Val-Gly-Val-Ala-Pro-Gly, a repeating peptide in elastin, is chemotactic for fibroblasts and monocytes

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Val-Gly-Val-Ala-Pro-Gly, a repeating peptide in elastin, is chemotactic for fibroblasts and monocytes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.99.3.870
P932PMC publication ID2113419
P698PubMed publication ID6547961
P5875ResearchGate publication ID277535262

P2093author name stringR P Mecham
G L Griffin
R M Senior
D W Urry
D S Wrenn
K U Prasad
P2860cites workChemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptidesQ24561769
Chemotactic activity of platelet alpha granule proteins for fibroblastsQ24681385
Elastin synthesis by ligamentum nuchae fibroblasts: effects of culture conditions and extracellular matrix on elastin productionQ36205078
Platelet-derived growth factor in chemotactic for fibroblastsQ36205866
Induction of fibroblast chemotaxis by fibronectin. Localization of the chemotactic region to a 140,000-molecular weight non-gelatin-binding fragmentQ36344526
Monocyte chemotactic peptide receptor. Functional characteristics and ligand-induced regulationQ37002825
Synthetic peptide with cell attachment activity of fibronectinQ37604872
What is elastin; what is not.Q40236465
Elastin structure, biosynthesis, and relation to disease statesQ40297539
Chemotactic responses of fibroblasts to tropoelastin and elastin-derived peptidesQ40681442
Chemotactic activity of elastin-derived peptidesQ40687977
Isolation and amino acid sequences of tropoelastin peptidesQ48004479
Localization of the chemotactic domain in fibronectinQ58908047
Purification and comparison of elastins from different animal speciesQ67526121
Primary structure of porcine tropoelastinQ67582147
Elastin production by cultured calf pulmonary artery endothelial cellsQ70275644
Characterization of soluble peptides of elastin by physical techniquesQ70353154
Elastin Fragments Attract Macrophage Precursors to Diseased Sites in Pulmonary EmphysemaQ70777130
Human platelet-derived growth factor. Purification and resolution into two active protein fractionsQ70875540
The cell binding fragment of fibronectin is chemotactic for fibroblastsQ70938057
Leukocyte chemotaxisQ70980586
Role of attachment factors and attractants in fibroblast chemotaxisQ71366597
Antibodies to insoluble and solubilized elastinQ71947446
The glomerular permeability determined by dextran clearance using Sephadex gel filtrationQ72021219
Antigenicity of elastin: characterization of major antigenic determinants on purified insoluble elastinQ72664627
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectchemotaxisQ658145
P304page(s)870-874
P577publication date1984-09-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleVal-Gly-Val-Ala-Pro-Gly, a repeating peptide in elastin, is chemotactic for fibroblasts and monocytes
P478volume99

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cites work (P2860)
Q4295303367-kD elastin-binding protein is a protective "companion" of extracellular insoluble elastin and intracellular tropoelastin
Q37488461A novel cell adhesion region in tropoelastin mediates attachment to integrin αVβ5.
Q73387565Age dependent increase of elastase type protease activity in mouse skin. Effect of UV-irradiation
Q34294303Age-related alterations in the signal transduction pathways of the elastin-laminin receptor
Q33922276Age-related changes in the signaling and function of vascular smooth muscle cells
Q44778500Antagonism of GxxPG fragments ameliorates manifestations of aortic disease in Marfan syndrome mice
Q34621456Antielastin autoimmunity in tobacco smoking-induced emphysema
Q92507571Antiproliferative Effect of Elastin-Derived Peptide VGVAPG on SH-SY5Y Neuroblastoma Cells
Q49029268Assessment of plasma anti-elastin antibodies for use as a diagnostic aid for chronic progressive lymphoedema in Belgian Draught Horses
Q43537055Association of Pulmonary Hypertension with Congenital Portal Hypertension in a Child
Q37332258Attacking the multi-tiered proteolytic pathology of COPD: new insights from basic and translational studies
Q37990551Autoimmunity in chronic obstructive pulmonary disease: clinical and experimental evidence
Q36190792Autoreactive T Cells in Human Smokers is Predictive of Clinical Outcome
Q38943746Bioactive extracellular matrix fragments in lung health and disease
Q40772627Biology of dermal wound repair.
