Maternal use of hydroxychloroquine is associated with a reduced risk of recurrent anti-SSA/Ro-antibody-associated cardiac manifestations of neonatal lupus

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Maternal use of hydroxychloroquine is associated with a reduced risk of recurrent anti-SSA/Ro-antibody-associated cardiac manifestations of neonatal lupus is …
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scholarly articleQ13442814

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P356DOI10.1161/CIRCULATIONAHA.111.089268
P932PMC publication ID3437628
P698PubMed publication ID22626746

P50authorJean-Charles PietteQ73305204
Munther A. KhamashtaQ73418907
Jill P BuyonQ80060036
Cecilia PisoniQ100488691
Peter IzmirlyQ42625795
Nathalie Costedoat-ChalumeauQ47262464
P2093author name stringCarolina Llanos
Mimi Y Kim
Amit Saxena
Deborah Friedman
P2860cites workThe rate of recurrence of isolated congenital heart block: a population-based studyQ73565865
Incidence and spectrum of neonatal lupus erythematosus: a prospective study of infants born to mothers with anti-Ro autoantibodiesQ73600793
Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis: a prospective study of 100 womenQ74384559
Neonatal lupus erythematosus: results of maternal corticosteroid therapyQ77853554
Fetal echocardiographic screening of pregnancies of mothers with anti-Ro and/or anti-La antibodiesQ77894676
Antimalarial agents: closing the gate on Toll-like receptors?Q79158393
Outcome of pregnancies in patients with anti-SSA/Ro antibodies: a study of 165 pregnancies, with special focus on electrocardiographic variations in the children and comparison with a control groupQ80845149
Prolongation of the atrioventricular conduction in fetuses exposed to maternal anti-Ro/SSA and anti-La/SSB antibodies did not predict progressive heart block. A prospective observational study on the effects of maternal antibodies on 165 fetusesQ83704882
Effect of hydroxychloroquine on the survival of patients with systemic lupus erythematosus: data from LUMINA, a multiethnic US cohort (LUMINA L)Q31107094
Hydroxychloroquine in lupus pregnancyQ33373145
Protective effect of hydroxychloroquine on renal damage in patients with lupus nephritis: LXV, data from a multiethnic US cohortQ33455990
Cutaneous manifestations of neonatal lupus and risk of subsequent congenital heart blockQ34058776
Clinical predictors of fetal and maternal outcome in systemic lupus erythematosus: a prospective study of 103 pregnanciesQ34131724
Variable selection for propensity score modelsQ34803815
A novel role of endothelin-1 in linking Toll-like receptor 7-mediated inflammation to fibrosis in congenital heart block.Q35182874
Maternal and fetal factors associated with mortality and morbidity in a multi-racial/ethnic registry of anti-SSA/Ro-associated cardiac neonatal lupus.Q35501152
Evaluation of fetuses in a study of intravenous immunoglobulin as preventive therapy for congenital heart block: Results of a multicenter, prospective, open-label clinical trial.Q35546634
Questions about dexamethasone use for the prevention of anti-SSA related congenital heart blockQ35552060
Safety of hydroxychloroquine in pregnant patients with connective tissue diseases. Review of the literatureQ36049718
Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs: a novel pathway to autoimmune-associated heart block.Q36551073
Disease-modifying antirheumatic drugs in pregnancy: current status and implications for the futureQ36592626
Evaluation of the risk of anti-SSA/Ro-SSB/La antibody-associated cardiac manifestations of neonatal lupus in fetuses of mothers with systemic lupus erythematosus exposed to hydroxychloroquineQ36672583
Prospective evaluation of fetuses with autoimmune-associated congenital heart block followed in the PR Interval and Dexamethasone Evaluation (PRIDE) StudyQ37315454
Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic reviewQ37356697
Recurrence rates of cardiac manifestations associated with neonatal lupus and maternal/fetal risk factors.Q37393128
Glucocorticoids in pregnancyQ37845887
Hydroxychloroquine (HCQ) in lupus pregnancy: double-blind and placebo-controlled study.Q41919391
Failure of intravenous immunoglobulin to prevent congenital heart block: Findings of a multicenter, prospective, observational studyQ41936669
Retinal degeneration in 2 children following preventive antimalarial treatment of the mother during pregnancyQ41939291
Ototoxicity of ChloroquineQ41939943
Ineffective therapy, underpowered studies, or merely too little, too late? Risk factors and impact of maternal corticosteroid treatment on outcome in antibody-associated fetal heart blockQ46326060
Isolated atrioventricular block in the fetus: a retrospective, multinational, multicenter study of 175 patientsQ46326249
Autoimmune-associated congenital heart block: demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registryQ46358042
Optimal two-stage designs for phase II clinical trialsQ46412217
Matching using estimated propensity scores: relating theory to practice.Q52891298
Development of heart block in children of SSA/SSB-autoantibody-positive women is associated with maternal age and displays a season-of-birth patternQ57224350
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
hydroxychloroquineQ421094
P304page(s)76-82
P577publication date2012-05-24
P1433published inCirculationQ578091
P1476titleMaternal use of hydroxychloroquine is associated with a reduced risk of recurrent anti-SSA/Ro-antibody-associated cardiac manifestations of neonatal lupus
P478volume126