The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling

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The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M111.244780
P932PMC publication ID3436323
P698PubMed publication ID22807441

P2093author name stringRui Chen
Min Xu
Jiwen Li
Robert D Gerard
Joseph A Garcia
Richard T Hogg
Bertis Little
P2860cites workThe tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysisQ22009936
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensingQ24291102
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylationQ24291783
A conserved family of prolyl-4-hydroxylases that modify HIFQ24291794
FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activityQ24291819
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cellsQ24314526
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alphaQ24338422
Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.Q24534053
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factorQ24536055
Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complexQ24537464
Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alphaQ24554355
Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor proteinQ24599442
Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complexQ24655274
Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathwayQ24672316
Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic responseQ27638869
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylasesQ28118968
Retinal disease in mice lacking hypoxia-inducible transcription factor-2alphaQ28511440
HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent mannerQ28589605
Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse developmentQ28593302
An essential role for p300/CBP in the cellular response to hypoxiaQ28678439
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau proteinQ29615928
Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor proteinQ29615931
Roles of coactivators in hypoxic induction of the erythropoietin geneQ30980340
CREB-binding protein and p300: molecular integrators of hematopoietic transcription.Q33825038
HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietinQ34775400
Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent mannerQ34799862
Differential binding modes of the bromodomains of CREB-binding protein (CBP) and p300 with acetylated MyoDQ36688784
Turn me on: regulating HIF transcriptional activity.Q37059658
Regulation of oxygen homeostasis by hypoxia-inducible factor 1.Q37443475
Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases.Q37683304
Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression.Q39705049
Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1.Q39842472
PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia.Q39968880
Multi-miRNA hairpin method that improves gene knockdown efficiency and provides linked multi-gene knockdownQ40251432
Gene expression profiling of hypoxia signaling in human hepatocellular carcinoma cellsQ40412645
Role of CBP in regulating HIF-1-mediated activation of transcription.Q40477750
Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].Q40527027
Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cellsQ40538152
Functional analysis of hypoxia-inducible factor-1 alpha-mediated transactivation. Identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding proteinQ40716563
Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alphaQ41843388
Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injuryQ47849035
P433issue36
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
P304page(s)30800-30811
P577publication date2012-07-17
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling
P478volume287

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