Q31911484Cancer risk related to mammary gland structure and development
Q36201913Cathepsin S cannibalism of cathepsin K as a mechanism to reduce type I collagen degradation
Q24652566Cell adhesion to tropoelastin is mediated via the C-terminal GRKRK motif and integrin alphaVbeta3
Q36630177Cell motility in angiogenesis and tumor metastasis
Q71187105Characteristic interaction of Ca2+ ions with elastin coacervate: ion transport study across coacervate layers of alpha-elastin and elastin model polypeptide, (Val-Pro-Gly-Val-Gly)n
Q33335995Characterization of a putative clone for the 67-kilodalton elastin/laminin receptor suggests that it encodes a cytoplasmic protein rather than a cell surface receptor
Q84978331Characterization of peptide fragments from lung elastin degradation in chronic obstructive pulmonary disease
Q35758976Chemotaxis of metastatic tumor cells: clues to mechanisms from the Dictyostelium paradigm
Q34802380Chronic obstructive pulmonary disease - part 2: pathology and biochemistry of emphysema
Q27333137Circulating Anti-Elastin Antibody Levels and Arterial Disease Characteristics: Associations with Arterial Stiffness and Atherosclerosis
Q68933772Control of cell locomotion: perturbation with an antibody directed against specific glycoproteins
Q38824750Cosmeceuticals: peptides, proteins, and growth factors.
Q53126399Deposition of elafin in the involved vascular wall of neutrophil-mediated cutaneous vasculitis.
Q38983408Effect of an artificial silk elastin-like protein on the migration and collagen production of mouse fibroblasts
Q80528586Effects of elastin-derived peptide on Achilles' tendon healing: an experimental study
Q37355486Elafin, a serine elastase inhibitor, attenuates post-cardiac transplant coronary arteriopathy and reduces myocardial necrosis in rabbits afer heterotopic cardiac transplantation
Q71765023Elastase-induced matrix degradation in arterial organ cultures: an in vitro model of aneurysmal disease
Q52009394Elastic fiber degeneration in Costello syndrome.
Q73515993Elastin degradation products induce adventitial angiogenesis in the Anidjar/Dobrin rat aneurysm model
Q34338306Elastin fragments drive disease progression in a murine model of emphysema
Q28510995Elastin induces myofibrillogenesis via a specific domain, VGVAPG
Q58802865Elastin molecular aging promotes MDA-MB-231 breast cancer cell invasiveness
Q50964282Elastin receptor (S-gal) occupancy by elastin peptides modulates T-cell response during murine emphysema.
Q37118751Elastin sequences trigger transient proinflammatory responses by human dermal fibroblasts
Q38056456Elastin signaling in wound repair
Q57171390Elastin, arterial mechanics, and cardiovascular disease
Q36936068Elastin-Derived Peptides Promote Abdominal Aortic Aneurysm Formation by Modulating M1/M2 Macrophage Polarization.
Q35801306Elastin-based biomaterials and mesenchymal stem cells
Q54318222Elastin-derived peptides increase invasive capacities of lung cancer cells by post-transcriptional regulation of MMP-2 and uPA.
Q73967255Elastin-derived protein coating onto poly(ethylene terephthalate). Technical, microstructural and biological studies
Q36820325Elastin-elastases and inflamm-aging
Q33601688Elastin: molecular description and function
Q52863812Elastins from patients with Williams-Beuren syndrome and healthy individuals differ on the molecular level.
