962076Circulating irisin and chemerin levels as predictors of seizure control in children with idiopathic epilepsy
Q92816594Epigenetics: A Potential Mechanism Involved in the Pathogenesis of Various Adverse Consequences of Obstructive Sleep Apnea
Q100391104Irisin attenuates myocardial ischemia/reperfusion-induced cardiac dysfunction by regulating ER-mitochondria interaction through a mitochondrial ubiquitin ligase-dependent mechanism
Q90389687Irisin counteracts high glucose and fatty acid induced cytotoxicity by preserving AMPK-insulin receptor signaling axis in C2C12 myoblast
Q91670499Qishen Yiqi Drop Pill, a novel compound Chinese traditional medicine protects against high glucose-induced injury in cardiomyocytes
Q64106795RFX1 downregulation contributes to TLR4 overexpression in CD14 monocytes via epigenetic mechanisms in coronary artery disease
Q60949452Relationship of Circulating Irisin with Body Composition, Physical Activity, and Cardiovascular and Metabolic Disorders in the Pediatric Population
Q57027840Transgenic overexpression of active HDAC4 in the heart attenuates cardiac function and exacerbates remodeling in infarcted myocardium