Thioredoxin reductase inhibition elicits Nrf2-mediated responses in Clara cells: implications for oxidant-induced lung injury

scientific article

Thioredoxin reductase inhibition elicits Nrf2-mediated responses in Clara cells: implications for oxidant-induced lung injury is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1089/ARS.2011.4377
P932PMC publication ID3437047
P698PubMed publication ID22607006
P5875ResearchGate publication ID225046070

P2093author name stringEdward E Schmidt
Lynette K Rogers
Elias S J Arnér
Trent E Tipple
Morgan L Locy
Justin R Prigge
P2860cites workInteractions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cellsQ40340040
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Thioredoxin-related mechanisms in hyperoxic lung injury in miceQ42920997
Linkage analysis of susceptibility to hyperoxia. Nrf2 is a candidate geneQ43829185
Role of NRF2 in protection against hyperoxic lung injury in miceQ43862673
Human placenta thioredoxin reductase: preparation and inhibitor studiesQ43920323
Oxygen-induced pulmonary injury in gamma-glutamyl transpeptidase-deficient miceQ43971589
Absolute gene expression patterns of thioredoxin and glutaredoxin redox systems in mouseQ44572770
Human Protein Atlas of redox systems - what can be learnt?Q46627604
Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinomaQ74034133
Redox atlas of the mouse. Immunohistochemical detection of glutaredoxin-, peroxiredoxin-, and thioredoxin-family proteins in various tissues of the laboratory mouseQ84649121
The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stressQ24648021
Cytoprotective Nrf2 pathway is induced in chronically txnrd 1-deficient hepatocytesQ27346748
Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signalingQ28252897
Thioredoxin and glutaredoxin systemsQ28271236
Glutathione metabolism and its selective modificationQ28289187
Highly active dimeric and low-activity tetrameric forms of selenium-containing rat thioredoxin reductase 1Q28576439
Immunohistochemical localization of thioredoxin and glutaredoxin in mouse embryos and fetusesQ28591730
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathwayQ29547371
Physiological functions of thioredoxin and thioredoxin reductaseQ29615600
ThioredoxinQ29619691
Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in miceQ33646250
Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formationQ33707203
Delayed cardiomyopathy in dystrophin deficient mdx mice relies on intrinsic glutathione resource.Q34086953
Nrf2-mediated transcriptional induction of antioxidant response in mouse embryos exposed to ethanol in vivo: implications for the prevention of fetal alcohol spectrum disordersQ34103158
Maternal docosahexaenoic acid supplementation decreases lung inflammation in hyperoxia-exposed newborn mice.Q34493101
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.Q34604202
Oxygen toxicity and reactive oxygen species: the devil is in the detailsQ34977549
Conditional deletion of Nrf2 in airway epithelium exacerbates acute lung injury and impairs the resolution of inflammationQ35684800
Redox regulation of lung inflammation by thioredoxinQ36009345
The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in miceQ37413347
Focus on mammalian thioredoxin reductases--important selenoproteins with versatile functionsQ37443200
Interferon-gamma regulation of Clara cell gene expression: in vivo and in vitroQ38345330
Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivationQ39636538
Morphologic changes in pulmonary oxygen toxicityQ39733239
Taurine chloramine induces heme oxygenase-1 expression via Nrf2 activation in murine macrophagesQ39751897
Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injuryQ40154556
Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cellsQ40299705
P433issue10
P921main subjectpulmonary injuryQ7259546
P304page(s)1407-1416
P577publication date2012-06-25
P1433published inAntioxidants & Redox SignalingQ4775078
P1476titleThioredoxin reductase inhibition elicits Nrf2-mediated responses in Clara cells: implications for oxidant-induced lung injury
P478volume17

Reverse relations

cites work (P2860)
Q42259921A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification
Q37577458APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase
Q49718783Aurothioglucose Does Not Improve Alveolarization or Elicit Sustained Nrf2 Activation in C57Bl/6 Models of Bronchopulmonary Dysplasia
Q50219625Cross Talk in HEK293 Cells Between Nrf2, HIF, and NF-κB Activities upon Challenges with Redox Therapeutics Characterized with Single-Cell Resolution.
Q90072311Cross-talk between Bcr-abl and the Thioredoxin System in Chronic Myeloid Leukaemia: Implications for CML Treatment
Q47431365Effects of Hyperoxia on the Developing Airway and Pulmonary Vasculature
Q37391555Epigallocatechin-3-gallate enhances key enzymatic activities of hepatic thioredoxin and glutathione systems in selenium-optimal mice but activates hepatic Nrf2 responses in selenium-deficient mice
Q26778366Interplay between cytosolic disulfide reductase systems and the Nrf2/Keap1 pathway
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Q38777415Thioredoxin Reductase Inhibition Attenuates Neonatal Hyperoxic Lung Injury and Enhances Nuclear Factor E2-Related Factor 2 Activation.
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Q28080723TrxR1 as a potent regulator of the Nrf2-Keap1 response system

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