Q37914083Elastomeric polypeptides
Q39580096Entropic elastic processes in protein mechanisms. II. Simple (passive) and coupled (active) development of elastic forces
Q48030996Expression of 67-kDa elastin receptor in annular elastolytic giant cell granuloma: elastin peptides induce monocyte-derived dendritic cells or macrophages to form granuloma in vitro
Q36672445Extracellular matrix remodeling: the common denominator in connective tissue diseases. Possibilities for evaluation and current understanding of the matrix as more than a passive architecture, but a key player in tissue failure
Q28087162Fabricated Elastin
Q92979147Fabrication and In Vitro Characterization of Electrochemically Compacted Collagen/Sulfated Xylorhamnoglycuronan Matrix for Wound Healing Applications
Q36470965Fibrillin-containing microfibrils are key signal relay stations for cell function
Q30963373Fibroblast adhesion to recombinant tropoelastin expressed as a protein A-fusion protein
Q24792418Fibroblast biology. Signals targeting the synovial fibroblast in arthritis.
Q39829706Fibroblast chemotaxis
Q40348725Fibroblast chemotaxis induction by human recombinant interleukin-4. Identification by synthetic peptide analysis of two chemotactic domains residing in amino acid sequences 70-88 and 89-122.
Q49958934Heparan sulfates facilitate harmless amyloidogenic fibril formation interacting with elastin-like peptides
Q52868176Histochemical and immunohistochemical localisation of elastic system fibres in focal reactive overgrowths of oral mucosa.
Q85225427Hypertrophy of the lumbar ligamentum flavum is associated with inflammation-related TGF-β expression
Q36219715Identification of a tumor cell receptor for VGVAPG, an elastin-derived chemotactic peptide
Q67490893Immunolocalization of 67 kDa elastin-binding protein in perinatal rat lungs
Q90656362Impact of Elastin-Derived Peptide VGVAPG on Matrix Metalloprotease-2 and -9 and the Tissue Inhibitor of Metalloproteinase-1, -2, -3 and -4 mRNA Expression in Mouse Cortical Glial Cells In Vitro
Q90236145Impact of elastin-derived VGVAPG peptide on bidirectional interaction between peroxisome proliferator-activated receptor gamma (Pparγ) and beta-galactosidase (β-Gal) expression in mouse cortical astrocytes in vitro
Q34216561Impaired elastin fiber assembly related to reduced 67-kD elastin-binding protein in fetal lamb ductus arteriosus and in cultured aortic smooth muscle cells treated with chondroitin sulfate
Q46531464In vivo vascular engineering of vein grafts: directed migration of smooth muscle cells by perivascular release of elastase limits neointimal proliferation
Q33925296Induction of macrophage chemotaxis by aortic extracts from patients with Marfan syndrome is related to elastin binding protein
Q37112292Interfering with extracellular matrix degradation to blunt inflammation
Q40725072Interstitial cells from the atrial and ventricular sides of the bovine mitral valve respond differently to denuding endocardial injury
Q38337975MMP generated matrikines.
Q59301337Mapping of binding sites for monoclonal antibodies to chick tropoelastin by recombinant DNA techniques
Q30370370Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection.
Q37901244Matrix elastin: a promising biomarker for chronic obstructive pulmonary disease
Q36579878Matrix metalloproteinase 12 accelerates the initiation of atherosclerosis and stimulates the progression of fatty streaks to fibrous plaques in transgenic rabbits.
Q28611041Matrix metalloproteinase degradation of extracellular matrix: biological consequences
Q50184676Matrix metalloproteinases in emphysema.
Q52646214Matrix remodeling in chronic lung diseases.
Q37059601Matrix- and plasma-derived peptides promote tissue-specific injury responses and wound healing in diabetic swine
Q34346648Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation
Q37068538Mechanisms of cigarette smoke-induced COPD: insights from animal models
Q52507754Medial neovascularization in abdominal aortic aneurysms: a histopathologic marker of aneurysmal degeneration with pathophysiologic implications.
Q33815785MicroRNAs differentially expressed in postnatal aortic development downregulate elastin via 3' UTR and coding-sequence binding sites
Q37106864Molecular analysis of amoeboid chemotaxis: Parallel observations in amoeboid phagocytes and metastatic tumor cells
Q39426754Molecular responses of choroidal endothelial cells to elastin derived peptides through the elastin-binding protein (GLB1).
Q37879605Necrotic cell death in atherosclerosis.
Q54285790Neutrophils show chemotaxis to type IV collagen and its 7S domain and contain a 67 kD type IV collagen binding protein with lectin properties.
Q68696356Normal rabbit aqueous humour, fibronectin, and fibroblast conditioned medium are chemoattractant to Tenon's capsule fibroblasts
Q53589920Novel anti-melanogenic hexapeptoids, PAL-10 and PAL-12.
Q43865294Novel properties of peptides derived from the sequence coded by exon 26A of human elastin
Q34787390Oxidative modifications of the C-terminal domain of tropoelastin prevent cell binding
Q48157927PAL-12, a new anti-aging hexa-peptoid, inhibits UVB-induced photoaging in human dermal fibroblasts and 3D reconstructed human full skin model, Keraskin-FT™.
Q37203729Polymers and inflammation: disease mechanisms of the serpinopathies
Q35833724Post-cardiac transplant arteriopathy in piglets is associated with fragmentation of elastin and increased activity of a serine elastase.
Q35750610Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages
Q40372390Proliferative activity of elastin-like-peptides depends on charge and phase transition
Q34706663Putative role of 67 kDa elastin-laminin receptor in tumor invasion
Q77166280Relationship between elastin-derived peptides and the development of microvascular complications: a longitudinal study in children with Type 1 (insulin-dependent) diabetes mellitus
Q35593130Repair of protease-damaged elastin in neonatal rat aortic smooth muscle cell cultures
Q56866496Review
Q72771104Segmental mediolytic arteritis--electronmicroscopic and immunohistochemical study
Q34508831Self-assembling elastin-like peptides growth factor chimeric nanoparticles for the treatment of chronic wounds
Q73201876Solution structure of the amino acid sequence coded by the rarely expressed exon 26A of human elastin: the N-terminal region
Q64109679Specific elastin degradation products are associated with poor outcome in the ECLIPSE COPD cohort
Q46417491Steroid-resistant inflammation in a rat model of chronic obstructive pulmonary disease is associated with a lack of nuclear factor-kappaB pathway activation
Q55008820Structural characterization and in vivo pro-tumor properties of a highly conserved matrikine.
Q30932108Structural characterization of VGVAPG, an elastin-derived peptide
Q47110649Targeted Modulation of Tropoelastin Structure and Assembly
Q41051040Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in mice
Q73846794Tenascin expression is associated with a chronic inflammatory process in abdominal aortic aneurysms
Q26765998The Elastin Receptor Complex: A Unique Matricellular Receptor with High Anti-tumoral Potential
Q74505522The elastin peptides-mediated induction of pro-collagenase-1 production by human fibroblasts involves activation of MEK/ERK pathway via PKA- and PI(3)K-dependent signaling
Q28290469The elastin receptor complex transduces signals through the catalytic activity of its Neu-1 subunit
Q34718276The inflammatory response to cell death
Q34447908The presence of a matrix-derived neutrophil chemoattractant in bronchiolitis obliterans syndrome after lung transplantation.
Q39191612Towards integrating extracellular matrix and immunological pathways.
Q54765547Transient exposure to elastase induces mouse aortic wall smooth muscle cell production of MCP-1 and RANTES during development of experimental aortic aneurysm.
Q37923450Tropoelastin heterogeneity: implications for protein function and disease
Q46726568Tropoelastin interacts with cell-surface glycosaminoglycans via its COOH-terminal domain
Q35666969Uncoupling of Elastin Complex Receptor during In Vitro Aging Is Related to Modifications in Its Intrinsic Sialidase Activity and the Subsequent Lactosylceramide Production
Q44601502Val‐ala‐pro‐gly, an elastin‐derived non‐integrin ligand: Smooth muscle cell adhesion and specificity

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